131359-24-5
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- CAS号:
- 131359-24-5
- 英文名:
- (E,E)-Bis(2-hydroxybenzylidene)acetone
(2-HBA)
- 英文别名:
- HBB2;2-HBA;abs820538;2-HBA Exclusive;bis(2-hydroxybenzylidene)acetone;(E,E)-Bis(2-hydroxybenzylidene)acetone;inhibit,2-HBA,Inhibitor,Caspase,2HBA,2 HBA;(E,E)-Bis(2-hydroxybenzylidene)acetone
(2-HBA);(E,E)-Bis(2-hydroxybenzylidene)acetone\n(2-HBA);(1E,4E)-1,5-Bis(2-hydroxyphenyl)penta-1,4-dien-3-one
- 中文名:
- 131359-24-5
- 中文别名:
- 2-HBA8;化合物2-HBA;(E,E)-二(2-羟基苄亚基)丙酮
- CBNumber:
- CB32653829
- 分子式:
- C17H14O3
- 分子量:
- 266.29
- MOL File:
- 131359-24-5.mol
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131359-24-5化学性质
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储存条件:
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Sealed in dry,Store in freezer, under -20°C
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溶解度:
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DMSO: soluble15mg/mL (clear solution)
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形态:
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powder
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颜色:
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white to beige
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InChIKey:
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YNVAHBUBGBLIEY-WGDLNXRISA-N
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131359-24-5性质、用途与生产工艺
2-HBA 是一个有效的 NAD(P)H: 醌受体氧化还原酶 1 (NQO1) 诱导剂，也可以激活半胱天冬酶-3 (caspase-3) 和半胱天冬酶-10 (caspase-10)。
When L1210 cells are exposed to 0.6 μM 2-HBA (bis(2-hydroxy-benzylidene)acetone), the specific activities of NQO1 and glutathione reductase increase by 6- and 1.5-fold, respectively. The total cellular glutathione content is also coordinately induced by 2.4-fold. In a more detailed study it is found that NQO1 is induced by 2-HBA in a concentration-dependent manner. Treatments with 2-HBA cause cell cycle arrest and apoptosis in both L1210 wild type cells and their Y8 drug-resistant counterparts in a concentration-dependent manner. 2-HBA can also activate caspase-3 and caspase-10.
131359-24-5
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-103667 | 131359-24-5
2-HBA | 131359-24-5 | 5mg | 600元 |
| 2024/04/30 | HY-103667 | 131359-24-5
2-HBA | 131359-24-5 | 10mg | 900元 |
131359-24-5, 131359-24-5 相关搜索:
- Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals
- Pharmaceuticals
- Intermediates & Fine Chemicals
- Aromatics
- 抑制剂
- 抑制剂
- 2-HBA8
- 化合物2-HBA
- (E,E)-二(2-羟基苄亚基)丙酮
- 131359-24-5
- inhibit,2-HBA,Inhibitor,Caspase,2HBA,2 HBA
- (1E,4E)-1,5-Bis(2-hydroxyphenyl)penta-1,4-dien-3-one
- abs820538
- (E,E)-Bis(2-hydroxybenzylidene)acetone
- 1,4-Pentadien-3-one, 1,5-bis(2-hydroxyphenyl)-, (1E,4E)-
- bis(2-hydroxybenzylidene)acetone
- 2-HBA Exclusive
- (E,E)-Bis(2-hydroxybenzylidene)acetone\n(2-HBA)
- 2-HBA
- HBB2
- (1E,4E)-1,5-Bis(2-Hydroxyphenyl)-1,4-pentadien-3-one
- (E,E)-Bis(2-hydroxybenzylidene)acetone
(2-HBA)