3-DEAZAADENOSINE HYDROCHLORIDE
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- CAS号:
- 86583-19-9
- 英文名:
- 3-Deazaadenosine (hydrochloride)
- 英文别名:
- 3-Deaza-rA?HCl;3-Deazaadenosine (hydrochloride);1H-Imidazo[4,5-c]pyridin-4-amine,1-β-Dribofuranosyl-,monohydrochloride;HIV,3-Deazaadenosine,Human immunodeficiency virus,Inhibitor,3 Deazaadenosine hydrochloride,3Deazaadenosine hydrochloride,inhibit
- 中文名:
- 3-DEAZAADENOSINE HYDROCHLORIDE
- 中文别名:
- 3-脱氮腺苷盐酸盐;化合物3-DEAZAADENOSINE HYDROCHLORIDE
- CBNumber:
- CB04797014
- 分子式:
- C11H15ClN4O4
- 分子量:
- 302.72
- MOL File:
- 86583-19-9.mol
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3-DEAZAADENOSINE HYDROCHLORIDE化学性质
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储存条件:
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Store at -20°C
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溶解度:
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DMSO: 30 mg/ml; PBS (pH 7.2): 10 mg/ml
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形态:
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A crystalline solid
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3-DEAZAADENOSINE HYDROCHLORIDE性质、用途与生产工艺
3-Deazaadenosine HCl (3-DZA, c3Ado)是一种有效的 S-adenosylhomocysteine hydrolase 的抑制剂,Ki值为3.9 μM。3-Deazaadenosine HCl 可抑制细菌脂多糖诱导的 TNF-α 和 IL-1β 的转录。3-Deazaadenosine HCl 可抑制 NF-κB 的转录活性,阻止FCS诱导的 Ras 的羧基甲基化,并降低FCS诱导的 ERK1/2 和 Akt 磷酸化。3-Deazaadenosine HCl 具有抗炎、抗增殖和抗HIV的活性。
Target | Value |
S-adenosylhomocysteine hydrolase
(Cell-free assay)
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3.9 μM(Ki)
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3-Deazaadenosine is an inhibitor of S-adenosylhomocysteine hydrolase, with a K
i
of 3.9 µM. 3-Deazaadenosine shows anti-HIV effect, and inhibits p24 antigen in peripheral blood mononuclear (PBMCs) cells infected with HIV-1 isolates (A012 and A018) with IC
50
s of 0.15 and 0.20 µM, respectively. 3-Deazaadenosine (1-100 µM) inhibits LPS-induced expression of TNF-α mRNA, increases DNA binding activity of NF-κB, and causes proteolytic degradation of IκBα, but Not IκBβ in RAW 264.7 cells. 3-Deazaadenosine (100 µM) enhances nuclear translocation of NF-κB, but blocks LPS-induced NF-κB transcriptional activity, and such inhibition is augmented by the addition of homocysteine. 3-Deazaadenosine (50, 100 µM) dose-dependently inhibits the phosphorylation of Raf and ERK, protein-dependent kinase 1, protein kinase B (Akt), and forkhead transcription factor FoxO1a. 3-Deazaadenosine (50 µM) suppresses vascular smooth muscle cell (VSMC) proliferation via interfering with Ras signaling.
3-DEAZAADENOSINE HYDROCHLORIDE
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/04/30 | HY-W013332A | 3-DEAZAADENOSINE HYDROCHLORIDE 3-Deazaadenosine hydrochloride | 86583-19-9 | 1mg | 1713元 |
2024/04/30 | HY-W013332A | 3-DEAZAADENOSINE HYDROCHLORIDE 3-Deazaadenosine hydrochloride | 86583-19-9 | 10mM * 1mLin DMSO | 2597元 |
3-DEAZAADENOSINE HYDROCHLORIDE
生产厂家
86583-19-9, 3-DEAZAADENOSINE HYDROCHLORIDE 相关搜索:
- 药靶配体
- 化合物3-DEAZAADENOSINE HYDROCHLORIDE
- 3-脱氮腺苷盐酸盐
- 86583-19-9
- 1H-Imidazo[4,5-c]pyridin-4-amine,1-β-Dribofuranosyl-,monohydrochloride
- HIV,3-Deazaadenosine,Human immunodeficiency virus,Inhibitor,3 Deazaadenosine hydrochloride,3Deazaadenosine hydrochloride,inhibit
- 3-Deaza-rA?HCl
- 3-Deazaadenosine (hydrochloride)