CINACIGUAT
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- CAS号:
- 329773-35-5
- 英文名:
- 4-[N-(4-Carboxybutyl)-N-[2-[2-[4-(2-phenylethyl)benzyloxy]phenyl]ethyl]aMinoMethyl]benzoic acid
- 英文别名:
- CS-778;Cinaciguat;BAY 58-2667;Cinaciguat
BAY-58-2667;Cinaciguat,Inhibitor,inhibit,Guanylate Cyclase;4-(((4-Carboxybutyl)(2-((4-phenethylbenzyl)oxy)phenethyl)amino)methyl)benzoic acid;4-[N-(4-Carboxybutyl)-N-[2-[2-[4-(2-phenylethyl)benzyloxy]phenyl]ethyl]aMinoMethyl]benzoic acid;4-[[(4-Carboxybutyl)[2-[2-[[4-(2-phenylethyl)phenyl]methoxy]phenyl]ethyl]amino]methyl]-benzoic acid;Benzoic acid, 4-[[(4-carboxybutyl)[2-[2-[[4-(2-phenylethyl)phenyl]methoxy]phenyl]ethyl]amino]methyl]-
- 中文名:
- CINACIGUAT
- 中文别名:
- 化合物CINACIGUAT;CINACIGUAT,鸟苷酸环化酶 (GC) 活化剂;GUANYLATE CYCLASE激活剂(CINACIGUAT);4-(((4-羧丁基)(2((4-苯乙基苄基)氧基)苯乙基)氨基)甲基)苯甲酸;4-[[(4-羧基丁基)[2-[2-[[4-(2-苯基乙基)苯基]甲氧基]苯基]乙基]氨基]甲基]苯甲酸
- CBNumber:
- CB12563263
- 分子式:
- C36H39NO5
- 分子量:
- 565.7
- MOL File:
- 329773-35-5.mol
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CINACIGUAT化学性质
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储存条件:
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Inert atmosphere,Store in freezer, under -20°C
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溶解度:
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Soluble in DMSO
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形态:
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Powder
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CINACIGUAT性质、用途与生产工艺
Cinaciguat hydrochloride是一种不依赖于一氧化氮的鸟苷酸环化酶 (GC) 活化剂，Kd 值为3.2 nM。
Cinaciguat (10 μM) significantly enhances intracellular cGMP generation. Cinaciguat does not dose-dependent effects on cell contraction and calcium transients.
Cinaciguat (10 mg/kg/day, p.o.) treatment in diabetic rats does not influence blood glucose levels, but leads to attenuated water intake. Cinaciguat treatment alleviates diabetes mellitus related oxidative stress, protects against DM related alteration of the NO-sGC-cGMP-PKG signalling, and alleviates DM related myocardium hypertrophy and apoptosis. Cinaciguat (1-10-100 nM) induces concentration-dependent relaxations in strips from both WT and apo-sGC mice, but does not have any effect on phasic activity induced by PGF
2α
in WT or apo-sGC strips.
CINACIGUAT
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-14181 | CINACIGUAT
Cinaciguat | 329773-35-5 | 2mg | 620元 |
| 2024/04/30 | HY-14181 | CINACIGUAT
Cinaciguat | 329773-35-5 | 5mg | 1300元 |
329773-35-5, CINACIGUAT 相关搜索:
- Inhibitors
- 高端化学
- 细胞生物学试剂
- 小分子抑制剂，天然产物
- 小分子抑制剂
- C36H39NO5
- CINACIGUAT,鸟苷酸环化酶 (GC) 活化剂
- 4-(((4-羧丁基)(2((4-苯乙基苄基)氧基)苯乙基)氨基)甲基)苯甲酸
- 化合物CINACIGUAT
- 4-[[(4-羧基丁基)[2-[2-[[4-(2-苯基乙基)苯基]甲氧基]苯基]乙基]氨基]甲基]苯甲酸
- GUANYLATE CYCLASE激活剂(CINACIGUAT)
- 329773-35-5
- Cinaciguat,Inhibitor,inhibit,Guanylate Cyclase
- 4-(((4-Carboxybutyl)(2-((4-phenethylbenzyl)oxy)phenethyl)amino)methyl)benzoic acid
- Benzoic acid, 4-[[(4-carboxybutyl)[2-[2-[[4-(2-phenylethyl)phenyl]methoxy]phenyl]ethyl]amino]methyl]-
- CS-778
- Cinaciguat
BAY-58-2667
- 4-[[(4-Carboxybutyl)[2-[2-[[4-(2-phenylethyl)phenyl]methoxy]phenyl]ethyl]amino]methyl]-benzoic acid
- Cinaciguat
- BAY 58-2667
- 4-[N-(4-Carboxybutyl)-N-[2-[2-[4-(2-phenylethyl)benzyloxy]phenyl]ethyl]aMinoMethyl]benzoic acid