PHOSPHORAMIDEMUSTARD
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- CAS号:
- 1566-15-0
- 英文名:
- PHOSPHORAMIDEMUSTARD
- 英文别名:
- Ai3-51834;Phosphamide Mustard;Phosphamide Mustard Cyclohexamine Salt;Phosphoramide mustard (cyclohexanamine);Phosphoramide mustard cyclohexylammonium salt;amino-[bis(2-chloroethyl)amino]phosphinic acid,cyclohexanamine;N,N-Bis(2-chloroethyl)phosphorodiaMidic Acid CyclohexylaMine Salt;Phosphorodiamidic acid, N,N-bis(2-chloroethyl)-, compound with cyclohexanamine (1:1);Phosphorodiamidic acid, N,N-bis(2-chloroethyl)-, compd. with cyclohexanamine(1:1) (9ci)
- 中文名:
- PHOSPHORAMIDEMUSTARD
- 中文别名:
- 磷酰胺氮芥环己盐;N,N-双(2-氯乙基)磷二酰胺酸环己胺盐;PHOSPHAMIDE MUSTARD CYCLOHEXAMINE SALT;N,N-BIS(2-CHLOROETHYL)PHOSPHORODIAMIDIC ACID COMPOUND WITH CYCLOHEXANAMINE (1:1)
- CBNumber:
- CB11447771
- 分子式:
- C10H24Cl2N3O2P
- 分子量:
- 320.196221
- MOL File:
- 1566-15-0.mol
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PHOSPHORAMIDEMUSTARD化学性质
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熔点:
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100-103°C
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储存条件:
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Hygroscopic, -20°C Freezer, Under inert atmosphere
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溶解度:
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Chloroform (Slightly), Methanol (Slightly)
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形态:
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Solid
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颜色:
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White to Off-White
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稳定性:
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Moisture Sensitive
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PHOSPHORAMIDEMUSTARD性质、用途与生产工艺
Phosphoramide mustard cyclohexanamine 是环磷酰胺 (HY-17420) 的活性代谢物，具有抗肿瘤活性。Phosphoramide mustard cyclohexanamine 能诱导 DNA 损伤
Phosphoramide mustard cyclohexanamine causes cytotoxicity through forming cross-linked DNA adducts which inhibit DNA strand separation during replication.
Phosphoramide mustard cyclohexanamine (3-6 μM; 48 hours) reduces cell viability in rat spontaneously immortalized granulosa cells (SIGCs).
Phosphoramide mustard cyclohexanamine (3-6 μM; 24-48 hours) induces DNA adduct formation and ovarian DNA damage.
Phosphoramide mustard cyclohexanamine (3-6 μM; 24-48 hours) increases DNA damage responses (DDR) gene mRNA expression levels and DDR proteins.
Cell Viability Assay
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Cell Line:
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SIGCs
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Concentration:
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0.5 μM, 1 μM, 3 μM, 6 μM
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Incubation Time:
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48 hours
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Result:
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Reduced cell viability at concentrations of 3 μM and higher.
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RT-PCR
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Cell Line:
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SIGCs
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Concentration:
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3 μM, 6 μM
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Incubation Time:
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24 hours, 48 hours
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Result:
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Increased DDR gene mRNA expression levels.
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Western Blot Analysis
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Cell Line:
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SIGCs
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Concentration:
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3 μM, 6 μM
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Incubation Time:
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24 hours, 48 hours
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Result:
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Generally increased DDR proteins.
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Phosphoramide mustard cyclohexanamine (2.1-20.7 mg/kg; i.p.; daily; for 5 days) inhibits subcutaneous tumor growth in rats.
Phosphoramide mustard cyclohexanamine exhibits terminal elimination half-lives (rat 15.1 min) following intravenous administration (rat 59.4 mg/kg).
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Animal Model:
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Rat, subcutaneously implanted Walker 256 carcinosarcoma tumor
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Dosage:
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2.1 mg/kg, 4.8 mg/kg, 10.4 mg/kg, 20.7 mg/kg
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Administration:
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Intraperitoneal injection, once daily, for 5 consecutive days
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Result:
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Required to produce 50% inhibition of subcutaneous tumor growth with dose of 12 mg/kg.
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Animal Model:
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Rats
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Dosage:
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86.0 mg/kg (Pharmacokinetic Analysis)
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Administration:
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Intravenous injection
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Result:
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T
1/2
(15.1 min).
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PHOSPHORAMIDEMUSTARD
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/04/30 | HY-137316A | Phosphoramide mustard cyclohexanamine | | 1 mg | 1545元 |
| 2024/04/30 | HY-137316A | PHOSPHORAMIDEMUSTARD
Phosphoramide mustard (cyclohexanamine) | 1566-15-0 | 10mg | 6000元 |
PHOSPHORAMIDEMUSTARD
生产厂家
1566-15-0, PHOSPHORAMIDEMUSTARD 相关搜索:
- Amino Acids & Derivatives, Heterocycles, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
- N,N-BIS(2-CHLOROETHYL)PHOSPHORODIAMIDIC ACID COMPOUND WITH CYCLOHEXANAMINE (1:1)
- N,N-双(2-氯乙基)磷二酰胺酸环己胺盐
- 磷酰胺氮芥环己盐
- PHOSPHAMIDE MUSTARD CYCLOHEXAMINE SALT
- 1566-15-0
- Phosphoramide mustard (cyclohexanamine)
- Phosphoramide mustard cyclohexylammonium salt
- Phosphamide Mustard Cyclohexamine Salt
- Phosphamide Mustard
- amino-[bis(2-chloroethyl)amino]phosphinic acid,cyclohexanamine
- N,N-Bis(2-chloroethyl)phosphorodiaMidic Acid CyclohexylaMine Salt
- Phosphorodiamidic acid, N,N-bis(2-chloroethyl)-, compound with cyclohexanamine (1:1)
- Phosphorodiamidic acid, N,N-bis(2-chloroethyl)-, compd. with cyclohexanamine(1:1) (9ci)
- Ai3-51834