化合物UK371804
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- CAS号:
- 256477-09-5
- 英文名:
- UK-371804
- 英文别名:
- UK-371804;Urokinase inhitibor 1;Urokinase inhibitor 1;UK-371804 (Urokinase inhitibor 1);UK 371804,UK-371804,Inhibitor,PAI-1,inhibit,Plasminogen activator inhibitor-1;N-[[1-[(Aminoiminomethyl)amino]-4-chloro-7-isoquinolinyl]sulfonyl]-2-methylalanine;Alanine, N-[[1-[(aminoiminomethyl)amino]-4-chloro-7-isoquinolinyl]sulfonyl]-2-methyl-
- 中文名:
- 化合物UK371804
- 中文别名:
- 化合物UK371804
- CBNumber:
- CB13160423
- 分子式:
- C14H16ClN5O4S
- 分子量:
- 385.83
- MOL File:
- 256477-09-5.mol
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化合物UK371804化学性质
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储存条件:
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Store at -20°C
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溶解度:
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DMSO:5.0(Max Conc. mg/mL);2.59(Max Conc. mM)
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形态:
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A crystalline solid
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CAS 数据库:
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256477-09-5
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化合物UK371804性质、用途与生产工艺
UK-371804是尿嘧啶型纤溶酶原激活物 (uPA) 的抑制剂，Ki值为10 nM。
UK-371804 is able to inhibit exogenous uPA in human chronic wound fluid (IC
50
=0.89 μM). UK-371804 has its excellent enzyme potency (K
i
=10 nM) and selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin).
In a porcine acute excisional wound model, following topical delivery, UK-371804 is able to penetrate into pig wounds and inhibit exogenous uPA activity with no adverse effect on wound healing parameters. Concentrations of UK-371804 in the dermis are 41.8 μM.
化合物UK371804
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-101214 | UK-371804 | 256477-09-5 | 10mg | 2100元 |
| 2024/04/30 | HY-101214 | UK-371804 | 256477-09-5 | 50mg | 6500元 |
256477-09-5, 化合物UK371804 相关搜索:
- 生物试剂
- C14H16ClN5O4S
- 化合物UK371804
- 256477-09-5
- UK 371804,UK-371804,Inhibitor,PAI-1,inhibit,Plasminogen activator inhibitor-1
- N-[[1-[(Aminoiminomethyl)amino]-4-chloro-7-isoquinolinyl]sulfonyl]-2-methylalanine
- Alanine, N-[[1-[(aminoiminomethyl)amino]-4-chloro-7-isoquinolinyl]sulfonyl]-2-methyl-
- UK-371804 (Urokinase inhitibor 1)
- Urokinase inhitibor 1
- Urokinase inhibitor 1
- UK-371804