7(R)-Maresin 1
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- CAS号:
- 1268720-28-0
- 英文名:
- 7(R)-Maresin 1
- 英文别名:
- Maresin 1;7(R)-Maresin 1;HLHYXXBCQOUTGK-FHCQLJOMSA-N;7(R)-Maresin 1 Exclusive;4,8,10,12,16,19-Docosahexaenoic acid, 7,14-dihydroxy-, (4Z,7R,8E,10E,12Z,14S,16Z,19Z)-
- 中文名:
- 7(R)-Maresin 1
- 中文别名:
- CBNumber:
- CB42590080
- 分子式:
- C22H32O4
- 分子量:
- 360.49
- MOL File:
- 1268720-28-0.mol
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7(R)-Maresin 1化学性质
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沸点:
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559.4±50.0 °C(Predicted)
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密度:
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1.048±0.06 g/cm3(Predicted)
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储存条件:
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Store at -80°C, protect from light
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溶解度:
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DMF: 50 mg/ml; DMSO: 50 mg/ml; Ethanol: 50 mg/ml; PBS (pH 7.2): 0.05 mg/ml
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酸度系数(pKa):
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4.58±0.10(Predicted)
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7(R)-Maresin 1性质、用途与生产工艺
Maresin 1 是人体内源性的 DHA 产生的 特异性调节介质，可以刺激胞内Ca2+ 产生和分泌。Maresin 1 具有抗炎活性。
Maresin 1 (MaR1, 300 nM) reduces neutrophil migration and reactive oxygen species production, besides decreasing IL-1b, TNF-a, IL-6, and INF-g production.
Cell Viability Assay
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Cell Line:
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Neutrophils (2 ╳10
5
cells/well).
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Concentration:
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300 nM.
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Incubation Time:
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30 min.
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Result:
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Adherent cells are stimulated for 24 h with LPS (1 mg/ml) in the presence or absence of MaR1 (300 nM) in a final volume of 250 ml/well
[3]
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Maresin 1 (MaR1) dose-dependently inhibits TRPV1 currents in neurons, blocks capsaicin (100 nM)-induced inward currents (IC
50
=0.49 nM), and reduces both inflammation- and chemotherapy-induced neuropathic pain in mice.
Maresin 1 (MaR1, 0.1, 0.3, and 1 μg/animal, e.v.) protects mice against acute DSS-induced colitis. Maresin 1 (0.3, and 1 μg/animal, e.v.) treatment markedly reduces macroscopic damage in the acute protocol of DSS-induced colitis.
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Animal Model:
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Male CD1 mice (8-10 wk of age) (colitis was induced by DSS).
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Dosage:
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0.1, 0.3, and 1 μg/animal.
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Administration:
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Intraocular route once a day from day 0 to day 7.
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Result:
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MaR1 (0.3 and 1 mg/animal) significantly reduces MPO levels in mouse colon tissue.
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7(R)-Maresin 1
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/04/30 | HY-116429 | Maresin 1 | | 10 μg (277.4 μM * 100 μL in Ethanol) | 2500元 |
| 2024/04/30 | HY-116429 | 7(R)-Maresin 1
Maresin 1 | 1268720-28-0 | 25μg(277.4μM * 250μL in Ethanol) | 5000元 |
1268720-28-0, 7(R)-Maresin 1 相关搜索:
- 生化试剂
- 1268720-28-0
- 4,8,10,12,16,19-Docosahexaenoic acid, 7,14-dihydroxy-, (4Z,7R,8E,10E,12Z,14S,16Z,19Z)-
- HLHYXXBCQOUTGK-FHCQLJOMSA-N
- 7(R)-Maresin 1 Exclusive
- Maresin 1
- 7(R)-Maresin 1