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2-METHYL-8-(PHENYLMETHOXY)IMIDAZO[1,2-A]PYRIDINE-3-ACETONITRILE
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- CAS号:
- 76081-98-6
- 英文名:
- 2-METHYL-8-(PHENYLMETHOXY)IMIDAZO[1,2-A]PYRIDINE-3-ACETONITRILE
- 英文别名:
- S28080;SCH 28080;SCH-28080,SCH28080;Schering compound 28080;imidazo-(1-2-a)pyrine-3-acetonitrile;2-Methyl-8-(phenylmethoxy)imidazo-(1-2-A)pyrine-3-acetonitrile;2-METHYL-8-(PHENYLMETHOXY)IMIDAZO[1,2-A]PYRIDINE-3-ACETONITRILE;Imidazo(1,2-A)pyridine-3-acetonitrile, 2-methyl-8-(phenylmethoxy)-;3-(CYANOMETHYL)-2-METHYL-8-(PHENYLMETHOXY)IMIDAZO[1,2-ALPHA]PYRIDINE
- 中文名:
- 2-METHYL-8-(PHENYLMETHOXY)IMIDAZO[1,2-A]PYRIDINE-3-ACETONITRILE
- 中文别名:
- 化合物 T16865;SCH 28080,H +,K + -ATPASE抑制剂
- CBNumber:
- CB4281209
- 分子式:
- C17H15N3O
- 分子量:
- 277.32
- MOL File:
- 76081-98-6.mol
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2-METHYL-8-(PHENYLMETHOXY)IMIDAZO[1,2-A]PYRIDINE-3-ACETONITRILE化学性质
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密度:
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1.16±0.1 g/cm3(Predicted)
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储存条件:
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-20°C
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溶解度:
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DMSO: >10 mg/mL, soluble
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形态:
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solid
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酸度系数(pKa):
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5.85±0.10(Predicted)
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颜色:
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white to light tan
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2-METHYL-8-(PHENYLMETHOXY)IMIDAZO[1,2-A]PYRIDINE-3-ACETONITRILE性质、用途与生产工艺
SCH28080 是一种可逆的，K+ 竞争性的胃 H,K-ATPase 抑制剂，Ki 值 为 0.12 μM。SCH28080 在体内是有效的酸分泌抑制剂，具有抗溃疡作用。
Ki: 0.12 μM ((H
+
/K
+
)-ATPase)
SCH28080 competitively inhibits the K
+
-stimulated hydrolysis of ATP, with a K
i
of 0.12 μM .
SCH28080 inhibits histamine-induced
[14C]
aminopyrine uptake into isolated rabbit parietal cells with an IC
50
of 0.029 μM.
SCH28080 causes a dose-dependent reduction in cell viability with IC
50
values of 22.9 µM and 15.3 µM after 2 h and 24 h treatments, respectively, and cell viability was below 10% at 100 µM already after 2 h treatment.
SCH28080 induces apoptosis and is cytotoxic at higher doses.
SCH28080 inhibits insulin secretion by activation of IK ATP and inhibition of L-type voltage-gated Ca
2+
channels, reduces cell viability and dose-dependently induces apoptosis/necrosis.
Cell Viability Assay
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Cell Line:
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INS-1E cell
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Concentration:
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3.1 μM, 6.25 μM, 12.5 μM, 25 μM, 50 μM, 100 μM
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Incubation Time:
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2 hours, 24 hours
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Result:
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Caused a dose-dependent reduction in cell viability.
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SCH28080 (20 mg/kg; i.p.) inhibits gastric ulcers induced by pylorusligation in rats.
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Animal Model:
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Male Wistar rat (280-350 g), the Shay rat model
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Dosage:
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20 mg/kg
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Administration:
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Intraperitoneal injection
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Result:
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Showed 91% inhibition on gastric ulcers induced by pylorusligation in rats.
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2-METHYL-8-(PHENYLMETHOXY)IMIDAZO[1,2-A]PYRIDINE-3-ACETONITRILE
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-103261 | 2-METHYL-8-(PHENYLMETHOXY)IMIDAZO[1,2-A]PYRIDINE-3-ACETONITRILE
SCH28080 | 76081-98-6 | 1mg | 400元 |
| 2024/04/30 | HY-103261 | SCH28080 | | 5 mg | 1100元 |
2-METHYL-8-(PHENYLMETHOXY)IMIDAZO[1,2-A]PYRIDINE-3-ACETONITRILE
生产厂家
76081-98-6, 2-METHYL-8-(PHENYLMETHOXY)IMIDAZO[1,2-A]PYRIDINE-3-ACETONITRILE 相关搜索:
- ATPase
- 酶
- Cell Biology
- Cell Signaling and Neuroscience
- BioChemical
- Voltage-gated Ion Channels
- Monovalent Ion Channels
- Ion Channels
- Ion Pump Inhibitors
- SCH 28080,H +,K + -ATPASE抑制剂
- 化合物 T16865
- 76081-98-6
- SCH-28080,SCH28080
- imidazo-(1-2-a)pyrine-3-acetonitrile
- SCH 28080
- Schering compound 28080
- S28080
- Imidazo(1,2-A)pyridine-3-acetonitrile, 2-methyl-8-(phenylmethoxy)-
- 2-Methyl-8-(phenylmethoxy)imidazo-(1-2-A)pyrine-3-acetonitrile
- 2-METHYL-8-(PHENYLMETHOXY)IMIDAZO[1,2-A]PYRIDINE-3-ACETONITRILE
- 3-(CYANOMETHYL)-2-METHYL-8-(PHENYLMETHOXY)IMIDAZO[1,2-ALPHA]PYRIDINE