220355-63-5
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- CAS号:
- 220355-63-5
- 英文名:
- UKI-1
- 英文别名:
- UKI-1;UKI-1C;UKI 1,UKI1;Upamostat Impurity 4;1-Piperazinecarboxylic acid, 4-[(2S)-3-[3-(aminoiminomethyl)phenyl]-1-oxo-2-[[[2,4,6-tris(1-methylethyl)phenyl]sulfonyl]amino]propyl]-, ethyl ester
- 中文名:
- 220355-63-5
- 中文别名:
- 乌莫司他杂质4;化合物 T13251
- CBNumber:
- CB33133353
- 分子式:
- C32H47N5O5S
- 分子量:
- 613.81
- MOL File:
- 220355-63-5.mol
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220355-63-5化学性质
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沸点:
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745.5±70.0 °C(Predicted)
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密度:
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1.23±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO : ≥ 28 mg/mL (45.62 mM)
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酸度系数(pKa):
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9.76±0.50(Predicted)
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220355-63-5性质、用途与生产工艺
UKI-1 (UKI-1C) 是一种有效的尿激酶型纤溶酶原激活剂 (uPA) 抑制剂，Ki 为 0.41 μM。UKI-1 还是一种低分子量的丝氨酸蛋白酶 (serine protease) 抑制剂。UKI-1 是有效的抗转移剂，可抑制癌细胞的侵袭能力。
Ki: 0.41 μM (Urokinase-type plasminogen activator (uPA))
Serine protease
UKI-1 (WX-UK1; 0.1-1.0 μg/mL) treatment shows a decrease of tumor cell invasion by up to 50% is achieved in both models with the SCCHN line FaDu and the cervical carcinoma line HeLa.
UKI-1 (WX-UK1) interferes with the plasminogen activation system at 2 levels: it inhibits plasmin formation directly and via inhibition of uPA. In vitro invasion models with highly invasive fibrosarcoma and breast cancer cells showed that UKI-1 effectively inhibits migration of the cells through fibrin matrices.
UKI-1 (WX-UK1) treatment has antimetastatic activities that significantly reduces the number of metastatic lesions and tumor growth in metastasizing rat pancreatic and mammary adenocarcinoma tumor models.
220355-63-5
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上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-100415 | 220355-63-5
UKI-1 | 220355-63-5 | 1mg | 1500元 |
| 2024/04/30 | HY-100415 | 220355-63-5
UKI-1 | 220355-63-5 | 5mg | 3500元 |
220355-63-5, 220355-63-5 相关搜索:
- C32H47N5O5S
- 乌莫司他杂质4
- 化合物 T13251
- 220355-63-5
- Upamostat Impurity 4
- UKI 1,UKI1
- UKI-1C
- 1-Piperazinecarboxylic acid, 4-[(2S)-3-[3-(aminoiminomethyl)phenyl]-1-oxo-2-[[[2,4,6-tris(1-methylethyl)phenyl]sulfonyl]amino]propyl]-, ethyl ester
- UKI-1