MS049 (hydrochloride)
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- CAS号:
- 2095432-59-8
- 英文名:
- MS049 (hydrochloride)
- 英文别名:
- MS049 dihydrochloride;MS049 (hydrochloride)
- 中文名:
- MS049 (hydrochloride)
- 中文别名:
- 化合物 MS049 DIHYDROCHLORIDE
- CBNumber:
- CB24666710
- 分子式:
- C15H25ClN2O
- 分子量:
- 284.83
- MOL File:
- 2095432-59-8.mol
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MS049 (hydrochloride)化学性质
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溶解度:
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DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; PBS (pH 7.2): 10 mg/ml
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形态:
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A crystalline solid
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MS049 (hydrochloride)性质、用途与生产工艺
MS049 dihydrochloride 是一种高效、选择性和细胞活性的 PRMT4 和 PRMT6 双重抑制剂，IC50 分别为 34 nM 和 43 nM。MS049 dihydrochloride 降低了 HEK293 细胞的 Med12me2a 和 H3R2me2a 水平。MS049 dihydrochloride 对 HEK293 细胞无毒，并且没有影响其的生长。
MS049 dihydrochloride (0.1-10 μM; 20 hours) reduces the H3R2me2a mark in HEK293 cells in a concentration dependent manner (IC
50
=0.97±0.05 μM).
MS049 dihydrochloride (0.1-100 μM; 72 hours) inhibits endogenous PRMT4 methyltransferase activity in a concentration dependent manner resulting in reduced levels of cellular asymmetric arginine dimethylation of Med12 (Med12-Rme2a, IC
50
=1.4±0.1 μM) in HEK293 cells.
MS049 dihydrochloride is selective for PRMT4 and PRMT6 over a broad range of epigenetic modifiers, including other PRMTs, PKMTs, DNMTs, KDMs, and methyllysine/methylarginine reader proteins, and non-epigenetic targets.
Western Blot Analysis
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Cell Line:
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HEK293 cells
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Concentration:
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0.1, 1, 10 μM
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Incubation Time:
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20 hours
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Result:
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Reduced the H3R2me2a mark in HEK293 cells in a concentration dependent manner (IC
50
=0.97±0.05 μM).
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Western Blot Analysis
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Cell Line:
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HEK293 cells
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Concentration:
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0.1, 1, 10, 100 μM
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Incubation Time:
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72 hours
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Result:
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Reduced levels of cellular asymmetric arginine dimethylation of Med12 (Med12-Rme2a, IC
50
=1.4±0.1 μM) in HEK293 cells.
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MS049 (hydrochloride)
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上游原料
下游产品
MS049 (hydrochloride)
生产厂家
2095432-59-8, MS049 (hydrochloride) 相关搜索:
- 药靶配体
- 化合物 MS049 DIHYDROCHLORIDE
- 2095432-59-8
- MS049 dihydrochloride
- MS049 (hydrochloride)