2,4-二氯-N-(异丙基)-N-[2-[(异丙基)氨基]乙基]苯磺酰胺
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- CAS号:
- 946387-07-1
- 英文名:
- 2,4-dichloro-N-isopropyl-N-[2-(isopropylamino)ethyl]benzenesulfonamide
- 英文别名:
- PM-0016;RN 1734;TRPV4 Antagonist I, RN-1734;TRPV4 Antagonist I, RN-1734 - CAS 946387-07-1 - Calbiochem;2,4-dichloro-N-isopropyl-N-[2-(isopropylamino)ethyl]benzenesulfonamide;2,4-dichloro-N-propan-2-yl-N-[2-(propan-2-ylamino)ethyl]benzenesulfonamide;RN-1734 (2,4-Dichloro-N-isopropyl-N-(2-isopropylaminoethyl)benzenesulfonamide);2,4-Dichloro-N-isopropyl-N-(2-isopropylaminoethyl)benzenesulphonamide (RN-1734);2,4-Dichloro-N-(1-methylethyl)-N-[2-[(1-methylethyl)amino]ethyl]benzenesulfonamide;Benzenesulfonamide, 2,4-dichloro-N-(1-methylethyl)-N-[2-[(1-methylethyl)amino]ethyl]-
- 中文名:
- 2,4-二氯-N-(异丙基)-N-[2-[(异丙基)氨基]乙基]苯磺酰胺
- 中文别名:
- 化合物RN-1734;RN-1734,TRPV4拮抗剂;2,4-二氯-N-(异丙基)-N-[2-[(异丙基)氨基]乙基]苯磺酰胺;TRPV4 ANTAGONIST I, RN-1734 CALBIOCHEM;2,4-二氯-N-(1-甲基乙基)-N-[2-[(1-甲基乙基)氨基]乙基]苯磺酰胺
- CBNumber:
- CB11529521
- 分子式:
- C14H22Cl2N2O2S
- 分子量:
- 353.31
- MOL File:
- 946387-07-1.mol
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2,4-二氯-N-(异丙基)-N-[2-[(异丙基)氨基]乙基]苯磺酰胺化学性质
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储存条件:
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2-8°C
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溶解度:
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DMSO: >20mg/mL
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形态:
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Yellow solid
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颜色:
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white to off-white
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2,4-二氯-N-(异丙基)-N-[2-[(异丙基)氨基]乙基]苯磺酰胺性质、用途与生产工艺
RN-1734 (TRPV4 Antagonist I)是一种选择性的 transient receptor potential vanilloid 4 (TRPV4) 拮抗剂，对于hTRPV4、mTRPV4和rTRPV4的IC50值分别为2.3 μM、5.9 μM和3.2 μM。RN-1734 在不改变olig2阳性细胞数量的情况下，可减轻脱髓鞘作用并抑制神经胶质活化以及抑制 tumor necrosis factor α (TNF-α) 和 interleukin 1β (IL-1β) 的产生。
| Target | Value |
TNF-α
()
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IL-1β
()
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hTRPV4
(Cell-free assay)
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2.3 μM
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rTRPV4
(Cell-free assay)
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3.2 μM
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mTRPV4
(Cell-free assay)
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5.9 μM
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RN-1734 (27 hours; 10μM) reverses the increase in the apoptotic rate of oligodendrocytes induced by CM (LPS-activated microglia group) apoptosis.
RN-1734 (27 hours; 10μM) alleviates CM-induced decreases in CNP.
Apoptosis Analysis
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Cell Line:
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Microglial cells
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Concentration:
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27 hours
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Incubation Time:
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10μM
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Result:
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Significantly decreased the percentage of cleaved-caspase 3 positive cells.
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Western Blot Analysis
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Cell Line:
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Microglial cells
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Concentration:
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27 hours
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Incubation Time:
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10 μM
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Result:
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Alleviated CM (with LPS only)-induced decreases in CNP.
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RN-1734 (0.5 μl; microinjector pump; daily for 5 weeks) significantly reverses the decrease in CNP protein and improves myelination in CPZ-induced demyelination mouse.
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Animal Model:
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CPZ-induced demyelination mouse model (C57BL/6 male mice)
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Dosage:
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0.5 μl (10 μM in 5% DMSO and 0.9% NaCl)
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Administration:
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Microinjector pump for 5 weeks
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Result:
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Significantly reversed the decrease in CNP protein and improved myelination in CPZ-induced demyelination mouse.
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2,4-二氯-N-(异丙基)-N-[2-[(异丙基)氨基]乙基]苯磺酰胺
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-19975 | RN-1734 | | 1 mg | 220元 |
| 2024/04/30 | HY-19975 | 2,4-二氯-N-(异丙基)-N-[2-[(异丙基)氨基]乙基]苯磺酰胺
RN-1734 | 946387-07-1 | 5mg | 550元 |
2,4-二氯-N-(异丙基)-N-[2-[(异丙基)氨基]乙基]苯磺酰胺
生产厂家
946387-07-1, 2,4-二氯-N-(异丙基)-N-[2-[(异丙基)氨基]乙基]苯磺酰胺 相关搜索:
- 合成有机化合物配体
- RN-1734,TRPV4拮抗剂
- TRPV4 ANTAGONIST I, RN-1734 CALBIOCHEM
- 2,4-二氯-N-(1-甲基乙基)-N-[2-[(1-甲基乙基)氨基]乙基]苯磺酰胺
- 化合物RN-1734
- 2,4-二氯-N-(异丙基)-N-[2-[(异丙基)氨基]乙基]苯磺酰胺
- 946387-07-1
- RN1734,Inhibitor,RN-1734,Transient receptor potential channels,TRP Channel,inhibit,RN 1734
- PM-0016
- RN-1734 (2,4-Dichloro-N-isopropyl-N-(2-isopropylaminoethyl)benzenesulfonamide)
- Benzenesulfonamide, 2,4-dichloro-N-(1-methylethyl)-N-[2-[(1-methylethyl)amino]ethyl]-
- 2,4-dichloro-N-propan-2-yl-N-[2-(propan-2-ylamino)ethyl]benzenesulfonamide
- TRPV4 Antagonist I, RN-1734 - CAS 946387-07-1 - Calbiochem
- TRPV4 Antagonist I, RN-1734
- 2,4-Dichloro-N-(1-methylethyl)-N-[2-[(1-methylethyl)amino]ethyl]benzenesulfonamide
- 2,4-Dichloro-N-isopropyl-N-(2-isopropylaminoethyl)benzenesulphonamide (RN-1734)
- RN 1734
- 2,4-dichloro-N-isopropyl-N-[2-(isopropylamino)ethyl]benzenesulfonamide