喹夫拉朋钠
|
|
|
- CAS号:
- 147030-01-1
- 英文名:
- sodium 3-[1-[(4-chlorophenyl)methyl]-5-(quinolin-2-ylmethoxy)-3-tert-butylsulfanyl-indol-2-yl]-2,2-dimethyl-propanoate
- 英文别名:
- MK 591;MK-591 sodium;Quiflapon SodiuM;QUIFLAPON SODIUM (MK591);QUIFLAPON SODIUM; MK-591; MK 591;sodium 3-[1-[(4-chlorophenyl)methyl]-5-(quinolin-2-ylmethoxy)-3-tert-butylsulfanyl-indol-2-yl]-2,2-dimethyl-propanoate;1-[(4-Chlorophenyl)Methyl]-3-[(1,1-diMethylethyl)thio]-α,α-diMethyl-5-(2-quinolinylMethoxy)-1H-Indole-2-propanoic Acid SodiuM Salt
- 中文名:
- 喹夫拉朋钠
- 中文别名:
- 喹夫拉朋钠
- CBNumber:
- CB11568667
- 分子式:
- C34H34ClN2NaO3S
- 分子量:
- 0
- MOL File:
- 147030-01-1.mol
|
|
|
喹夫拉朋钠化学性质
-
溶解度:
-
DMSO : 50 mg/mL (82.08 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
-
|
-
形态:
-
Powder
-
|
喹夫拉朋钠性质、用途与生产工艺
Quiflapon sodium (MK-591 sodium) 是选择性的，特异性的 FLAP 抑制剂。Quiflapon sodium 是一种有效的，具有口服活性的白三烯生物合成 (leukotriene biosynthesis) 抑制剂。诱导细胞凋亡 (apoptosis)。
Quiflapon sodium (MK591) and SB203580 are able to block SEB-induced human PBMC cell proliferation. Quiflapon sodium (MK591) down regulates three genes [for cathepsin L, IL-17 and guanylate binding protein (GBP)-2] that are up regulated by SEB. Quiflapon sodium (MK591) undergoes apoptosis within hours of treatment. Quiflapon sodium also induces rapid activation of the stress kinase, c-Jun N-terminal kinase (JNK), which plays an important role in the apoptosis process. Quiflapon sodium triggers apoptosis in prostate cancer cells without inhibition of PI3K-Akt, or ERK. Moreover, Quiflapon sodium and LY294002 exert synergistic effect in inducing apoptosis in prostate cancer cells. Quiflapon sodium (MK591) influences cAMP response element-binding protein but not Sp1.
Hyperoxia groups of mice treated with Quiflapon sodium (MK591) (20, 40 mg/kg) show alveolarization that resembles that of room air controls while untreated hyperoxia groups show definite evidence of aberrant alveolarization but no inflammation. Comparison of the Aβ-immunopositive areas between the placebo and Quiflapon sodium (MK591) (320 mg/kg)-treated group reveals a statistically significant reduction of the amyloid burden in the treated mice. Quiflapon sodium also has a significant reduction in brain levels of IL-1β. Mice treated with Quiflapon sodium show a statistically significant decrease in the steady-state levels of total CREB and its phosphorylated form at Ser133.
喹夫拉朋钠
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-50714 | Quiflapon sodium | | 1 mg | 465元 |
| 2024/04/30 | HY-50714 | 喹夫拉朋钠
Quiflapon sodium | 147030-01-1 | 5mg | 950元 |
喹夫拉朋钠
生产厂家
全球有 58家供应商
喹夫拉朋钠国内生产厂家
147030-01-1, 喹夫拉朋钠 相关搜索:
- Sulfur & Selenium Compounds
- Pharmaceuticals
- Intermediates & Fine Chemicals
- Heterocycles
- Aromatics
- C34H34ClN2NaO3S
- C34H34ClN2O3SNa
- 喹夫拉朋钠
- 147030-01-1
- MK-591 sodium
- QUIFLAPON SODIUM (MK591)
- QUIFLAPON SODIUM; MK-591; MK 591
- Quiflapon SodiuM
- MK 591
- 1-[(4-Chlorophenyl)Methyl]-3-[(1,1-diMethylethyl)thio]-α,α-diMethyl-5-(2-quinolinylMethoxy)-1H-Indole-2-propanoic Acid SodiuM Salt
- sodium 3-[1-[(4-chlorophenyl)methyl]-5-(quinolin-2-ylmethoxy)-3-tert-butylsulfanyl-indol-2-yl]-2,2-dimethyl-propanoate