PHE-MET-ARG-PHE AMIDE
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- CAS号:
- 64190-70-1
- 英文名:
- FMRF AMIDE
- 英文别名:
- FMRF-NH2;MFRF amide;FMRF AMIDE;neuropeptide C;PHE-MET-ARG-PHE-NH2;PHE-MET-ARG-PHE AMIDE;H-PHE-MET-ARG-PHE-NH2;L-Phe-L-Met-L-Arg-Phe-NH2;FMRF-AMIDE 1 1/2ACOH 2H2O;L-Phe-L-Met-L-Arg-L-Phe-NH2
- 中文名:
- PHE-MET-ARG-PHE AMIDE
- 中文别名:
- 心脏兴奋肽;神经肽 C;苯丙氨酸丙烯酰胺
- CBNumber:
- CB1231122
- 分子式:
- C29H42N8O4S
- 分子量:
- 598.76
- MOL File:
- 64190-70-1.mol
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PHE-MET-ARG-PHE AMIDE化学性质
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密度:
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1.32±0.1 g/cm3(Predicted)
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储存条件:
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−20°C
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溶解度:
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Soluble in DMSO
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酸度系数(pKa):
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13.35±0.46(Predicted)
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PHE-MET-ARG-PHE AMIDE性质、用途与生产工艺
Phe-Met-Arg-Phe, amide 是一种神经肽，在肽能神经元中激活 K+电流，ED50 为23 nM，这种作用具有剂量依赖性。
ED50: 23 nM (K
+
current)
In the molluscan central nervous system, Phe-Met-Arg-Phe, amide (FMRFa) acts on K
+
channels in sensory, motor-, and neuroendocrine neurones. Phe-Met-Arg-Phe, amide activates a novel K
+
current that is characterized by a combined voltage- and receptor-dependent gating mechanism, with both factors being necessary for opening of the channels. Phe-Met-Arg-Phe, amide (1 μM) significantly inhibits glucose stimulated (300 mg/dL) insulin release (p<0.005) and somatostatin release (p<0.01) from the isolated perfused pancreas. Phe-Met-Arg-Phe, amide (FMRF-NH2) (1 and 10 μM) is without effect on glucagon secretion, either in low glucose (50 mg/dL), high glucose (300 mg/dL), or during arginine stimulation (5 mM).
Phe-Met-Arg-Phe, amide (FMRFamide) stimulates growth hormone secretion in conscious OVX rats. The presence of Phe-Met-Arg-Phe, amide-like immunoreactivity in neuronal elements in the hypothalamus suggested a role for this in the hypothalamic control of the anterior pituitary function. The injection of 200 ng (313.8 picomoles) of FMRFamide (in 2 uL) produces a significantly increased plasma GH 15 min after injection. The GH-increasing effect of 400-800 ng (627-1255 picomoles) of FMRFamide is already developed after 5 min and lasted up to 30 min.
PHE-MET-ARG-PHE AMIDE
上下游产品信息
上游原料
下游产品
PHE-MET-ARG-PHE AMIDE
生产厂家
64190-70-1, PHE-MET-ARG-PHE AMIDE 相关搜索:
- 细胞生物学
- Invertebrate Neuropeptides
- Peptides
- Other Neuropeptides
- Biochemicals and Reagents
- Amino Acids and Peptides
- BioChemical
- 苯丙氨酸丙烯酰胺
- 心脏兴奋肽
- 神经肽 C
- 64190-70-1
- (S)-N-((S)-1-Amino-1-oxo-3-phenylpropan-2-yl)-2-((S)-2-((S)-2-amino-3-phenylpropanamido)-4-(methylthio)butanamido)-5-guanidinopentanamide
- Phe-Met-Arg-Phe amide, ≥95% (HPLC)
- L-Phenylalaninamide,L-phenylalanyl-L-methionyl-L-arginyl-
- H-PHE-MET-ARG-PHE-NH2
- FMRF-NH2
- FMRF AMIDE MOLLUSCAN CARDIOEXCITATORY PEPTIDE
- FMRF-AMIDE 1 1/2ACOH 2H2O
- FMRF AMIDE
- Neuropeptide C (Macrocallista nimbosa cardioexcitatory)
- Cardioexcitatory peptide (mollusk)
- (2S)-N-[(2S)-1-azanyl-1-oxo-3-phenyl-propan-2-yl]-2-[[2-[[(2S)-2-azanyl-3-phenyl-propanoyl]amino]-4-methylsulfanyl-butanoyl]amino]-5-[bis(azanyl)methylideneamino]pentanamide
- (2S)-N-[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]-2-[[2-[[(2S)-2-amino-3-phenylpropanoyl]amino]-4-methylsulfanylbutanoyl]amino]-5-(diaminomethylideneamino)pentanamide
- (2S)-N-[(1S)-2-amino-1-(benzyl)-2-keto-ethyl]-2-[[2-[[(2S)-2-amino-3-phenyl-propanoyl]amino]-4-(methylthio)butanoyl]amino]-5-guanidino-valeramide
- MFRF amide
- L-Phe-L-Met-L-Arg-Phe-NH2
- L-Phe-L-Met-L-Arg-L-Phe-NH2
- FMRF amide, Molluscan cardioexcitatory neuropeptide
- neuropeptide C
- L-PHENYLALANYL-L-METHIONYL-L-ARGINYL-L-PHENYLALANINAMIDE)
- 6-O-?D-Glucopyranosyl-D-glucitol
- PHE-MET-ARG-PHE-NH2 1/2ACOH 2H2O
- PHE-MET-ARG-PHE-NH2
- PHE-MET-ARG-PHE AMIDE
- MOLLUSCAN CARDIOEXCITATORY PEPTIDE
- MOLLUSCAN CARDIOEXCITATORY NEUROPEPTIDE 1 1/2 ACOH 2H2O
- MOLLUSCAN CARDIOEXCITATORY NEUROPEPTIDE