组胺素 5
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- CAS号:
- 115966-68-2
- 英文名:
- Histatin 5
- 英文别名:
- Human histatin 5;Peptide F-A (human parotid saliva);Histatin 5 (synthetic human re-Hst5);L-Tyrosine, L-α-aspartyl-L-seryl-L-histidyl-L-alanyl-L-lysyl-L-arginyl-L-histidyl-L-histidylglycyl-L-tyrosyl-L-lysyl-L-arginyl-L-lysyl-L-phenylalanyl-L-histidyl-L-α-glutamyl-L-lysyl-L-histidyl-L-histidyl-L-seryl-L-histidyl-L-arginylglycyl-
- 中文名:
- 组胺素 5
- 中文别名:
- 组氨素5;富组蛋白5;组胺素 5;抑制剂多肽HISTATIN 5 (TFA)
- CBNumber:
- CB31120359
- 分子式:
- C133H195N51O33
- 分子量:
- 3036.29
- MOL File:
- 115966-68-2.mol
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组胺素 5化学性质
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密度:
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1.57±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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形态:
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Solid
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组胺素 5性质、用途与生产工艺
Histatin 5 抑制宿主基质金属蛋白酶 MMP-2 和 MMP-9 活性，IC50 分别为 0.57 和 0.25 μM。
IC50: 0.57 μM (MMP-2), 0.25 μM (MMP-9)
Histatin 5 is a member of a family of low-molecular-weight salivary proteins secreted by parotid, submandibular, and sublingual glands. Using biotinylated gelatin as a substrate, Histatin 5 inhibits the activity of the host matrix metalloproteinases MMP-2 and MMP-9 with IC
50
s of 0.57 and 0.25 μM, respectively. To localize the domain responsible for this inhibition, three peptides containing different regions of Histatin 5 are synthesized and tested as inhibitors of MMP-9. Peptides comprising residues 1 to 14 and residues 4 to 15 of Histatin 5 show much lower inhibitory activities (IC
50
, 21.4 and 20.5 μM, respectively), while a peptide comprising residues 9 to 22 showed identical activity to Histatin 5 against MMP-9. Kinetic analysis of the inhibition of the Arg-gingipain reveals that Histatin 5 is a competitive inhibitor, affecting only the K
m
with a K
i
of 15 μM. Histatin 5 is an inhibitor of mitochondrial respiration.The human salivary antifungal peptide Histatin 5 is taken up by
Candida albicans
cells and associates intracellularly with mitochondria. Histatin 5 inhibits respiration of isolated C.
albicans
mitochondria as well as the respiration of intact blastoconidia in a dose and time-dependent manner. Histatin 5 at a concentration of 33 μM inhibits state 2 respiration.
组胺素 5
上下游产品信息
上游原料
下游产品
115966-68-2, 组胺素 5 相关搜索:
- 目录肽
- 标准品
- 抑制剂多肽HISTATIN 5 (TFA)
- 组氨素5
- 富组蛋白5
- 组胺素 5
- 115966-68-2
- L-Tyrosine, L-α-aspartyl-L-seryl-L-histidyl-L-alanyl-L-lysyl-L-arginyl-L-histidyl-L-histidylglycyl-L-tyrosyl-L-lysyl-L-arginyl-L-lysyl-L-phenylalanyl-L-histidyl-L-α-glutamyl-L-lysyl-L-histidyl-L-histidyl-L-seryl-L-histidyl-L-arginylglycyl-
- Peptide F-A (human parotid saliva)
- Human histatin 5
- Histatin 5 (synthetic human re-Hst5)