BD1063(盐酸盐)
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- CAS号:
- 206996-13-6
- 英文名:
- 1-[2-(3,4-Dichlorophenyl)ethyl]-4-Methylpiperazine Dihydrochloride
- 英文别名:
- BD1063 HCl;BD 1063 (hydrochloride);BD1063 (dhydrochloride);BD-1063 DHYDROCHLORIDE; BD 1063 DHYDROCHLORIDE;1-(3,4-Dichlorophenethyl)-4-methylpiperazine dihydrochloride;Sigma Receptor,Inhibitor,inhibit,BD1063 dhydrochloride,BD-1063 dhydrochloride
- 中文名:
- BD1063(盐酸盐)
- 中文别名:
- 化合物BD1063;BD1063二盐酸盐;BD1063(盐酸盐);1-(3,4-二氯苯乙基)-4-甲基哌嗪二盐酸盐;1-[2-(3,4-二氯苯基)乙基]-4-甲基哌嗪二盐酸盐
- CBNumber:
- CB42620871
- 分子式:
- C13H19Cl3N2
- 分子量:
- 309.66
- MOL File:
- 206996-13-6.mol
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BD1063(盐酸盐)化学性质
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储存条件:
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room temp
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溶解度:
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H2O: >15mg/mL
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形态:
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powder
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颜色:
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white to beige
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水溶解性:
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Soluble to 100 mM in water
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稳定性:
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Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 3 months.
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BD1063(盐酸盐)性质、用途与生产工艺
BD1063 2HCL (BD1063 dihydrochloride)是一种有效的选择性 sigma-1 receptor (σ1R) 拮抗剂，对应的Ki值为4.43 nM。
| Target | Value |
σ1R
(Cell-free assay)
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4.43 nM(Ki)
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BD1063 dose-dependently reduces ethanol self-administration in sP rats (3.3-11 mg/kg) and withdrawn, dependent Wistar rats (4-11 mg/kg) at doses that does not modify mean ethanol self-administration in non-dependent Wistar controls. BD1063 also reduces the breakpoints of sP rats to work for ethanol under a progressive-ratio reinforcement schedule. BD1063 dose-dependently reduces binge-like eating and the regularity of food responding, and blocks the increased eating rate in Palatable rats. In the light/dark conflict test, BD1063 antagonizes the increased time spent in the aversive compartment and the increased intake of the palatable diet, without affecting motor activity. The administration of BD1063 30 minutes before each paclitaxel dose prevents the development of cold and mechanical allodynia in WT mice. Moreover, the acute administration of BD1063 dose dependently reverses both types of paclitaxel-induced allodynia.
用途
The novel σ-receptor ligands
eurotransmitter antagonists.
BD1063(盐酸盐)
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下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-18101A | BD1063(盐酸盐)
BD1063 dhydrochloride | 206996-13-6 | 5mg | 770元 |
| 2024/04/30 | HY-18101A | BD1063(盐酸盐)
BD1063 dhydrochloride | 206996-13-6 | 10mM * 1mLin Water | 847元 |
206996-13-6, BD1063(盐酸盐) 相关搜索:
- Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals
- 天然产物
- 抑制剂
- 1-[2-(3,4-二氯苯基)乙基]-4-甲基哌嗪二盐酸盐
- BD1063二盐酸盐
- 化合物BD1063
- 1-(3,4-二氯苯乙基)-4-甲基哌嗪二盐酸盐
- BD1063(盐酸盐)
- 206996-13-6
- Sigma Receptor,Inhibitor,inhibit,BD1063 dhydrochloride,BD-1063 dhydrochloride
- 1-(3,4-Dichlorophenethyl)-4-methylpiperazine dihydrochloride
- BD1063 HCl
- BD-1063 DHYDROCHLORIDE; BD 1063 DHYDROCHLORIDE
- BD 1063 (hydrochloride)
- BD1063 (dhydrochloride)