化合物AS1810722
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- CAS号:
- 909561-15-5
- 英文名:
- 1-Piperazineacetamide, 4-[4-[[7-[(3,5-difluorophenyl)methyl]-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]phenyl]-
- 英文别名:
- AS1810722;1-Piperazineacetamide, 4-[4-[[7-[(3,5-difluorophenyl)methyl]-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]phenyl]-;AS-1810722,inhibit,CYPs,AS 1810722,Cytochrome P450,eosinophil,allergic,AS1810722,STAT,orally,Inhibitor,asthma,IL-4,infiltration,IFN-γ
- 中文名:
- 化合物AS1810722
- 中文别名:
- 化合物AS1810722;4-[4-[[7-[(3,5-二氟苯基)甲基]-7H-吡咯并[2,3-D]嘧啶-2-基]氨基]苯基]-1-哌嗪乙酰胺
- CBNumber:
- CB48650663
- 分子式:
- C25H25F2N7O
- 分子量:
- 477.51
- MOL File:
- 909561-15-5.mol
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化合物AS1810722化学性质
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沸点:
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731.4±70.0 °C(Predicted)
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密度:
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1.41±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO: 62.5 mg/mL (130.89 mM)
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酸度系数(pKa):
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16.30±0.40(Predicted)
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化合物AS1810722性质、用途与生产工艺
AS1810722 是口服有效的 STAT6 抑制剂，IC50 为 1.9 nM。AS1810722 显示出良好的 CYP3A4 抑制作用。AS1810722 具有用于过敏性疾病，例如哮喘和特应性疾病研究的潜力。
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STAT6
1.9 nM (IC
50
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CYP3A4
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AS1810722 (compound 24) inhibits production of IL-4 with an IC
50
of 2.4 nM, but shows no effect on production of IFN-γ.
AS1810722 (compound 24) suppress eosinophil infiltration in the lung in a dose-dependent manner in an antigen-induced mouse asthmatic model.
AS1810722 inhibits in vitro Th2 differentiation with an IC
50
of 2.4 nM without affecting type 1 helper T (Th1) cell differentiation and eosinophil infiltration in an antigen-induced mouse asthmatic model after oral administration.
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Animal Model:
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Female Balb/c mice asthmatic model by intraperitoneal injection of OVA-containing aluminum hydroxide gel
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Dosage:
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0.03-0.3 mg/kg
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Administration:
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Orally; 30 min before, and 24 and 48 h after OVA exposure
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Result:
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Suppressed eosinophil infiltration in the lung in a dose-dependent manner.
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化合物AS1810722
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下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/04/30 | HY-134772 | 化合物AS1810722
AS1810722 | 909561-15-5 | 5mg | 3000元 |
| 2024/04/30 | HY-134772 | 化合物AS1810722
AS1810722 | 909561-15-5 | 10mM * 1mLin DMSO | 3152元 |
909561-15-5, 化合物AS1810722 相关搜索:
- C25H25F2N7O
- 4-[4-[[7-[(3,5-二氟苯基)甲基]-7H-吡咯并[2,3-D]嘧啶-2-基]氨基]苯基]-1-哌嗪乙酰胺
- 化合物AS1810722
- 909561-15-5
- AS-1810722,inhibit,CYPs,AS 1810722,Cytochrome P450,eosinophil,allergic,AS1810722,STAT,orally,Inhibitor,asthma,IL-4,infiltration,IFN-γ
- AS1810722
- 1-Piperazineacetamide, 4-[4-[[7-[(3,5-difluorophenyl)methyl]-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]phenyl]-