手霉素A
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- CAS号:
- 52665-74-4
- 英文名:
- MANUMYCIN A
- 英文别名:
- UCF 1C;manumycin;NSC 622141;MANUMYCIN A;Chiromycin A;MANUMYCIN A, STREPTOMYCES PARVULUS;manumycin A from streptomyces parvulus;Manumycin A, Streptomyces parvulus - CAS 52665-74-4 - Calbiochem;N-[5-Hydroxy-5-[7-[(2-hydroxy-5-oxo-1-cyclopenten-1-yl)amino]-7-oxohepta-1,3,5-trienyl]-2-oxo-7-oxabicyclo[4.1.0]hept-3-en-3-yl]-2,4,6-trimethyldeca-2,4-dienamide;(2E,4E)-N-[(5R)-5-hydroxy-5-[(1E,3E,5E)-7-[(2-hydroxy-5-oxocyclopenten-1-yl)amino]-7-oxohepta-1,3,5-trienyl]-2-oxo-7-oxabicyclo[4.1.0]hept-3-en-3-yl]-2,4,6-trimethyldeca-2,4-dienamide
- 中文名:
- 手霉素A
- 中文别名:
- 手霉素;手霉素A;MANUMYCIN A(手霉素A)
- CBNumber:
- CB1103133
- 分子式:
- C31H38N2O7
- 分子量:
- 550.64
- MOL File:
- 52665-74-4.mol
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手霉素A化学性质
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沸点:
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863.6±65.0 °C(Predicted)
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密度:
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1.26±0.1 g/cm3(Predicted)
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储存条件:
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2-8°C
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溶解度:
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Soluble in DMSO (up to 10 mg/ml), in Ethanol (up to 5 mg/ml) or in DMF (up to 20 mg/ml)
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酸度系数(pKa):
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3.80±0.30(Predicted)
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形态:
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Yellow to brown solid
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颜色:
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Yellow
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稳定性:
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Stable for 1 year from date of purchase as supplied. Solutions in DMSO, ethanol, or DMF may be stored at -20°C for up to 3 months.
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手霉素A性质、用途与生产工艺
Manumycin A 是一种抗生素。Manumycin A 作为一种选择性、竞争性的 farnesyltransferase (FTase) 抑制剂，与 farnesylpyrophosphate (Ki =1.2 μM) 有关，并且作为 Ras 蛋白质的非竞争性抑制剂。Manumycin A 诱导细胞凋亡并发挥抗肿瘤活性。Manumycin A 通过靶向抑制 Ras/Raf/ERK1/2 信号转导，抑制外泌体生物发生 (exosome biogenesis) 及分泌。Manumycin A 也是 nSMase 抑制剂 (EC50=0.25 μM)。
Farnesyltransferase, Ras, nSMase inhibitor
手霉素A
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-N6796 | 手霉素A
Manumycin A | 52665-74-4 | 1mg | 3200元 |
| 2023/03/20 | HY-N6796 | 手霉素A
Manumycin A | 52665-74-4 | 5mg | 10500元 |
手霉素A
生产厂家
全球有 91家供应商
手霉素A国内生产厂家
52665-74-4, 手霉素A 相关搜索:
- Post-translational Modification
- G Protein Function
- Enzyme Inhibitors by Enzyme
- D to
- Farnesyl transferase, RasG Proteins and Cyclic Nucleotides
- 抑制剂
- 医药原料
- G Protein Function
- G Proteins and Cyclic Nucleotides
- Post-translational Modification
- BioChemical
- Cell Biology
- Cell Signaling and Neuroscience
- MANUMYCIN A(手霉素A)
- 手霉素A
- 手霉素
- 52665-74-4
- Chiromycin A
- 2,4-Decadienamide, N-[(1S,5S,6R)-5-hydroxy-5-[(1E,3E,5E)-7-[(2-hydroxy-5-oxo-1-cyclopenten-1-yl)amino]-7-oxo-1,3,5-heptatrien-1-yl]-2-oxo-7-oxabicyclo[4.1.0]hept-3-en-3-yl]-2,4,6-trimethyl-, (2E,4E,6R)-
- Manumycin A, Streptomyces parvulus - CAS 52665-74-4 - Calbiochem
- (2E,4E)-N-[(5R)-5-hydroxy-5-[(1E,3E,5E)-7-[(2-hydroxy-5-oxocyclopenten-1-yl)amino]-7-oxohepta-1,3,5-trienyl]-2-oxo-7-oxabicyclo[4.1.0]hept-3-en-3-yl]-2,4,6-trimethyldeca-2,4-dienamide
- UCF 1C
- NSC 622141
- manumycin A from streptomyces parvulus
- manumycin
- N-[5-Hydroxy-5-[7-[(2-hydroxy-5-oxo-1-cyclopenten-1-yl)amino]-7-oxohepta-1,3,5-trienyl]-2-oxo-7-oxabicyclo[4.1.0]hept-3-en-3-yl]-2,4,6-trimethyldeca-2,4-dienamide
- MANUMYCIN A, STREPTOMYCES PARVULUS
- MANUMYCIN A