B-Raf 抑制剂 1 二盐酸盐
|
|
|
- CAS号:
- 1191385-19-9
- 英文名:
- 1,5-IsoquinolinediaMine, N1-(4-chlorophenyl)-6-Methyl-N5-[3-(9H-purin-6-yl)-2-pyridinyl]-, (Hydrochloride) (1:2)
- 英文别名:
- MFCD18782676;5-isoquinolinediamine;B-Raf inhibitor 1 2HCl;Raf inhibitor 1 dihydrochloride;B-RAF Inhibitor 1 hydrochloride;B-Raf inhibitor 1 dihydrochloride;n1-(4-chlorophenyl)-6-methyl-n5-[3-(9h-purin-6-yl)-2-pyridinyl]-;N1-(4-CHLOROPHENYL)-6-METHYL-N5-[3-(9H-PURIN-6-YL)-2-PYRIDINYL]-1,5-ISOQUINOLINEDIAMINE 2HCL;N1-(4-Chlorophenyl)-6-methyl-N5-[3-(9H-purin-6-yl)-2-pyridyl]isoquinoline-1,5-diamine dihydroc;N1-(4-Chlorophenyl)-6-methyl-N5-[3-(9H-purin-6-yl)-2-pyridinyl]-1,5-isoquinolinediamine dihydrochloride
- 中文名:
- B-Raf 抑制剂 1 二盐酸盐
- 中文别名:
- B-RAF 抑制剂 1 二盐酸盐;化合物B-RAF INHIBITOR 1 DIHYDROCHLORIDE;N5-(3-(9H-嘌呤-6-基)吡啶-2-基)-N1-(4-氯苯基)-6-甲基异喹啉-1,5-二胺二盐酸盐
- CBNumber:
- CB12625204
- 分子式:
- C26H21Cl3N8
- 分子量:
- 551.87
- MOL File:
- 1191385-19-9.mol
|
|
|
B-Raf 抑制剂 1 二盐酸盐化学性质
-
储存条件:
-
Store at -20°C
-
|
-
溶解度:
-
Soluble in DMSO
-
|
-
形态:
-
Powder
-
|
B-Raf 抑制剂 1 二盐酸盐性质、用途与生产工艺
B-Raf inhibitor 1 (Compound 13)是一种IIA型Raf抑制剂，与DFG-out构象结合，对B-Raf(WT)，B-Raf(V600E)和C-Raf的ki分别为1 nM，1 nM和0.3 nM。
| Target | Value |
C-Raf
(Cell-free assay)
|
0.3 nM(Ki)
|
B-Raf(WT)
(Cell-free assay)
|
1 nM(Ki)
|
B-Raf(V600E)
(Cell-free assay)
|
1 nM(Ki)
|
B-Raf inhibitor 1 (Compound 13) inhibits A375 and HCT-116 proliferation with IC
50
s of 0.31 and 0.72 μM, respectively. B-Raf inhibitor 1 (Compound 13) binds to and stabilizes B-Raf in a DFG-out, inactive conformation in which the ATP pocket is partially filled by Phe595 and Gly596 from the DFG motif. B-Raf inhibitor 1 (Compound 13) additionally exhibits low micromolar inhibition against wild type B-Raf cell lines, which may be due to off-target kinase activities or alternatively to pan-Raf inhibition, including Raf dimers.
B-Raf 抑制剂 1 二盐酸盐
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | S6660 | [N/A]
B-Raf inhibitor 1 (Compound 13) dihydrochloride | 1191385-19-9 | 5mg | 1285.95元 |
| 2024/04/30 | S6660 | [N/A]
B-Raf inhibitor 1 (Compound 13) dihydrochloride | 1191385-19-9 | 25mg | 5627.35元 |
1191385-19-9, B-Raf 抑制剂 1 二盐酸盐 相关搜索:
- 药靶配体
- C26H21Cl3N8
- B-RAF 抑制剂 1 二盐酸盐
- N5-(3-(9H-嘌呤-6-基)吡啶-2-基)-N1-(4-氯苯基)-6-甲基异喹啉-1,5-二胺二盐酸盐
- 化合物B-RAF INHIBITOR 1 DIHYDROCHLORIDE
- 1191385-19-9
- Raf inhibitor1,Raf inhibitor-1,inhibit,Raf,Raf inhibitor 1 dihydrochloride,Inhibitor,Raf inhibitor 1,Raf kinases
- B-RAF Inhibitor 1 hydrochloride
- Raf inhibitor 1 dihydrochloride
- 1,5-IsoquinolinediaMine, N1-(4-chlorophenyl)-6-Methyl-N5-3-(9H-purin-6-yl)-2-pyridinyl-, (Hydrochloride) (1
- n1-(4-chlorophenyl)-6-methyl-n5-[3-(9h-purin-6-yl)-2-pyridinyl]-
- B-RAF INHIBITOR 1 2HCL;1;5-ISOQUINOLINEDIAMINE; N1-(4-CHLOROPHENYL)-6-METHYL-N5-[3-(9H-PURIN-6-YL)-2-PYRIDINYL]-; HYDROCHLORIDE (1:2)
- 5-isoquinolinediamine
- N1-(4-CHLOROPHENYL)-6-METHYL-N5-[3-(9H-PURIN-6-YL)-2-PYRIDINYL]-1,5-ISOQUINOLINEDIAMINE 2HCL
- B-Raf inhibitor 1 2HCl
- 1,5-IsoquinolinediaMine, N1-(4-chlorophenyl)-6-Methyl-N5-[3-(9H-purin-6-yl)-2-pyridinyl]-, (Hydrochloride) (1:2)
- N1-(4-Chlorophenyl)-6-methyl-N5-[3-(9H-purin-6-yl)-2-pyridyl]isoquinoline-1,5-diamine dihydroc
- N1-(4-Chlorophenyl)-6-methyl-N5-[3-(9H-purin-6-yl)-2-pyridinyl]-1,5-isoquinolinediamine dihydrochloride
- N5-(3-(9H-Purin-6-yl)pyridin-2-yl)-N1-(4-chlorophenyl)-6-methylisoquinoline-1,5-diamine dihydrochloride
- B-Raf inhibitor 1 dihydrochloride
- MFCD18782676