Compound 48/80 (hydrochloride)
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- CAS号:
- 848035-21-2
- 英文名:
- Compound 48/80 (hydrochloride)
- 英文别名:
- C48/80 trihydrochloride;Compound 48/80 trihydrochlorid;Compound 48/80 (hydrochloride)
- 中文名:
- Compound 48/80 (hydrochloride)
- 中文别名:
- 化合物 T13623;复合物48/80三氯化氢
- CBNumber:
- CB14666319
- 分子式:
- C32H48Cl3N3O3
- 分子量:
- 629.10082
- MOL File:
- 848035-21-2.mol
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Compound 48/80 (hydrochloride)化学性质
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储存条件:
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Store at -20°C, sealed storage, away from moisture ,protect from light
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溶解度:
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Water: 100 mM
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形态:
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A solid
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Compound 48/80 (hydrochloride)性质、用途与生产工艺
Compound 48/80 trihydrochloride (C48/80 trihydrochloride) 是 N-甲基对甲氧基苯乙胺与甲醛缩合产物的混合物。Compound 48/80 trihydrochloride 也是一种组胺 (histamine) 释放剂和肥大细胞 (mast cell) 脱颗粒剂。Compound 48/80 trihydrochloride 抑制人血小板磷脂酰肌醇特异性磷脂酶 C (phosphatidylinositol-specific phospholipase C) 活性。
Compound 48/80 trihydrochloride (C48/80 trihydrochloride) inhibits both cytosolic and particulate phosphatidylinositol-specific phospholipase C activities with a similar efficiency; IC
50
values are 2.1 μg/ml (supernatant) and 5.0 μg /ml (particulate fraction). The aggregation of human platelets induced by ADP and PAF-acether is inhibited by Compound 48/80.
Compound 48/80 trihydrochloride (0.75 mg/kg; i.p.; Killed after 0.5, 3 or 6 h) increases serum serotonin, histamine and corticosterone levels at 0.5 h, but their increases were reduced thereafter.
Compound 48/80 trihydrochloride causes oxidative stress in rat adrenal gland through mast cell degranulation.
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Animal Model:
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7-week-old Wistar male rats (fasted for 24 hours)
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Dosage:
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0.75 mg/kg
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Administration:
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Intraperitoneal injection; Killed after 0.5, 3 or 6 h
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Result:
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Serum histamine and serotonin concentrations significantly higher than those in untreated control rats at 0.5 h after treatment. The increased serum histamine and serotonin concentrations in rats decreased time-dependently thereafter.
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Compound 48/80 (hydrochloride)
上下游产品信息
上游原料
下游产品
Compound 48/80 (hydrochloride)
生产厂家
848035-21-2, Compound 48/80 (hydrochloride) 相关搜索:
- 复合物48/80三氯化氢
- 化合物 T13623
- 848035-21-2
- Compound 48/80 trihydrochlorid
- C48/80 trihydrochloride
- Compound 48/80 (hydrochloride)