原苏木素A
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- CAS号:
- 102036-28-2
- 英文名:
- protosappanin A
- 英文别名:
- Sappanol B;protosappanin A;PROTOSAPPANIN A (PTA);3,10,11-Trihydroxy-6H-dibenz[b,d]oxocin-7(8H)-one;3,10,11-Trihydroxy-6H-dibenzo[b,d]oxocin-7(8H)-one;6H-Dibenz[b,d]oxocin-7(8H)-one, 3,10,11-trihydroxy-;Protosappanin A,inhibit,JAK,Inhibitor,STAT,Janus kinase
- 中文名:
- 原苏木素A
- 中文别名:
- 原苏木素A;原苏木素A标准品;原苏木素A对照品;3,10,11-三羟基-6H-二苯并[B,D]OXOCIN-7(8H)-酮
- CBNumber:
- CB21315574
- 分子式:
- C15H12O5
- 分子量:
- 272.25
- MOL File:
- 102036-28-2.mol
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原苏木素A化学性质
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熔点:
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254-255 °C
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沸点:
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613.1±55.0 °C(Predicted)
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密度:
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1.476±0.06 g/cm3(Predicted)
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储存条件:
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4°C, away from moisture and light
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溶解度:
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Soluble in DMSO
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酸度系数(pKa):
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9.01±0.20(Predicted)
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原苏木素A性质、用途与生产工艺
Protosappanin A (PTA)，是一种免疫制剂，是从 Caesalpinia sappan L 中分离得到的一种主要联苯化合物，通过下调 JAK2 和 STAT3 的磷酸化，抑制 JAK2/STAT3 依赖的炎症通路。
Protosappanin A (PTA: 12.5, 25, 50 μM, 24 hours) significantly inhibits the production of TNF-α and IL-1β in LPS-activated BV2 microglia. And the mRNA expressions of IL-6, IL-1β, and MCP-1 are reduced by PTA in a dose-dependent manner in BV2 microglial cell line.
Protosappanin A (PTA: 12.5, 25, 50 μM, 24 hours) suppresses JAK2/STAT3-dependent inflammation pathway through down-regulating the phosphorylation of JAK2 and STAT3, as well as STAT3 nuclear translocation against LPS treatment.
Protosappanin A (PTA: 12.5, 25, 50 μM, 24 hours) shows obvious effect on disturbing the interaction of transmembrane protein CD14 with Toll-like receptor-4, resulting in the inhibition of NF-κB-dependent oxidative and nitrative stress in LPS-induced BV2 microglia.
Western Blot Analysis
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Cell Line:
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Murine BV2 microglial cell line.
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Concentration:
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12.5, 25, 50 μM.
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Incubation Time:
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24 hours.
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Result:
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Inhibits the releases of NO, TNF-α and IL-1β in LPS-induced BV2 cells.
Attenuated IL-6, IL-1β and MCP-1 gene expressions in the LPS-induced BV2 cells.
Suppressed JAK2/STAT3 pathway activation in the LPS-induced BV2 cells.
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原苏木素A
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-113573 | 原苏木素A
Protosappanin A | 102036-28-2 | 1mg | 1850元 |
| 2024/04/30 | HY-113573 | 原苏木素A
Protosappanin A | 102036-28-2 | 5mg | 5500元 |
102036-28-2, 原苏木素A 相关搜索:
- 化合物
- 标准品，对照品
- 其它酚类
- 对照品
- 标准品，对照品
- 标准品-对照品
- 对照品，标准品，含量测定，药理研究
- 3,10,11-三羟基-6H-二苯并[B,D]OXOCIN-7(8H)-酮
- 原苏木素A标准品
- 原苏木素A对照品
- 原苏木素A
- 102036-28-2
- Protosappanin A,inhibit,JAK,Inhibitor,STAT,Janus kinase
- 3,10,11-Trihydroxy-6H-dibenzo[b,d]oxocin-7(8H)-one
- 6H-Dibenz[b,d]oxocin-7(8H)-one, 3,10,11-trihydroxy-
- PROTOSAPPANIN A (PTA)
- 3,10,11-Trihydroxy-6H-dibenz[b,d]oxocin-7(8H)-one
- Sappanol B
- protosappanin A