DYNORPHIN A (1-10)
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- CAS号:
- 79994-24-4
- 英文名:
- H-TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-PRO-OH
- 英文别名:
- YGGFLRRIRP;DYNORPHIN A (1-10);Porcine dynorphin A(1-10);DYNORPHIN A (1-10), PORCINE;dynorphin A, porcine, fragment 1-10;TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-PRO;dynorphin A fragment 1-10 porcine*sequence;H-TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-PRO-OH;DYNORPHIN A (1-10) SYNTHETIC >97% OPIOID AGONIST
- 中文名:
- DYNORPHIN A (1-10)
- 中文别名:
- 强啡肽A(1-10);强啡肽A(1-10)、 DYNORPHIN A (1-10);DYNORPHIN A (1-10), PORCINE,YGGFLRRIRP
- CBNumber:
- CB4395153
- 分子式:
- C57H91N19O12
- 分子量:
- 1234.45
- MOL File:
- 79994-24-4.mol
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DYNORPHIN A (1-10)化学性质
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储存条件:
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-15°C
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溶解度:
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Soluble in DMSO
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DYNORPHIN A (1-10)性质、用途与生产工艺
Dynorphin A (1-10) 是一种内源性的阿片样神经肽，与 κ 阿片受体 (κ-opioid receptor) 结合。Dynorphin A (1-10) 也阻断 NMDA 激活的电流，IC50 为 42.0 μM。
κ-opioid receptor
NMDA receptor
Dynorphin A (1-10) binds in the transmembrane domain of the κ-receptor. The non-opioid actions of various forms of Dynorphin A (DynA) are examined on N-methyl-D-aspartate (NMDA) receptor channels in isolated rat trigeminal neurons using the whole-cell patch recording technique. All the dynorphins tested blocked NMDA-activated currents. The blocking actions are voltage-independent. The IC
50
is 42.0 μM for DynA(1-10). To determine if shorter dynorphins have the similar blocking property, we examined the action of DynA(1-10) at different membrane potentials. DynA(1-10) blocks I
NMDA
to a similar extent as the membrane potentials changed from -80 to +60 mV. Thus, despite a 160-fold difference in the apparent affinities, DynA(1-32) and DynA(1-10) both exert voltage-independent actions on NMDA receptors.
DYNORPHIN A (1-10)
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79994-24-4, DYNORPHIN A (1-10) 相关搜索:
- peptide
- 目录肽
- 多肽
- C57H92N20O11
- C57H91N19O12
- 强啡肽A(1-10)、 DYNORPHIN A (1-10)
- DYNORPHIN A (1-10), PORCINE,YGGFLRRIRP
- 强啡肽A(1-10)
- 79994-24-4
- Porcine dynorphin A(1-10)
- YGGFLRRIRP
- TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-PRO
- dynorphin A, porcine, fragment 1-10
- H-TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-PRO-OH
- DYNORPHIN A (1-10)
- DYNORPHIN A (1-10), PORCINE
- dynorphin A fragment 1-10 porcine*sequence
- DYNORPHIN A (1-10) SYNTHETIC >97% OPIOID AGONIST