173528-92-2
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- CAS号:
- 173528-92-2
- 英文名:
- (E)-4-[2-{2-[N-(4-Methoxybenzenesulfonyl)aMino]phenyl}ethenyl ]pyridine
- 英文别名:
- HMN-154;HMN 154;HMN154;inhibit,Inhibitor,HMN-154,HMN 154;2 AMINO 4 METHYL PYRIDINE AMINO PYRIDIN E;(E)-4-Methoxy-N-(2-(2-(pyridin-4-yl)vinyl)phenyl)benzenesulfonamide;(E)-4-[2-{2-[N-(4-Methoxybenzenesulfonyl)aMino]phenyl}ethenyl ]pyridine;Benzenesulfonamide, 4-methoxy-N-[2-[(1E)-2-(4-pyridinyl)ethenyl]phenyl]-
- 中文名:
- 173528-92-2
- 中文别名:
- 化合物HMN154;HMN-154游离态;(E)-4-甲氧基-N-(2-(2-(吡啶-4-基)乙烯基)苯基)苯磺酰胺
- CBNumber:
- CB42669159
- 分子式:
- C20H18N2O3S
- 分子量:
- 366.43
- MOL File:
- 173528-92-2.mol
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173528-92-2化学性质
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沸点:
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553.7±60.0 °C(Predicted)
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密度:
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1.313±0.06 g/cm3(Predicted)
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储存条件:
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Sealed in dry,Room Temperature
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溶解度:
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DMSO:15.0(Max Conc. mg/mL);40.93(Max Conc. mM)
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酸度系数(pKa):
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8.09±0.10(Predicted)
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173528-92-2性质、用途与生产工艺
HMN-154是一种新型的苯磺酰胺类抗癌化合物。HMN-154与NF-YB相互作用，从而中断NF-Y异源三聚体与DNA的结合。
IC50: 0.0026 μg/mL (KB cells), 0.003 μg/mL (colon38 cells)
HMN-154 interacts with NF-YB and thereby interrupts the binding of the NF-Y heterotrimer to DNA. NF-YB and thymosin β-10 are specific cellular binding proteins of HMN-154 and that this shared region is necessary for the binding to HMN-154. HMN-154 inhibits DNA binding of NF-Y to the human major histocompatibility complex class II human leukocyte antigen DRA Y-box sequence in a dose-dependent manner. HMN-154 shows very strong cytotoxicity against KB and colon38 cells with an IC
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value of 0.0026 and 0.003 μg/mL, respectively. HMN-154/BSA binds recombinant NF-YB or thymosin β-10 and the binding is inhibited by the addition of HMN-154 as the competitor. The binding between HMN-154 and NF-YB is specific and depends on its cytotoxicity.
173528-92-2
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下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2023/01/06 | S0288 | 173528-92-2
HMN-154 | 173528-92-2 | 5mg | 3824.73元 |
| 2023/01/06 | S0288 | 173528-92-2
HMN-154 | 173528-92-2 | 25mg | 11539.7元 |
173528-92-2, 173528-92-2 相关搜索:
- (E)-4-甲氧基-N-(2-(2-(吡啶-4-基)乙烯基)苯基)苯磺酰胺
- 化合物HMN154
- HMN-154游离态
- 173528-92-2
- inhibit,Inhibitor,HMN-154,HMN 154
- (E)-4-Methoxy-N-(2-(2-(pyridin-4-yl)vinyl)phenyl)benzenesulfonamide
- Benzenesulfonamide, 4-methoxy-N-[2-[(1E)-2-(4-pyridinyl)ethenyl]phenyl]-
- 2 AMINO 4 METHYL PYRIDINE AMINO PYRIDIN E
- HMN-154;HMN 154;HMN154
- (E)-4-[2-{2-[N-(4-Methoxybenzenesulfonyl)aMino]phenyl}ethenyl ]pyridine