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5-chloro-N'-[2-(trifluoromethyl)phenyl]sulfonyl-1-benzofuran-2-carbohydrazide
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- CAS号:
- 406191-34-2
- 英文名:
- 5-chloro-N'-[2-(trifluoromethyl)phenyl]sulfonyl-1-benzofuran-2-carbohydrazide
- 英文别名:
- BCATc Inhibitor 2;5-chloro-N'-[2-(trifluoromethyl)phenyl]sulfonyl-1-benzofuran-2-carbohydrazide;2-Benzofurancarboxylic acid, 5-chloro-, 2-[[2-(trifluoromethyl)phenyl]sulfonyl]hydrazide;cytosolic,neurodegenerative,human,BCATc Inhibitor-2,mitochondrial,disease,rBCATc,Inhibitor,BCAT,BCATc Inhibitor 2,rBCATm,inhibit,hBCATc,BCATc Inhibitor2
- 中文名:
- 5-chloro-N'-[2-(trifluoromethyl)phenyl]sulfonyl-1-benzofuran-2-carbohydrazide
- 中文别名:
- 化合物BCATC INHIBITOR 2
- CBNumber:
- CB13622657
- 分子式:
- C16H10ClF3N2O4S
- 分子量:
- 418.7748096
- MOL File:
- 406191-34-2.mol
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5-chloro-N'-[2-(trifluoromethyl)phenyl]sulfonyl-1-benzofuran-2-carbohydrazide化学性质
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储存条件:
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Store at -20°C, protect from light
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溶解度:
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≤10mg/ml in ethanol;20mg/ml in DMSO;25mg/ml in dimethyl formamide
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形态:
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crystalline solid
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5-chloro-N'-[2-(trifluoromethyl)phenyl]sulfonyl-1-benzofuran-2-carbohydrazide性质、用途与生产工艺
BCATc Inhibitor 2 是一种选择性的分支链氨基转移酶 (BCAT) 抑制剂，可用于神经退行性疾病的研究。对 rBCATc，hBCATc 和 rBCATm 的 IC50 分别为 0.2 μM，0.8 μM 和 3.0 μM。BCATc 也叫 BCAT1，存在于细胞质基质中的亚型。
IC50: 0.2 μM (rBCATc), 0.8 μM (hBCATc), 3.0 μM (rBCATm).
BCATc Inhibitor 2 decreases calcium influx in neuronal cultures with an IC
50
=4.8±1.2 μM.
BCATc Inhibitor 2 also blocks calcium influx into neuronal cells following inhibition of glutamate uptake, and demonstrates neuroprotective efficacy in vivo.
Following a 30 mg/kg subcutaneous injection to Lewis rats, BCATc Inhibitor 2 reaches a peak plasma concentration (Cmax) of 8.28 μg/mL at 0.5 h (t
max
). The mean plasma exposure (AUC) value is 19.9 μg h/mL, and the mean terminal half-life ranged from 12 to 15 h, indicating favorable PK parameters of BCATc Inhibitor 2.
5-chloro-N'-[2-(trifluoromethyl)phenyl]sulfonyl-1-benzofuran-2-carbohydrazide
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-116044 | BCATc Inhibitor 2 | | 1 mg | 681元 |
| 2024/04/30 | HY-116044 | 5-chloro-N'-[2-(trifluoromethyl)phenyl]sulfonyl-1-benzofuran-2-carbohydrazide
BCATc Inhibitor 2 | 406191-34-2 | 5mg | 1500元 |
5-chloro-N'-[2-(trifluoromethyl)phenyl]sulfonyl-1-benzofuran-2-carbohydrazide
生产厂家
406191-34-2, 5-chloro-N'-[2-(trifluoromethyl)phenyl]sulfonyl-1-benzofuran-2-carbohydrazide 相关搜索:
- 化合物BCATC INHIBITOR 2
- 406191-34-2
- cytosolic,neurodegenerative,human,BCATc Inhibitor-2,mitochondrial,disease,rBCATc,Inhibitor,BCAT,BCATc Inhibitor 2,rBCATm,inhibit,hBCATc,BCATc Inhibitor2
- 2-Benzofurancarboxylic acid, 5-chloro-, 2-[[2-(trifluoromethyl)phenyl]sulfonyl]hydrazide
- BCATc Inhibitor 2
- 5-chloro-N'-[2-(trifluoromethyl)phenyl]sulfonyl-1-benzofuran-2-carbohydrazide