UAMC 00039 DIHYDROCHLORIDE
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- CAS号:
- 697797-51-6
- 英文名:
- UAMC 00039 dihydrochloride
- 英文别名:
- UAMC00039;UAMC00039 2HCl;UAMC 00039;UAMC-00039;UAMC 0039 (hydrochloride);UAMC 00039 dihydrochloride;UAMC00039dihydrochloride, >98%;UAMC00039 DIHYDROCHLORIDE, >98%;(S)-2-Amino-4-((4-chlorobenzyl)amino)-1-(piperidin-1-yl)butan-1-one dihydrochloride;(2S)-2-Amino-4-[[(4-chlorophenyl)methyl]amino]-1-(1-piperidinyl)-1-butanone dihydrochloride;Inhibitor,UAMC-00039 dihydrochloride,UAMC 00039,UAMC00039 dihydrochloride,DPP,Dipeptidyl Peptidase,UAMC00039,inhibit,UAMC-00039
- 中文名:
- UAMC 00039 DIHYDROCHLORIDE
- 中文别名:
- UAMC 00039 二盐酸盐;DIPEPTIDYL PEPTIDASE II抑制剂;化合物UAMC 00039 DIHYDROCHLORIDE;(S)-2-氨基-4-((4-氯苄基)氨基)-1-(哌啶-1-基)丁-1-酮二盐酸盐
- CBNumber:
- CB23037577
- 分子式:
- C16H25Cl2N3O
- 分子量:
- 346.3
- MOL File:
- 697797-51-6.mol
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UAMC 00039 DIHYDROCHLORIDE化学性质
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储存条件:
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Inert atmosphere,Store in freezer, under -20°C
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溶解度:
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DMF: 2 mg/mL; DMSO: 14 mg/mL; Ethanol: 5 mg/mL; PBS (pH 7.2): 10 mg/mL
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形态:
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Powder
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UAMC 00039 DIHYDROCHLORIDE性质、用途与生产工艺
UAMC00039 dihydrochloride是高效，可逆，竞争性的dipeptidyl peptidase II抑制剂，IC50值为0.48 nM。
IC50: 0.48 nM (DPPII); Ki: 0.082 nM (DPPII)
UAMC00039 has an IC
50
of 0.48±0.04 nM and a high selectivity for DPPII compared to DPPIV (IC
50
=165±9 µM) and DPP activity not caused by DPPII or DPPIV. UAMC00039 seems a promising tool to unravel the function of DPPII as well as to validate its potential as a therapeutic target. The efficacy of a DPPII inhibitor in cell culture depends not only on the inhibitors’ potency towards the enzyme but also on its stability in the medium and its ability to enter the cell. UAMC00039 is stable for at least 48 h at 37 °C in culture medium and in DPPII assay buffer. The compound is able to enter PBMC within 1 min resulting in a concentration-dependent inhibition of intracellular DPPII activity without affecting the ‘non-DPPII’ DPP activity. 1 and 100 μM UAMC00039 inhibits DPPII activity of PBMC and U937 cells more than 90%.
A dose dependent inhibition of DPPII but not of DPPIV is observed in the peripheral organs of both the rats and the mice (after oral administration) and the rabbits (after IV administration). UAMC00039 tested orally at 2 mg/kg does not cause signs of acute toxicity and does not cause any significant changes in the following functions that are evaluated: general behaviour, body temperature, respiration, bleeding time, blood pressure, urine volume, liver function, fasting glucose and gastrointestinal parameters like acidity, motility and irritation.
UAMC 00039 DIHYDROCHLORIDE
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | XW69779751601 | 试剂UAMC00039 dihydrochloride
UAMC00039dihydrochloride | | 25mg | 728元 |
| 2024/04/30 | HY-101769 | UAMC 00039 DIHYDROCHLORIDE
UAMC00039 dihydrochloride | 697797-51-6 | 2mg | 800元 |
UAMC 00039 DIHYDROCHLORIDE
生产厂家
697797-51-6, UAMC 00039 DIHYDROCHLORIDE 相关搜索:
- 酶
- 细胞生物学试剂
- C16H24ClN3O2HCl
- UAMC 00039 二盐酸盐
- (S)-2-氨基-4-((4-氯苄基)氨基)-1-(哌啶-1-基)丁-1-酮二盐酸盐
- 化合物UAMC 00039 DIHYDROCHLORIDE
- DIPEPTIDYL PEPTIDASE II抑制剂
- 697797-51-6
- Inhibitor,UAMC-00039 dihydrochloride,UAMC 00039,UAMC00039 dihydrochloride,DPP,Dipeptidyl Peptidase,UAMC00039,inhibit,UAMC-00039
- (S)-2-Amino-4-((4-chlorobenzyl)amino)-1-(piperidin-1-yl)butan-1-one dihydrochloride
- (2S)-2-Amino-4-[[(4-chlorophenyl)methyl]amino]-1-(1-piperidinyl)-1-butanone dihydrochloride
- UAMC 0039 (hydrochloride)
- UAMC00039 2HCl
- UAMC00039dihydrochloride, >98%
- UAMC00039 DIHYDROCHLORIDE, >98%
- UAMC 00039;UAMC-00039
- UAMC00039
- UAMC 00039 dihydrochloride