ASP 7663;ASP-7663;ASP7663
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- CAS号:
- 1190217-35-6
- 英文名:
- ASP7663
- 英文别名:
- ASP7663;ASP7663 >=98% (HPLC);ASP 7663;ASP-7663;ASP7663;(2E)-2-[7-Fluoro-1,2-dihydro-1-(2-methylpropyl)-2-oxo-3H-indol-3-ylidene]acetic acid;Acetic acid, 2-[7-fluoro-1,2-dihydro-1-(2-methylpropyl)-2-oxo-3H-indol-3-ylidene]-, (2E)-;pain,ASP-7663,inhibit,TRP Channel,ASP7663,Transient receptor potential channels,Inhibitor,ASP 7663
- 中文名:
- ASP 7663;ASP-7663;ASP7663
- 中文别名:
- 化合物ASP7663;ASP 7663,TRPA1激活剂
- CBNumber:
- CB03959569
- 分子式:
- C14H14FNO3
- 分子量:
- 263.26
- MOL File:
- 1190217-35-6.mol
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ASP 7663;ASP-7663;ASP7663化学性质
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储存条件:
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Store at -20°C
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溶解度:
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DMSO: 25 mg/ml,Ethanol: 25 mg/ml
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形态:
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A crystalline solid
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ASP 7663;ASP-7663;ASP7663性质、用途与生产工艺
ASP7663 是具有口服活性的、选择性的 TRPA1 激动剂。ASP7663 具有抗便秘和抗腹痛的活性。
ASP7663 concentration dependently increases intracellular Ca
2+
concentration in human, rat, and mouse TRPA1 expressed in HEK293 cells in a similar manner, with respective EC
50
values (95% confidence interval [CI]) of 0.51 (0.40–0.66), 0.54 (0.41–0.72), and 0.50 (0.41–0.63) μmol/L.
ASP7663 concentration-dependently stimulates 5-HT release from QGP-1 cells, a lineage of TRPA1-expressing EC cells, with an EC50 value of 72.5 (52.6–99.9) μmol/L.
ASP7663 significantly improves the loperamide-induced delay in colonic transit in mice.
ASP7663 (orally, 0.3 and 1 mg/kg) significantly shortens the prolonged bead expulsion time caused by loperamide.
ASP7663 (orally, 1 and 3 mg/kg) exhibits inhibitory effects on colorectal distension in rat.
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Animal Model:
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CRD model (colorectal distension in rat).
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Dosage:
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1 and 3 mg/kg.
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Administration:
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Orally.
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Result:
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Significantly reduced the number of abdominal contractions evoked during CRD at pressures of 30, 45, and 60 mmHg. ASP7663 also reduced the number of abdominal contractions by intravenous treatment.
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ASP 7663;ASP-7663;ASP7663
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-101907 | ASP7663 | | 1 mg | 419元 |
| 2024/04/30 | HY-101907 | ASP 7663;ASP-7663;ASP7663
ASP7663 | 1190217-35-6 | 5mg | 1000元 |
ASP 7663;ASP-7663;ASP7663
生产厂家
1190217-35-6, ASP 7663;ASP-7663;ASP7663 相关搜索:
- 合成有机化合物配体
- ASP 7663,TRPA1激活剂
- 化合物ASP7663
- 1190217-35-6
- pain,ASP-7663,inhibit,TRP Channel,ASP7663,Transient receptor potential channels,Inhibitor,ASP 7663
- ASP7663 >=98% (HPLC)
- Acetic acid, 2-[7-fluoro-1,2-dihydro-1-(2-methylpropyl)-2-oxo-3H-indol-3-ylidene]-, (2E)-
- ASP 7663;ASP-7663;ASP7663
- (2E)-2-[7-Fluoro-1,2-dihydro-1-(2-methylpropyl)-2-oxo-3H-indol-3-ylidene]acetic acid
- ASP7663