化合物 T22720
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- CAS号:
- 15332-10-2
- 英文名:
- DFB
- 英文别名:
- DFB;3,3'-DIFLUOROBENZALDAZINE;3,3'-Difluorobenzaldazine;1,2-Bis(3-fluorobenzylidene)hydrazine;3,3' Difluorobenzaldazine,3,3'Difluorobenzaldazine;[(3-FLUOROPHENYL)METHYLENE]HYDRAZONE-3-FLUOROBENZALDEHYDE;Benzaldehyde, 3-fluoro-, 2-[(3-fluorophenyl)methylene]hydrazone;1-(3-fluorophenyl)-N-[(Z)-(3-fluorophenyl)methylideneamino]methanimine
- 中文名:
- 化合物 T22720
- 中文别名:
- 化合物 T22720;1,2-双(3-氟亚苄基)肼;DFB,MGLU5受体的正变构调节剂
- CBNumber:
- CB3322679
- 分子式:
- C14H10F2N2
- 分子量:
- 244.24
- MOL File:
- 15332-10-2.mol
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化合物 T22720化学性质
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沸点:
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326.6±42.0 °C(Predicted)
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密度:
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1.12±0.1 g/cm3(Predicted)
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储存条件:
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2-8°C
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溶解度:
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DMSO: ~12 mg/mL
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酸度系数(pKa):
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5.78±0.50(Predicted)
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形态:
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solid
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颜色:
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yellow
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化合物 T22720性质、用途与生产工艺
3,3'-Difluorobenzaldazine (DFB) 是一种选择性 mGluR5 正变构调节剂。3,3'-Difluorobenzaldazine 可增强 mGlu5 激动剂 (Glutamate, Quisqualate, 3,5-Dihydroxyphenylglycine) 的 3-6 倍作用，EC50 在 2 到 5 μM 范围内。
3,3'-Difluorobenzaldazine (DFB) causes a concentration-dependent potentiation of the response of human mGluR5 CHO cells to 300 nM glutamate in this assay. The maximal potentiation at this concentration of glutamate is approximately 3.1-fold, with an EC
50
for potentiation of 2.6 μM. 3,3'-Difluorobenzaldazine causes similar potentiation of the responses of both human mGluR5 and rat mGluR5 CHO cells to glutamate, quisqualate, and DHPG with comparable potencies.
3,3'-Difluorobenzaldazine (40-100 nmol; icv) attenuates the locomotor hyperactivity, motor incoordination, and cognitive impairment induced by Ketamine.
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Animal Model:
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Male NMRI and ICR mice (8-9 weeks, 33-40 g)
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Dosage:
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40-100 nmol (~9.7-24.4 μg)
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Administration:
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ICV
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Result:
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Attenuated the locomotor hyperactivity, motor incoordination, and cognitive impairment induced by Ketamine.
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化合物 T22720
上下游产品信息
上游原料
下游产品
15332-10-2, 化合物 T22720 相关搜索:
- Glutamate receptor
- 合成有机化合物配体
- C14H10F2N2
- DFB,MGLU5受体的正变构调节剂
- 1,2-双(3-氟亚苄基)肼
- 化合物 T22720
- 15332-10-2
- 3,3'-Difluorobenzaldazine
- 1,2-Bis(3-fluorobenzylidene)hydrazine
- 3,3' Difluorobenzaldazine,3,3'Difluorobenzaldazine
- Benzaldehyde, 3-fluoro-, 2-[(3-fluorophenyl)methylene]hydrazone
- 1-(3-fluorophenyl)-N-[(Z)-(3-fluorophenyl)methylideneamino]methanimine
- DFB
- 3,3'-DIFLUOROBENZALDAZINE
- [(3-FLUOROPHENYL)METHYLENE]HYDRAZONE-3-FLUOROBENZALDEHYDE