MMP-9-IN-1
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- CAS号:
- 502887-71-0
- 英文名:
- MMP-9-IN-1
- 英文别名:
- OUN87710;MMP-9-IN-1;OUN87710,MMP-9-IN-1;N-(4-(Difluoromethoxy)phenyl)-2-((6-oxo-4-propyl-1,6-dihydropyrimidin-2-yl)thio)acetamide;Acetamide, N-[4-(difluoromethoxy)phenyl]-2-[(1,6-dihydro-6-oxo-4-propyl-2-pyrimidinyl)thio]-;PEX,anti-metastatic,metastasis,MMP,Matrix metalloproteinases,tumor,MMP 9 IN 1,inhibit,MMP9IN1,MMP-9,Inhibitor,lung,cancer,hemopexin
- 中文名:
- MMP-9-IN-1
- 中文别名:
- 化合物MMP-9-IN-1;N-(4-(二氟甲氧基)苯基)-2-((6-氧代-4-丙基-1,6-二氢嘧啶-2-基)硫代)乙酰胺
- CBNumber:
- CB15821461
- 分子式:
- C16H17F2N3O3S
- 分子量:
- 369.39
- MOL File:
- 502887-71-0.mol
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MMP-9-IN-1化学性质
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密度:
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1.37±0.1 g/cm3(Predicted)
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储存条件:
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under inert gas (nitrogen or Argon) at 2-8°C
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溶解度:
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DMSO: 125 mg/mL (338.40 mM)
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酸度系数(pKa):
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7.80±0.50(Predicted)
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MMP-9-IN-1性质、用途与生产工艺
MMP-9-IN-1 (OUN87710)是一种 matrix metalloproteinase-9 (MMP-9) 的特异性抑制剂。MMP-9-IN-1 可选择性地靶向MMP-9的血红素(PEX)域，Kd值为2.1 μM。
| Target | Value |
MMP-9
(Cell-free assay)
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2.1 μM(Kd)
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MMP-9-IN-1 (compound 2; 100 μM; 14 hours) does not cause notable cytotoxicity.
MMP-9-IN-1 (compound 2; 10 μM) significantly inhibits cell proliferation of HT-1080 and MDA-MB-435 cells.
Cell Cytotoxicity Assay
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Cell Line:
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COS-1 monkey epithelial cell lines
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Concentration:
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100 μM
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Incubation Time:
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24 hours
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Result:
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Treatment did not cause notable cytotoxicity.
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Cell Proliferation Assay
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Cell Line:
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HT-1080 and MDA-MB-435 cancer cells expressing endogenous MMP-9
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Concentration:
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10 μM
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Incubation Time:
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9 days
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Result:
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Significant inhibition of cell proliferation.
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MMP-9-IN-1 (compound 2; 20 mg/kg; intraperitoneal and intratumoral injection alternately; 6 days/week; for 14 weeks) results in a profound delay in tumor growth in NCR-Nu mice bearing MDA-MB-435/GFP tumor.
MMP-9-IN-1 inhibits cancer cell metastasis in vivo.
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Animal Model:
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4-5 week-old female NCR-Nu mice bearing MDA-MB-435/GFP tumor
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Dosage:
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20 mg/kg
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Administration:
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Intraperitoneal and intratumoral injection alternately; 6 days/week; for 14 weeks,
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Result:
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Resulted in a profound delay in tumor growth.
Inhibited cancer cell metastasis.
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MMP-9-IN-1
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-135232 | MMP-9-IN-1
MMP-9-IN-1 | 502887-71-0 | 5mg | 2900元 |
| 2024/04/30 | S0769 | MMP-9-IN-1
MMP-9-IN-1 | 502887-71-0 | 5mg | 2970元 |
502887-71-0, MMP-9-IN-1 相关搜索:
- API
- 药靶配体
- N-(4-(二氟甲氧基)苯基)-2-((6-氧代-4-丙基-1,6-二氢嘧啶-2-基)硫代)乙酰胺
- 化合物MMP-9-IN-1
- 502887-71-0
- PEX,anti-metastatic,metastasis,MMP,Matrix metalloproteinases,tumor,MMP 9 IN 1,inhibit,MMP9IN1,MMP-9,Inhibitor,lung,cancer,hemopexin
- N-(4-(Difluoromethoxy)phenyl)-2-((6-oxo-4-propyl-1,6-dihydropyrimidin-2-yl)thio)acetamide
- OUN87710,MMP-9-IN-1
- Acetamide, N-[4-(difluoromethoxy)phenyl]-2-[(1,6-dihydro-6-oxo-4-propyl-2-pyrimidinyl)thio]-
- OUN87710
- MMP-9-IN-1