4-硝基苯基4-(3-苯氧基苄基)哌嗪-1-甲酸叔丁酯
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- CAS号:
- 1210004-12-8
- 英文名:
- JZL 195
- 英文别名:
- CS-1586;JZL 195;JZL-195;JZL 195;JZL195;4-nitrophenyl 4-(3-phenoxybenzyl)piperazine-1-carboxylate;4-Nitrophenyl 4-[(3-phenoxyphenyl)methyl]-1-piperazinecarboxylate;4-[(3-Phenoxyphenyl)methyl]-1-piperazinecarboxylic acid 4-nitrophenyl ester;1-Piperazinecarboxylic acid, 4-[(3-phenoxyphenyl)methyl]-, 4-nitrophenyl ester;Autophagy,Monoacylglycerol lipase,inhibit,MAGL,Fatty acid amide hydrolase,JZL-195,JZL195,Inhibitor,FAAH,JZL 195
- 中文名:
- 4-硝基苯基4-(3-苯氧基苄基)哌嗪-1-甲酸叔丁酯
- 中文别名:
- 化合物JZL195;4-硝基苯基4-(3-苯氧基苄基)哌嗪-1-甲酸叔丁酯
- CBNumber:
- CB32591530
- 分子式:
- C24H23N3O5
- 分子量:
- 433.46
- MOL File:
- 1210004-12-8.mol
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4-硝基苯基4-(3-苯氧基苄基)哌嗪-1-甲酸叔丁酯化学性质
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沸点:
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581.8±50.0 °C(Predicted)
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密度:
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1.303±0.06 g/cm3(Predicted)
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储存条件:
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Sealed in dry,Store in freezer, under -20°C
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溶解度:
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DMSO: ≥5mg/mL at warmed
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酸度系数(pKa):
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6.13±0.10(Predicted)
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形态:
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powder
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颜色:
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white to beige
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4-硝基苯基4-(3-苯氧基苄基)哌嗪-1-甲酸叔丁酯性质、用途与生产工艺
JZL195是有效的FAAH和MAGL抑制剂，IC50分别为2 nM和4 nM。
| Target | Value |
FAAH
()
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2 nM
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MAGL
()
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4 nM
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JZL195 produces near-complete blockade of FP-Rh labeling of both mouse brain FAAH and MAGL at concentrations as low as 100 nM (IC
50
values of 13 and 19 nM, respectively).
JZL195 inhibits rat and human FAAH and MAGL enzymes with IC
50
values in the range of ≈10-100 nM based on competitive ABPP assays.
JZL195 (20 mg/kg; i.p.) produces an antinociceptive response in the tail immersion assay.
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Animal Model:
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Male C57BL/6J mice
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Dosage:
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20 mg/kg
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Administration:
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Intraperitoneal injection
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Result:
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Produced a much greater antinociceptive response in the tail immersion assay compared with inhibitors of either FAAH or MAGL alone.
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4-硝基苯基4-(3-苯氧基苄基)哌嗪-1-甲酸叔丁酯
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-15250 | 4-硝基苯基4-(3-苯氧基苄基)哌嗪-1-甲酸叔丁酯
JZL195 | 1210004-12-8 | 5mg | 500元 |
| 2024/04/30 | HY-15250 | JZL195 | | 10 mM * 1 mLin DMSO | 550元 |
4-硝基苯基4-(3-苯氧基苄基)哌嗪-1-甲酸叔丁酯
生产厂家
1210004-12-8, 4-硝基苯基4-(3-苯氧基苄基)哌嗪-1-甲酸叔丁酯 相关搜索:
- API
- Inhibitors
- 合成有机化合物配体
- 医药
- 小分子抑制剂，天然产物
- 小分子抑制剂
- 化合物JZL195
- 4-硝基苯基4-(3-苯氧基苄基)哌嗪-1-甲酸叔丁酯
- 1210004-12-8
- Autophagy,Monoacylglycerol lipase,inhibit,MAGL,Fatty acid amide hydrolase,JZL-195,JZL195,Inhibitor,FAAH,JZL 195
- 4-Nitrophenyl 4-[(3-phenoxyphenyl)methyl]-1-piperazinecarboxylate
- 1-Piperazinecarboxylic acid, 4-[(3-phenoxyphenyl)methyl]-, 4-nitrophenyl ester
- JZL-195;JZL 195;JZL195
- CS-1586
- 4-[(3-Phenoxyphenyl)methyl]-1-piperazinecarboxylic acid 4-nitrophenyl ester
- 4-nitrophenyl 4-(3-phenoxybenzyl)piperazine-1-carboxylate
- JZL 195