ML380
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- CAS号:
- 1627138-52-6
- 英文名:
- N-ethyl-1-(1H-indazol-5-ylsulfonyl)-N-[[2-(trifluoromethyl)phenyl]methyl]piperidine-4-carboxamide
- 英文别名:
- ML380;N-ethyl-1-(1H-indazol-5-ylsulfonyl)-N-[[2-(trifluoromethyl)phenyl]methyl]piperidine-4-carboxamide;4-Piperidinecarboxamide, N-ethyl-1-(1H-indazol-5-ylsulfonyl)-N-[[2-(trifluoromethyl)phenyl]methyl]-;positive,ML380,Muscarinic acetylcholine receptor,allosteric,inhibit,ACh,modulator,Inhibitor,mAChR,PAM
- 中文名:
- ML380
- 中文别名:
- 化合物ML380;ML380 ; ML 380 ; ML-380
- CBNumber:
- CB13414100
- 分子式:
- C23H25F3N4O3S
- 分子量:
- 494.53
- MOL File:
- 1627138-52-6.mol
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ML380化学性质
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沸点:
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661.2±65.0 °C(Predicted)
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密度:
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1.388±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO: 100 mg/mL (202.21 mM)
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酸度系数(pKa):
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12.84±0.40(Predicted)
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ML380性质、用途与生产工艺
ML380 是一种有效的，亚型选择性和可透过血脑屏障的 M5 mAChR 正变构调节剂 (PAM)，对人和大鼠 M5 的 EC50 值分别为 190 和 610 nM。ML380 对 M1 和 M3 mAChR 亚型具有中等选择性。ML380 可以增加 Ach 对 M5 mAChR 的亲和力。
IC50: 190 nM (hM5), 610 nM (rM5)
ML380 (0.01 nM-100 μM) robustly stimulates inositol phosphate (IP) accumulation and Ca
2+
mobilization in CHO-hM
5
cells, with pEC
50
s of 5.33 and 5.71, respectively.
ML380 (0.01-30 μM) increases the ACh-stimulated IP accumulation and Ca
2+
mobilization in CHO-hM
5
cells.
ML380 (1 mg/kg; i.v.) displays high clearance (66 mL/min/kg), a moderate volume of distribution (1.6 L/kg), and a short half-life (t
1/2
, 22 min) in rats.
ML380
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-12439 | ML380
ML380 | 1627138-52-6 | 5mg | 690元 |
| 2024/04/30 | HY-12439 | ML380 | | 10 mM * 1 mLin DMSO | 759元 |
1627138-52-6, ML380 相关搜索:
- 化合物ML380
- ML380 ; ML 380 ; ML-380
- 1627138-52-6
- 4-Piperidinecarboxamide, N-ethyl-1-(1H-indazol-5-ylsulfonyl)-N-[[2-(trifluoromethyl)phenyl]methyl]-
- positive,ML380,Muscarinic acetylcholine receptor,allosteric,inhibit,ACh,modulator,Inhibitor,mAChR,PAM
- ML380
- N-ethyl-1-(1H-indazol-5-ylsulfonyl)-N-[[2-(trifluoromethyl)phenyl]methyl]piperidine-4-carboxamide