Cilliobrevin D
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- CAS号:
- 1370554-01-0
- 英文名:
- Cilliobrevin D
- 英文别名:
- Cilliobrevin D;Cytoplasmic Dynein Inhibitor, Ciliobrevin D;Benzenepropanenitrile, 2,4-dichloro-α-(7-chloro-3,4-dihydro-4-oxo-2(1H)-quinazolinylidene)-β-oxo-;inhibit,melanosome,spindles,cytoplasmic,γ-tubulin,Inhibitor,dynein,ATPases,Ciliobrevin D,Hedgehog,peroxisomes,aggregation
- 中文名:
- Cilliobrevin D
- 中文别名:
- 化合物CILIOBREVIN D;2-(7-氯-4-氧代-3,4-二氢喹唑啉-2(1H)-叉基)-3-(2,4-氯苯基)-3-氧代丙腈
- CBNumber:
- CB22714664
- 分子式:
- C17H8Cl3N3O2
- 分子量:
- 392.62
- MOL File:
- 1370554-01-0.mol
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Cilliobrevin D化学性质
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沸点:
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591.8±50.0 °C(Predicted)
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密度:
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1.537±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO: 5 mg/mL (12.73 mM; ultrasonic and warming and heat to 80°C)
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酸度系数(pKa):
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5.99±0.20(Predicted)
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Cilliobrevin D性质、用途与生产工艺
Ciliobrevin D (compound 5) 是一种具有细胞渗透性、可逆性和特异性的 AAA+ (ATPases associated with diverse cellular activities) ATPase 运动肌 cytoplasmic dynein 的拮抗剂。Ciliobrevin D 可干扰初级纤毛的形成并阻止 Hedgehog (Hh) 信号传导。
| Target | Value |
cytoplasmic dynein
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Hedgehog
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Cells treated with Ciliobrevin D exhibits abnormal (unfocused, multipolar, or collapsed) spindles with disrupted γ-tubulin localization in NIH-3T3 cells. Similar Ciliobrevin-induced spindle defects are observed in HeLa cells, although to a lesser extent. Ciliobrevin D addition also reversibly disrupts the pre-formed spindles of metaphase-arrested cells and reduces overall microtubule levels.
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Ciliobrevin D reversibly inhibits melanosome aggregation, but the non-cilia-disrupting derivative had no discernible effect at comparable doses. Ciliobrevin D similarly abrogates the movement of peroxisomes in Drosophila S2 cells.
Knockdown of Dync1h1 or inactivation of dynein 1 by Ciliobrevin D in the testis in vivo perturbs spermatogenesis. Knockdown of Dync1h1 or the use of Ciliobrevin D to inactivate dynein 1 in the testis in vivo perturbs MT organization through changes in the spatial expression of EB1, perturbs F-actin organization, and perturbs distribution of adhesion protein complexes at the BTB, leading to a loss of BTB integrity. F-actin disorganization in the seminiferous epithelium following Dync1h1 knockdown or dynein 1 inactivation by Ciliobrevin D is mediated by changes in the spatiotemporal expression of actin regulatory proteins Arp3 and Eps8.
Cilliobrevin D
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| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | S9743 | Cilliobrevin D
Ciliobrevin D | 1370554-01-0 | 5mg | 1613.93元 |
| 2024/04/30 | S9743 | Cilliobrevin D
Ciliobrevin D | 1370554-01-0 | 25mg | 4832.94元 |
1370554-01-0, Cilliobrevin D 相关搜索:
- 药靶配体
- 抑制剂
- 2-(7-氯-4-氧代-3,4-二氢喹唑啉-2(1H)-叉基)-3-(2,4-氯苯基)-3-氧代丙腈
- 化合物CILIOBREVIN D
- 1370554-01-0
- inhibit,melanosome,spindles,cytoplasmic,γ-tubulin,Inhibitor,dynein,ATPases,Ciliobrevin D,Hedgehog,peroxisomes,aggregation
- Benzenepropanenitrile, 2,4-dichloro-α-(7-chloro-3,4-dihydro-4-oxo-2(1H)-quinazolinylidene)-β-oxo-
- Cytoplasmic Dynein Inhibitor, Ciliobrevin D
- Cilliobrevin D