(S)-(-)-卡维地洛
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- CAS号:
- 95094-00-1
- 英文名:
- (S)-(-)-CARVEDILOL
- 英文别名:
- (S)-BM 14190;(S)-(-)-CARVEDILOL;Carvedilol S-IsoMer;Carvedilol Impurity 11;(S)Carvedilol,(S) Carvedilol;Carvedilol Impurity 11（(S) Isomer）;(2S)-1-(9H-carbazol-4-yloxy)-3-[2-(2-methoxyphenoxy)ethylamino]propan-2-ol;(-)-1-(9H-CARBAZOL-4-YLOXY)-3-[[2-(2-METHOXYPHENOXY)ETHYL]AMINO]-2-PROPANOL;(S)-1-(9H-Carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanol;(2S)-1-(9H-Carbazole-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]propane-2-ol
- 中文名:
- (S)-(-)-卡维地洛
- 中文别名:
- S-卡维地络;(S)-卡维地洛;卡维地洛S-异构体;化合物 T12794;卡维地洛杂质11(S异构体)
- CBNumber:
- CB2190419
- 分子式:
- C24H26N2O4
- 分子量:
- 406.47
- MOL File:
- 95094-00-1.mol
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(S)-(-)-卡维地洛化学性质
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熔点:
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114-115°C
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沸点:
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655.2±55.0 °C(Predicted)
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密度:
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1.250±0.06 g/cm3(Predicted)
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储存条件:
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-20°C Freezer
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溶解度:
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Acetic Acid (Slightly), DMSO (Slightly), Methanol (Slightly)
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形态:
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Solid
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酸度系数(pKa):
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13.90±0.20(Predicted)
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颜色:
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White to Off-White
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稳定性:
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Hygroscopic
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(S)-(-)-卡维地洛性质、用途与生产工艺
(S)-Carvedilol 是 Carvedilol 的 S 型异构体，是一种非选择性 β/α-1 受体阻断剂。(S)-Carvedilol 可以抵抗 Doxorubicin (DOX) 的血管或心脏毒性。
β/α-1 adrenergic receptor
The β-receptor blocking activity of (S)-Carvedilol is about 100 times greater than that of (R)-Carvedilol, whereas both enantiomers show equipotent potency as α-blockers.
(S)-Carvedilol significantly attenuates Doxorubicin (DOX)-induced cell death, apoptotic morphological changes, decrease the mitochondrial membrane potential and oxidative stress responses by increasing the superoxide dismutase and catalase activities, and decreasing malondialdehyde contents and reactive oxygen species levels via the PI3K/AKT/eNO synthase pathway in vitro.
(S)-Carvedilol treatment significantly upregulates the expression levels of p-eNOS in HUVECs.
用途
The optically active isomer of Carvedilol (C184625), a nonselective β-adrenergic blocker with a1-blocking activity. An antihypertensive used in the treatment of congestive heart failure.
(S)-(-)-卡维地洛
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/04/30 | HY-B0006B | (S)-(-)-卡维地洛
(S)-Carvedilol | 95094-00-1 | 5mg | 1100元 |
| 2024/04/30 | HY-B0006B | (S)-(-)-卡维地洛
(S)-Carvedilol | 95094-00-1 | 10mg | 1800元 |
95094-00-1, (S)-(-)-卡维地洛 相关搜索:
- Pharmaceuticals
- Intermediates & Fine Chemicals
- Chiral Reagents
- Heterocycles
- Aromatics
- API
- 杂质
- 卡维地洛杂质11(S异构体)
- 化合物 T12794
- S-卡维地络
- (S)-卡维地洛
- 卡维地洛S-异构体
- 95094-00-1
- (S)Carvedilol,(S) Carvedilol
- Carvedilol Impurity 11
- (S)-BM 14190
- (2S)-1-(9H-carbazol-4-yloxy)-3-[2-(2-methoxyphenoxy)ethylamino]propan-2-ol
- Carvedilol Impurity 11（(S) Isomer）
- (S)-(-)-CarvedilolQ: What is
(S)-(-)-Carvedilol Q: What is the CAS Number of
(S)-(-)-Carvedilol Q: What is the storage condition of
(S)-(-)-Carvedilol Q: What are the applications of
(S)-(-)-Carvedilol
- [S,(-)]-1-(9H-Carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanol
- (S)-1-(9H-Carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanol
- (2S)-1-(9H-Carbazole-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]propane-2-ol
- 2-Propanol, 1-(9H-carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-, (S)-
- 2-Propanol, 1-(9H-carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-, (2S)-
- (S)-(-)-CARVEDILOL
- Carvedilol S-IsoMer
- (-)-1-(9H-CARBAZOL-4-YLOXY)-3-[[2-(2-METHOXYPHENOXY)ETHYL]AMINO]-2-PROPANOL