网站主页 >> CAS数据库列表 >> 4,4'-(dithiodicarbonothioyl)dimorpholine
4,4'-(dithiodicarbonothioyl)dimorpholine
|
|
|
- CAS号:
- 729-46-4
- 英文名:
- 4,4'-(dithiodicarbonothioyl)dimorpholine
- 英文别名:
- JX 06;Bis(morpholinothiocarbonyl) disulfide;Bis(morpholinocarbonothioyl) persulfide;4,4'-(dithiodicarbonothioyl)dimorpholine;4,4'-(dithiodicarbonothioyl)dimorpholine;Morpholine, 4,4-(dithiodicarbonothioyl)bis-;Apoptosis,JX06,JX-06,Inhibitor,PDH kinase,inhibit,Pyruvate dehydrogenase kinase,JX 06,PDHK
- 中文名:
- 4,4'-(dithiodicarbonothioyl)dimorpholine
- 中文别名:
- 化合物JX06;双(吗啉硫代羰基)二硫化物;双(吗啉噻吩羰基)二硫化物;双(吗啉代硫代羰基)二硫化物(JX 06)
- CBNumber:
- CB4875824
- 分子式:
- C10H16N2O2S4
- 分子量:
- 324.51
- MOL File:
- 729-46-4.mol
|
|
|
4,4'-(dithiodicarbonothioyl)dimorpholine化学性质
4,4'-(dithiodicarbonothioyl)dimorpholine性质、用途与生产工艺
JX06 是一种细胞中的 PDK1 的选择性共价抑制剂。JX06 可剂量依赖性地抑制PDK1、PDK2和PDK3，对应的IC50值分别为0.049 μM、0.101 μM 和 0.313 μM。
| Target | Value |
PDK1
(Cell-free assay)
|
0.049 μM
|
PDK2
(Cell-free assay)
|
0.101 μM
|
PDK3
(Cell-free assay)
|
0.313 μM
|
JX06 barely shows inhibitory activity against PDK4 at a concentration of 10 μM.
JX06 (1-10 μM; 48 hours) induces cell apoptosis in cancer cells with high ECAR/OCR.
JX06 (0-0.6 μM; 72 hours) dose-dependently suppresses the growth of A549 cells.
JX06 (0.1-10 μM; 6-24 hours) inhibits PDHA1 phosphorylation in A549 cells in a time- and dose-dependent manner.
JX06 (1-10 μM) increases glucose uptake and intracellular ATP level and reduces aerobic glycolysis determined by the lactate production in A549 cells.
JX06 (1-10 μM; 24 hours) induces ROS generation in cancer cells with high extracellular acidification rate (ECAR)/ oxygen consumption rate (OCR) .
Apoptosis Analysis
|
Cell Line:
|
A549, EBC-1, HT-29 and H460 cells
|
|
Concentration:
|
0, 1, 3, 10 μM
|
|
Incubation Time:
|
48 hours
|
|
Result:
|
Induces cell apoptosis in A549 and EBC-1 cells.
|
Cell Viability Assay
|
Cell Line:
|
A549 cells
|
|
Concentration:
|
0, 0.2, 0.4, 0.6 μM
|
|
Incubation Time:
|
72 hours
|
|
Result:
|
Inhibits the viability of A549 cells in a dose dependent manner.
|
Western Blot Analysis
|
Cell Line:
|
A549 cells
|
|
Concentration:
|
0, 0.1, 0.3, 1, 3, 10 μM
|
|
Incubation Time:
|
0, 6, 12, 24 hours
|
|
Result:
|
Decreased PDHA1 phosphorylation at both serine 293 and serine 232 (S293 and S232) in a time- and dose-dependent manner.
|
JX06 (40-80 mg/kg; i.p. for 21 days) inhibits tumor growth in vivo.
|
Animal Model:
|
A549 subcutaneous xenograft mice
|
|
Dosage:
|
40, 80 mg/kg
|
|
Administration:
|
I.p. injections for 21 days
|
|
Result:
|
Reduced tumor weights and 67.5% tumor volume at the dose of 80 mg/kg compared with the vehicle control.
Well tolerated at the administration dose.
|
4,4'-(dithiodicarbonothioyl)dimorpholine
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-19564 | 4,4'-(dithiodicarbonothioyl)dimorpholine
JX06 | 729-46-4 | 5mg | 500元 |
| 2024/04/30 | HY-19564 | 4,4'-(dithiodicarbonothioyl)dimorpholine
JX06 | 729-46-4 | 10mM * 1mLin DMSO | 550元 |
4,4'-(dithiodicarbonothioyl)dimorpholine
生产厂家
729-46-4, 4,4'-(dithiodicarbonothioyl)dimorpholine 相关搜索:
- 药靶配体
- 抑制剂
- C10H16N2O2S4
- 双(吗啉噻吩羰基)二硫化物
- 双(吗啉代硫代羰基)二硫化物(JX 06)
- 双(吗啉硫代羰基)二硫化物
- 化合物JX06
- 729-46-4
- 4,4'-(dithiodicarbonothioyl)dimorpholine
- Apoptosis,JX06,JX-06,Inhibitor,PDH kinase,inhibit,Pyruvate dehydrogenase kinase,JX 06,PDHK
- Bis(morpholinothiocarbonyl) disulfide
- JX 06
- Bis(morpholinocarbonothioyl) persulfide
- Morpholine, 4,4-(dithiodicarbonothioyl)bis-
- 4,4'-(dithiodicarbonothioyl)dimorpholine