左西孟旦杂质
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- CAS号:
- 220246-81-1
- 英文名:
- (R)-N-Acetyl-6-(4-aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone
- 英文别名:
- OR-1896;OR 1896,OR1896;13C,2H3]-Levosimendan metabolite;(R)-N-Acetyl-6-(4-aminophenyl)-4,5-dihydro-5-methyl-3(2H)-p;(R)-N-Acetyl-6-(4-aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone;(R)-N-(4-(4-Methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)phenyl)acetamide;(R)-N-[4-(1,4,5,6-Tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]-acetamide;Acetamide, N-[4-[(4R)-1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl]phenyl]-
- 中文名:
- 左西孟旦杂质
- 中文别名:
- 化合物 T12315;13C,2H3]-左西孟旦代谢物;(R)-N-乙酰基-6-(4-氨基苯基)-4,5-二氢-5-甲基-3(2H)-哒嗪酮
- CBNumber:
- CB11120951
- 分子式:
- C13H15N3O2
- 分子量:
- 245.28
- MOL File:
- 220246-81-1.mol
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左西孟旦杂质化学性质
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熔点:
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224-226°C
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密度:
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1.27±0.1 g/cm3(Predicted)
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储存条件:
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-20°C Freezer
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溶解度:
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Acetone (Slightly), DMSO (Slightly), Methanol (Slightly)
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形态:
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Solid
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酸度系数(pKa):
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13.67±0.60(Predicted)
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颜色:
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Pale Yellow to Light Yellow
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CAS 数据库:
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220246-81-1
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左西孟旦杂质性质、用途与生产工艺
OR-1896 是 Levosimendan 的活性长寿代谢产物。OR-1896 是一种高选择性磷酸二酯酶 (PDE III) 抑制剂，是一种功能强大的血管扩张剂。OR-1896 可以打开 ATP 敏感的 K+ 通道，并具有 Ca2+ 致敏作用。OR-1896 可减轻心肌细胞的凋亡，心脏重塑和心肌炎症。
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PDE3/PDE Ⅲ
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K+ Channel
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Drug Metabolite
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There are many evidences has accumulated and revealed a variety of beneficial pleiotropic effects OR-1896. OR-1896 evokes prominent vasodilatory responses, activation of ATP-sensitive sarcolemmal K
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channels of smooth muscle cells appears as a powerful vasodilator mechanism. Additionally, activation of ATP-sensitive K
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channels in the mitochondria potentially extends the range of cellular actions towards the modulation of mitochondrial ATP production and implicates a pharmacological mechanism for cardioprotection.
During the metabolism of Levosimendan approximately 5% of the drug is converted to the metabolite OR-1855 in the large intestine, and then acetylated in the liver to form the active metabolite OR-1896. Binding to plasma proteins is 98% for Levosimendan but only 40% for OR-1896. Unlike Levosimendan, which has an elimination half-life of 1-1.5 h, the half-life of OR-1896 is about 75 to 80 h allowing cardiovascular effects to persist up to 7 to 9 days after discontinuation of a 24-hour infusion of levosimendan. The pharmacokinetic of the parent drug is unaltered in subjects with severe renal impairment or with moderate hepatic impairment, whereas the elimination of its metabolites (OR-1896) can be prolonged.
左西孟旦杂质
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| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-135746 | 左西孟旦杂质
OR-1896 | 220246-81-1 | 10mg | 5000元 |
| 2024/01/25 | HY-135746 | 左西孟旦杂质
OR-1896 | 220246-81-1 | 5mg | 2800元 |
220246-81-1, 左西孟旦杂质 相关搜索:
- Heterocycles
- Aromatics
- Pharmaceuticals
- Metabolites & Impurities
- Intermediates & Fine Chemicals
- (R)-N-乙酰基-6-(4-氨基苯基)-4,5-二氢-5-甲基-3(2H)-哒嗪酮
- 13C,2H3]-左西孟旦代谢物
- 化合物 T12315
- 220246-81-1
- (R)-N-Acetyl-6-(4-aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone
- OR 1896,OR1896
- 13C,2H3]-Levosimendan metabolite
- (R)-N-Acetyl-6-(4-aminophenyl)-4,5-dihydro-5-methyl-3(2H)-p
- Acetamide, N-[4-[(4R)-1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl]phenyl]-
- (R)-N-(4-(4-Methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)phenyl)acetamide
- OR-1896
- (R)-N-[4-(1,4,5,6-Tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]-acetamide