BRD4 INHIBITOR-10
|
|
|
- CAS号:
- 1660117-38-3
- 英文名:
- BRD4 Inhibitor-10
- 英文别名:
- BRD4 Inhibitor-10;BET BRD4 inhibitor compound II-25;BRD4 Inhibitor 10,BRD-4 Inhibitor-10,Inhibitor,BRD4 Inhibitor-10,Epigenetic Reader Domain,inhibit,BRD4 Inhibitor10;(S)-2,4-Dimethyl-6-(1-(1-phenylethyl)-6-(tetrahydro-2H-pyran-4-yl)-1H-imidazo[4,5-c]pyridin-2-yl)pyridazin-3(2H)-one;3(2H)-Pyridazinone, 2,4-dimethyl-6-[1-[(1S)-1-phenylethyl]-6-(tetrahydro-2H-pyran-4-yl)-1H-imidazo[4,5-c]pyridin-2-yl]-
- 中文名:
- BRD4 INHIBITOR-10
- 中文别名:
- 化合物BRD4 INHIBITOR-10;(S)-2,4-二甲基-6-(1-(1-苯乙基)-6-(四氢-2H-吡喃-4-基)-1H-咪唑并[4,5-C]吡啶-2-基)哒嗪-3(2H)-酮
- CBNumber:
- CB35821298
- 分子式:
- C25H27N5O2
- 分子量:
- 429.51
- MOL File:
- 1660117-38-3.mol
|
|
|
BRD4 INHIBITOR-10化学性质
-
沸点:
-
667.7±65.0 °C(Predicted)
-
|
-
密度:
-
1.30±0.1 g/cm3(Predicted)
-
|
-
储存条件:
-
Store at -20°C
-
|
-
溶解度:
-
DMSO : 125 mg/mL (291.03 mM; Need ultrasonic)
-
|
-
酸度系数(pKa):
-
3.37±0.50(Predicted)
-
|
BRD4 INHIBITOR-10性质、用途与生产工艺
BI 894999 是一种有效的、选择性的 BET 抑制剂，可抑制BRD4-BD1和BRD4-BD2与乙酰化组蛋白的结合，对应的IC50值分别为5 nM和41 nM。BI 894999 对BRD2/3/4和BRDT (Kd为0.49-1.6 nM) 具有高度选择性，相对于BRD4-BD1具有至少200倍的选择性。
| Target | Value |
BET
()
|
|
BRD4-BD1
(Cell-free assay)
|
5 nM
|
BRD4-BD2
(Cell-free assay)
|
41 nM
|
BRD4 INHIBITOR-10
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-117491 | BRD4 Inhibitor-10 | | 1 mg | 600元 |
| 2024/04/30 | HY-117491 | BRD4 INHIBITOR-10
BRD4 Inhibitor-10 | | 10 mM * 1 mLin DMSO | 1608元 |
1660117-38-3, BRD4 INHIBITOR-10 相关搜索:
- 药靶配体
- 抑制剂
- (S)-2,4-二甲基-6-(1-(1-苯乙基)-6-(四氢-2H-吡喃-4-基)-1H-咪唑并[4,5-C]吡啶-2-基)哒嗪-3(2H)-酮
- 化合物BRD4 INHIBITOR-10
- 1660117-38-3
- 3(2H)-Pyridazinone, 2,4-dimethyl-6-[1-[(1S)-1-phenylethyl]-6-(tetrahydro-2H-pyran-4-yl)-1H-imidazo[4,5-c]pyridin-2-yl]-
- BRD4 Inhibitor 10,BRD-4 Inhibitor-10,Inhibitor,BRD4 Inhibitor-10,Epigenetic Reader Domain,inhibit,BRD4 Inhibitor10
- (S)-2,4-Dimethyl-6-(1-(1-phenylethyl)-6-(tetrahydro-2H-pyran-4-yl)-1H-imidazo[4,5-c]pyridin-2-yl)pyridazin-3(2H)-one
- BET BRD4 inhibitor compound II-25
- BRD4 Inhibitor-10