NF449
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- CAS号:
- 627034-85-9
- 英文名:
- NF449
- 英文别名:
- NF449 octasodium;NF449 Sodium Salt
- 中文名:
- NF449
- 中文别名:
- CBNumber:
- CB42696122
- 分子式:
- C41H32N6O29S8
- 分子量:
- 1329.23558
- MOL File:
- 627034-85-9.mol
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NF449化学性质
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in H2O
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形态:
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crystalline solid
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水溶解性:
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Soluble to 50 mM in water with gentle warming
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稳定性:
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Hygroscopic
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NF449性质、用途与生产工艺
NF449 octasodium 是一种高效的 P2X1 受体拮抗剂，对 rP2X1、rP2X1+5、P2X2+3 的 IC50 分别为 0.28、0.69 和 120 nM。NF449 octasodium 是一种 Gsα 选择性 G 蛋白 (G Protein) 拮抗剂。NF449 octasodium 抑制 GTP[γS] 与 Gsα-s 结合的速率，抑制腺苷酸环化酶活性的刺激，阻断 β-肾上腺素能受体与 Gs 的偶联。
NF449 suppressed the rate of GTP[γS] binding to rG
sα-s
while barely affecting binding to rG
iα-1
(IC
50
=140 nM), inhibits stimulation of adenylyl cyclase activity in S49 cyc− membranes (deficient in endogenous Gsα) by exogenously added Gsα-s, and blocks the coupling of β-adrenergic receptors to G
s
(EC
50
=7.9 μM).
At a dose of 10 mg/kg, NF449 inhibits the ex vivo aggregation triggered by 5 g/ml collagen in WT mouse platelets without affecting that induced by 5 μM ADP. At a higher dose (50 mg/kg), NF449 inhibits ex vivo platelet aggregation in response to not only 10 g/ml collagen but also 5 M ADP, indicating nonselective inhibition of the P2Y1 and/or P2Y12 receptor.
NF449
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| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-112461A | NF449 octasodium | | 5 mg | 2150元 |
| 2024/04/30 | HY-112461A | NF449 octasodium | | 10 mg | 3400元 |
627034-85-9, NF449 相关搜索:
- Amines, Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals, Sulfur & Selenium Compounds
- 627034-85-9
- NF449 octasodium
- NF449 Sodium Salt