雷弗霉素 A
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- CAS号:
- 134615-37-5
- 英文名:
- REVEROMYCIN A
- 英文别名:
- REVEROMYCIN A;ZESGNAJSBDILTB-OXVOKJAASA-N;Butanedioic acid, 1-[(2S,3R,6S,8R,9S)-3-butyl-8-[(2E,4E,6S,7S,8E)-9-carboxy-6-hydroxy-3,7-dimethyl-2,4,8-nonatrien-1-yl]-2-[(1E,3E)-4-carboxy-3-methyl-1,3-butadien-1-yl]-9-methyl-1,7-dioxaspiro[5.5]undec-3-yl] ester
- 中文名:
- 雷弗霉素 A
- 中文别名:
- 雷弗霉素 A;雷弗霉素A REVEROMYCIN A
- CBNumber:
- CB4443481
- 分子式:
- C36H52O11
- 分子量:
- 660.79
- MOL File:
- 134615-37-5.mol
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雷弗霉素 A化学性质
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沸点:
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849.0±65.0 °C(Predicted)
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密度:
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1.21±0.1 g/cm3(Predicted)
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储存条件:
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−20°C
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溶解度:
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DMF: soluble
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形态:
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solid
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酸度系数(pKa):
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4.36±0.17(Predicted)
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颜色:
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tan
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雷弗霉素 A性质、用途与生产工艺
Reveromycin A 是一种从链霉菌属中分离出来的苯甲醌类抗生素 (antibiotic)，是选择性的真核细胞中蛋白质合成 (protein synthesis) 抑制剂。Reveromycin A 通过诱导破骨细胞的凋亡 (apoptosis) 来抑制骨吸收。Reveromycin A 对肿瘤细胞系具有抗增殖活性，并具有抗真菌 (antifungal) 活性。
Reveromycin A inhibits protein synthesis in osteoclasts (OCs) by selectively blocking enzymatic activity of isoleucyl-tRNA synthetase.
Reveromycin A (0.3-30 μM; for 24 h) induces apoptosis in OCs through inhibition of protein synthesis.
Reveromycin A (20 mg/kg; twice daily; i.v.; for 3 days) significantly decreases numbers of OCs without affecting numbers of osteoblasts in normal 4-week-old male Sprague-Dawley rats.
雷弗霉素 A
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| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-129337 | 雷弗霉素 A
Reveromycin A | 134615-37-5 | 1 mg | 18200元 |
134615-37-5, 雷弗霉素 A 相关搜索:
- Antineoplastic and Immunosuppressive AntibioticsReceptor Tyrosine Kinase Biology
- Spectrum of Activity
- Receptor Tyrosine Kinase Inhibitors
- Mechanism of Action
- AntifungalAntibiotics
- Antibiotics N-SAntibiotics
- Antibiotics by Application
- Antibiotics A to
- Antibiotics
- Interferes with Protein Synthesis
- Epidermal Growth Factor Receptor (EGFR)Antibiotics
- 微生物代谢物
- Antibiotics N-S
- Antibiotics A to Z
- Antibiotics
- BioChemical
- C36H52O11
- 雷弗霉素A REVEROMYCIN A
- 雷弗霉素 A
- 134615-37-5
- Butanedioic acid, 1-[(2S,3R,6S,8R,9S)-3-butyl-8-[(2E,4E,6S,7S,8E)-9-carboxy-6-hydroxy-3,7-dimethyl-2,4,8-nonatrien-1-yl]-2-[(1E,3E)-4-carboxy-3-methyl-1,3-butadien-1-yl]-9-methyl-1,7-dioxaspiro[5.5]undec-3-yl] ester
- ZESGNAJSBDILTB-OXVOKJAASA-N
- REVEROMYCIN A