HS014
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- CAS号:
- 207678-81-7
- 英文名:
- HS014
- 英文别名:
- HS014;mc4receptor antagonist;M.W. 1563.77 C71H94N20O17S2;Melanocortin 4 Receptor antagonist;(AC-CYS11,D-2-NAL14,CYS18)-BETA-MSH (11-22) AMIDE;Acetyl-(Cys11,D-2-Nal14,Cys18)-b-MSH (11-22) aMide;Acetyl-(Cys11,D-2-Nal14,Cys18)-β-MSH (11-22) amide;(ACETYL-CYS11-BETA-(2-NAPHTHYL)*-D-ALA14,CYS18)-BET;Acetyl-(Cys11,D-2-Nal14,Cys18)-Beta-MSH (11-22) amide;Acetyl-(Cys11,D-2-Nal14,Cys18)-β-MSH (11-22) aMide
HS014
- 中文名:
- HS014
- 中文别名:
- 受体拮抗剂多肽HS014;AC-CYS-GLU-HIS-D-2-NAL-ARG-TRP-GLY-CYS-PRO-PRO-LYS-ASP-NH2(DISULFIDE BRIDGE:CYS1-CYS8);N-乙酰基-L-半胱氨酰-L-A-谷氨酰-L-组氨酰-3-(2-萘基)-D-丙氨酰-L-精氨酰-L-色氨酰甘氨酰-L-半胱氨酰-L-脯氨酰-L-脯氨酰-L-赖氨酰-L-A-天冬氨酰胺环(1->8)-二硫醚
- CBNumber:
- CB3166949
- 分子式:
- C71H94N20O17S2
- 分子量:
- 1563.76
- MOL File:
- 207678-81-7.mol
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HS014化学性质
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密度:
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1.57±0.1 g/cm3(Predicted)
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储存条件:
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−20°C
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形态:
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solid
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酸度系数(pKa):
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4.07±0.10(Predicted)
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水溶解性:
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Soluble to 1 mg/ml in water
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HS014性质、用途与生产工艺
HS014 是一种高效、选择性的黑素皮质素-4 (MC4) 受体拮抗剂，对人 MC4、MC1、MC3 和 MC5 受体的 Ki 值分别为 3.16、108、54.4 和 694 nM。HS014 调节吗啡对小鼠行为的影响。HS014 增加自由喂养大鼠的食物摄取量。
The dose-effect curve of morphine for locomotor activity was shifted downwards in C57Bl/6 mice pretreated with HS014 and in A(y) mice. The dose-effect curve of morphine for antinociception is shifted two- and threefold to the left in C57Bl/6 mice pretreated with HS014 and in A(y) mice, respectively.
Pretreatment with HS014 blocks the effect of IL-1beta on food intake and respiratory exchange ratio (RER) at later time points (beyond 8 h post injection), as well as the hypoactivity and increases metabolic rate.
HS014
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2023/03/20 | HY-P1216 | HS014
HS014 | 207678-81-7 | 1 mg | 4500元 |
| 2023/03/20 | HY-P1216 | HS014
HS014 | 207678-81-7 | 5 mg | 13500元 |
HS014
生产厂家
全球有 68家供应商
HS014国内生产厂家
207678-81-7, HS014 相关搜索:
- Melanocortin receptor
- 药靶配体
- 多肽
- 目录肽
- 标准品
- Cytokines, Growth Factors and Hormones
- Melanocyte Stimulating Hormone (MSH)
- Hormones
- Pituitary Hormones
- Cell Signaling and Neuroscience
- Cell Biology
- BioChemical
- C71H94N20O17S2
- 受体拮抗剂多肽HS014
- AC-CYS-GLU-HIS-D-2-NAL-ARG-TRP-GLY-CYS-PRO-PRO-LYS-ASP-NH2(DISULFIDE BRIDGE:CYS1-CYS8)
- N-乙酰基-L-半胱氨酰-L-A-谷氨酰-L-组氨酰-3-(2-萘基)-D-丙氨酰-L-精氨酰-L-色氨酰甘氨酰-L-半胱氨酰-L-脯氨酰-L-脯氨酰-L-赖氨酰-L-A-天冬氨酰胺环(1->8)-二硫醚
- 207678-81-7
- Acetyl-(Cys??,D-2-Nal??,Cys??)-β-MSH (11-22) amide trifluoroacetate salt
- Acetyl-(Cys11,D-2-Nal1?,Cys1?)-β-MSH (11-22) amide trifluoroacetate salt
- Acetyl-(Cys11,D-2-Nal14,Cys18)-β-MSH (11-22) aMide HS014
- Acetyl-(Cys11,D-2-Nal14,Cys18)-β-MSH (11-22) amide
- L-α-Asparagine, N-acetyl-L-cysteinyl-L-α-glutamyl-L-histidyl-3-(2-naphthalenyl)-D-alanyl-L-arginyl-L-tryptophylglycyl-L-cysteinyl-L-prolyl-L-prolyl-L-lysyl-, cyclic (1→8)-disulfide
- (Ac-Cys11,D-Ala(2-naphthyl)14,Cys18)-b-MSH (11-22) amide
- mc4receptor antagonist
- [acetyl-cys11, β-(2-naphthyl)-d-ala14, cys18]-β-melanocyte stimulating hormone fragment 11-22
- (ACETYL-CYS11-BETA-(2-NAPHTHYL)*-D-ALA14,CYS18)-BET
- HS014
- MC4 Receptor antagonist, Melanocortin 4 Receptor antagonist
- Acetyl-(Cys11,D-2-Nal14,Cys18)-Beta-MSH (11-22) amide
- Melanocortin 4 Receptor antagonist
- Acetyl-(Cys11,D-2-Nal14,Cys18)-b-MSH (11-22) aMide
- Ac-Cys-Glu-His-D-Nal(2)-Arg-Trp-Gly-Cys-Pro-Pro-Lys-Asp-NH2 (Disulfide bridge Cys1-Cys8)
- Acetyl-(Cys11,D-2-Nal14,Cys18)-β-MSH (11-22) aMide
HS014
- M.W. 1563.77 C71H94N20O17S2
- [ACETYL-CYS11, B-(2-NAPHTHYL)-D-ALA14, CYS18]-BETA-MELANOCYTE STIMULATING HORMONE FRAGMENT 11-22
- (AC-CYS11,D-ALA(2-NAPHTHYL)14,CYS18)-BETA-MSH (11-22) AMIDE
- (AC-CYS11,D-2-NAL14,CYS18)-BETA-MSH (11-22) AMIDE
- AC-CYS-GLU-HIS-D-NAL(2)-ARG-TRP-GLY-CYS-PRO-PRO-LYS-ASP-NH2
- AC-CYS-GLU-HIS-D-2-NAL-ARG-TRP-GLY-CYS-PRO-PRO-LYS-ASP-NH2