粘噻唑
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- CAS号:
- 76706-55-3
- 英文名:
- MYXOTHIAZOL
- 英文别名:
- Myxothiazo;MYXOTHIAZOL;5-dimethoxy-4-methyl-;myxothiazolfrommyxobacterium;MYXOTHIAZOL, VIAL WITH 10 MG*;MYXOTHIAZOL FROM MYXOBACTERIUM 95%;MYXOTHIAZOL, FROM MYXOCOCCUS FULVUS;myxothiazol from myxobacterium*myxococcus fulvus;7-(2’-(1,6-dimethyl-2,4-heptadienyl)(2,4’-bithiazol)-4-yl)-6-heptadienamide;2,6-Heptadienamide, 7-(2'-(1,6-dimethyl-2,4-heptadienyl)(2,4'-bithiazol)-4-yl)-3,5-dimethoxy-4-methyl-
- 中文名:
- 粘噻唑
- 中文别名:
- 粘噻唑;黏硫菌素
- CBNumber:
- CB0453976
- 分子式:
- C25H33N3O3S2
- 分子量:
- 487.68
- MOL File:
- 76706-55-3.mol
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粘噻唑化学性质
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沸点:
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679.6±65.0 °C(Predicted)
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密度:
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1.158±0.06 g/cm3(Predicted)
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储存条件:
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-20°C
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溶解度:
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chloroform: soluble9.80 - 10.20mg/mL, clear, colorless to yellow
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酸度系数(pKa):
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14.07±0.50(Predicted)
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粘噻唑性质、用途与生产工艺
Myxothiazol 是一种抗真菌抗生素，是线粒体电子传递链复合体 Ⅲ (complex III or bc1 complex) 抑制剂。Myxothiazol 在0.01~3 μg/ml 浓度范围内可抑制许多酵母菌和真菌的生长。
Myxothiazol inhibits the growth of many yeasts and fungi at concentrations between 0.01 and 3 μg/ml.
Myxothiazol binds to the ubiquinol oxidation site Qo of complex III and blocks electron transfer from ubiquinol to cytochrome b and thus inhibits complex III activity.
Myxothiazol (i.p.; 0.56 mg/kg; daily for 4 days)-induced complex III inhibition can be induced in mice for four days in a row without overt hepatotoxicity or lethality.
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Animal Model:
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C57Bl/J6 mice
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Dosage:
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0.56 mg/kg
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Administration:
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I.p.; 24 hours intervals for at most 4 times
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Result:
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A reversible complex III activity decrease to 50% of control value occurred at 2 h post-injection. At 74 h only minor histological changes in the liver were found, supercomplex formation was preserved and no significant changes in the expression of genes indicating hepatotoxicity or inflammation were found.
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粘噻唑
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/04/30 | HY-112177 | 粘噻唑
Myxothiazol | 76706-55-3 | 1 mg | 4200元 |
| 2023/03/20 | HY-112177 | 粘噻唑
Myxothiazol | 76706-55-3 | 5 mg | 10500元 |
粘噻唑
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76706-55-3, 粘噻唑 相关搜索:
- Spectrum of Activity
- Peptides
- Mechanism of Action
- Chemical Structure Class
- Cell Stress
- AntifungalAntibiotics
- Antibiotics G-MAntibiotics
- Antibiotics A to
- Antibiotics
- Mitochondrial InhibitorsAntibiotics
- Inhibits an EnzymeNitric Oxide and Cell Stress
- BioChemical
- Antibiotics A to Z
- Antibiotics
- Antibiotics G-M
- C25H33N3O3S2
- 黏硫菌素
- 粘噻唑
- 76706-55-3
- 2,6-Heptadienamide, 7-[2'-[(1S,2E,4E)-1,6-dimethyl-2,4-heptadien-1-yl][2,4'-bithiazol]-4-yl]-3,5-dimethoxy-4-methyl-, (2E,4R,5S,6E)-
- Myxothiazo
- 2,6-Heptadienamide, 7-(2'-(1,6-dimethyl-2,4-heptadienyl)(2,4'-bithiazol)-4-yl)-3,5-dimethoxy-4-methyl-
- 2,6-Heptadienamide, 7-(2'-((1S,2E,4E)-1,6-dimethyl-2,4-heptadienyl)(2,4'-bithiazol)-4-yl)-3,5-dimethoxy-4-methyl-, (2E,4R,5S,6E)-
- myxothiazolfrommyxobacterium
- MYXOTHIAZOL FROM MYXOBACTERIUM 95%
- MYXOTHIAZOL, VIAL WITH 10 MG*
- myxothiazol from myxobacterium*myxococcus fulvus
- 7-(2’-(1,6-dimethyl-2,4-heptadienyl)(2,4’-bithiazol)-4-yl)-6-heptadienamide
- 5-dimethoxy-4-methyl-
- MYXOTHIAZOL
- MYXOTHIAZOL, FROM MYXOCOCCUS FULVUS