CDK5 INHIBITOR 20-223
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- CAS号:
- 865317-30-2
- 英文名:
- CDK5 inhibitor 20-223
(CP 668863)
- 英文别名:
- CDK5 inhibitor 20-223;CDK5 inhibitor 20-223
(CP 668863);2-Naphthaleneacetamide, N-(5-cyclobutyl-1H-pyrazol-3-yl)-;CDK5 inhibitor 20223,CDK5 inhibitor 20 223,CDK-5 inhibitor 20-223
- 中文名:
- CDK5 INHIBITOR 20-223
- 中文别名:
- CBNumber:
- CB04844633
- 分子式:
- C19H19N3O
- 分子量:
- 305.37
- MOL File:
- 865317-30-2.mol
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CDK5 INHIBITOR 20-223化学性质
CDK5 INHIBITOR 20-223性质、用途与生产工艺
CDK5 inhibitor 20-223 是一种有效的 CDK2 和 CDK5 抑制剂，IC50 分别为 6.0 和 8.8 nM。CDK5 inhibitor 20-223 有潜力用于结肠直肠癌 (CRC) 的研究。
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CDK2
6.0 nM (IC
50
)
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CDK5
8.8 nM (IC
50
)
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CDK5 inhibitor 20-223 (10 nM-10 μM; 72 hours) potently inhibits cell growth in a panel of colorectal cancer (CRC) cell lines.
CDK5 inhibitor 20-223 (0.3125-20 μM; 6 hours) induces a dose-dependent decrease in pRB (S807/811) and pFAK (S732) levels in each of the three CRC cell lines.
Cell Viability Assay
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Cell Line:
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CRC cell lines SW620, DLD1, HT29, HCT116, FET, CBS, and GEO cells
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Concentration:
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10 μM, 1 μM, 100 nM, 10 nM
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Incubation Time:
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72 hours
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Result:
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Reduced cell growth. IC50s of 168±20, 480±41, 360±72, 763±92, 117±49, 568±49, 79±31 nM for SW620, DLD1, HT29, HCT116, FET, CBS, and GEO cells.
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Western Blot Analysis
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Cell Line:
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CRC cell lines GEO, HCT116 and HT29
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Concentration:
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20, 10, 5, 2.5, 1.25, 0.625, 0.3125 μM
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Incubation Time:
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6 hours
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Result:
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Did not affect the total levels of CDK2/5, and the levels of total FAK or total Retinoblastoma protein (Rb).
Induced a dose-dependent decrease in pRB (S807/811) and pFAK (S732) levels.
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CDK5 inhibitor 20-223 (8mg/kg; subcutaneously; for 14 injections) shows anti-tumor activity in human CRC xenograft tumors in nude mice.
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Animal Model:
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Athymic nude mice
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Dosage:
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8 mg/kg
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Administration:
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Injections were given subcutaneously daily for the first week and every other day for two more weeks for a total of 14 injections.
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Result:
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Reduced tumor growth and tumor weight in vivo.
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CDK5 INHIBITOR 20-223
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-123772 | CDK5 inhibitor 20-223 | | 1 mg | 909元 |
| 2024/04/30 | HY-123772 | CDK5 INHIBITOR 20-223
CDK5 inhibitor 20-223 | 865317-30-2 | 5mg | 2000元 |
CDK5 INHIBITOR 20-223
生产厂家
865317-30-2, CDK5 INHIBITOR 20-223 相关搜索:
- 制剂-抑制剂
- 865317-30-2
- CDK5 inhibitor 20223,CDK5 inhibitor 20 223,CDK-5 inhibitor 20-223
- CDK5 inhibitor 20-223
(CP 668863)
- CDK5 inhibitor 20-223
- 2-Naphthaleneacetamide, N-(5-cyclobutyl-1H-pyrazol-3-yl)-