944547-46-0
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- CAS号:
- 944547-46-0
- 英文名:
- Mycro3
- 英文别名:
- Mycro3;Mycro-3, >98%;dimerization,Mycro 3,pancreatic,inhibit,adenocarcinoma,ductal,c-Myc,Inhibitor,PDA,Autophagy,Mycro3,MAX,Myc;Ethyl 5-(7-(chlorodifluoromethyl)-5-(furan-2-yl)pyrazolo[1,5-a]pyrimidine-2-carboxamido)-1-phenyl-1H-pyrazole-4-carboxylate;ethyl 5-[[7-[chloro(difluoro)methyl]-5-(furan-2-yl)pyrazolo[1,5-a]pyrimidine-2-carbonyl]amino]-1-phenylpyrazole-4-carboxylate;1H-Pyrazole-4-carboxylic acid, 5-[[[7-(chlorodifluoromethyl)-5-(2-furanyl)pyrazolo[1,5-a]pyrimidin-2-yl]carbonyl]amino]-1-phenyl-, ethyl ester
- 中文名:
- 944547-46-0
- 中文别名:
- 化合物MYCRO-3;C-MYC抑制剂(MYCRO 3);5-(7-(氯二氟甲基)-5-(呋喃-2-基)吡唑并[1,5-A]嘧啶-2-甲酰胺基)-1-苯基-1H-吡唑-4-羧酸乙酯
- CBNumber:
- CB13067564
- 分子式:
- C24H17ClF2N6O4
- 分子量:
- 526.88
- MOL File:
- 944547-46-0.mol
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944547-46-0化学性质
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密度:
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1.53±0.1 g/cm3(Predicted)
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储存条件:
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Sealed in dry,Store in freezer, under -20°C
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溶解度:
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DMSO : ≥ 100 mg/mL (189.80 mM)
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酸度系数(pKa):
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6.95±0.46(Predicted)
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944547-46-0性质、用途与生产工艺
Mycro 3 是一种有效的选择 Myc-Max 二聚化抑制剂。Mycro 3 可用于胰腺癌的研究。
Mycro 3 is a potent and selective c-Myc inhibitor in whole cell assays, with weak inhibitory activity against Activator protein 1 (AP-1). Mycro 3 has a superior specificity profile to its predecessors. Mycro 3 inhibits the interaction between c-Myc and Max. Mycro 3 has high selectivity and inhibits c-Myc/Max dimerization and conjugation with DNA. Mycro 3 exhibits an excellent specificity with IC
50
s of 0.25 and 9.0 µM for cells with intact Myc alleles and Myc-null cells, respectively.
Mycro 3 (100 mg/kg; oral administration; daily for two months) induces marked shrinkage of pancreatic ductal adenocarcinoma (PDA), increases cancer cell apoptosis, and reduces cell proliferation. Tumor growth is also drastically attenuated in Mycro 3-treated NOD/SCID mice carrying orthotopic or heterotopic xenografts of human pancreatic cancer cells.
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Animal Model:
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Moribund
Pdx1-cre/KRAS
* mice bearing pancreatic ductal adenocarcinoma (PDA)
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Dosage:
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100 mg/kg
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Administration:
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Oral administration; daily for two months
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Result:
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Increased survival time.
Mycro 3 administration was discontinued after two months, the mouse survived for an additional month.
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944547-46-0
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | XW94454746002 | 试剂Mycro-3
Mycro-3 | | 10mg | 352元 |
| 2024/04/30 | XW94454746001 | 试剂Mycro-3
Mycro-3 | | 25mg | 439元 |
944547-46-0, 944547-46-0 相关搜索:
- 药靶配体
- 细胞生物学试剂
- C24H17ClF2N6O4
- 5-(7-(氯二氟甲基)-5-(呋喃-2-基)吡唑并[1,5-A]嘧啶-2-甲酰胺基)-1-苯基-1H-吡唑-4-羧酸乙酯
- 化合物MYCRO-3
- C-MYC抑制剂(MYCRO 3)
- 944547-46-0
- dimerization,Mycro 3,pancreatic,inhibit,adenocarcinoma,ductal,c-Myc,Inhibitor,PDA,Autophagy,Mycro3,MAX,Myc
- Ethyl 5-(7-(chlorodifluoromethyl)-5-(furan-2-yl)pyrazolo[1,5-a]pyrimidine-2-carboxamido)-1-phenyl-1H-pyrazole-4-carboxylate
- 1H-Pyrazole-4-carboxylic acid, 5-[[[7-(chlorodifluoromethyl)-5-(2-furanyl)pyrazolo[1,5-a]pyrimidin-2-yl]carbonyl]amino]-1-phenyl-, ethyl ester
- Mycro-3, >98%
- ethyl 5-[[7-[chloro(difluoro)methyl]-5-(furan-2-yl)pyrazolo[1,5-a]pyrimidine-2-carbonyl]amino]-1-phenylpyrazole-4-carboxylate
- Mycro3