化合物SB 204990
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- CAS号:
- 154566-12-8
- 英文名:
- SB 204990
- 英文别名:
- SB 204990;SB-204990(racemic);YTRNLFYTHYWDAU-KDOFPFPSSA-N;SB204990,Inhibitor,inhibit,ACLY,SB 204990,ATP Citrate Lyase,SB-204990;(3R,5S)-rel-5-[6-(2,4-Dichlorophenyl)hexyl]tetrahydro-3-hydroxy-2-oxo-3-furanacetic acid;2-((3R,5S)-5-(6-(2,4-dichlorophenyl)hexyl)-3-hydroxy-2-oxotetrahydrofuran-3-yl)acetic acid;3-Furanacetic acid, 5-[6-(2,4-dichlorophenyl)hexyl]tetrahydro-3-hydroxy-2-oxo-, (3R,5S)-rel-
- 中文名:
- 化合物SB 204990
- 中文别名:
- 化合物SB 204990;SB-204990(消旋);SB 204990,ATP柠檬酸裂解酶(ACLY)抑制剂
- CBNumber:
- CB51363884
- 分子式:
- C18H22Cl2O5
- 分子量:
- 389.27
- MOL File:
- 154566-12-8.mol
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化合物SB 204990化学性质
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熔点:
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87-89 °C
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沸点:
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571.6±40.0 °C(Predicted)
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密度:
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1.332±0.06 g/cm3(Predicted)
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溶解度:
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DMF: 30 mg/ml; DMF:PBS(pH7.2) (1:2): 0.33 mg/ml; DMSO: 20 mg/ml; Ethanol: 1 mg/ml
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形态:
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A crystalline solid
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酸度系数(pKa):
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4.33±0.10(Predicted)
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InChI:
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InChI=1/C18H22Cl2O5/c19-13-8-7-12(15(20)9-13)5-3-1-2-4-6-14-10-18(24,11-16(21)22)17(23)25-14/h7-9,14,24H,1-6,10-11H2,(H,21,22)/t14-,18+/s3
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InChIKey:
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YTRNLFYTHYWDAU-RVFWCEGZNA-N
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SMILES:
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O1[C@@H](CCCCCCC2=CC=C(Cl)C=C2Cl)C[C@@](O)(CC(O)=O)C1=O |&1:1,17,r|
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化合物SB 204990性质、用途与生产工艺
SB 204990是ATP柠檬酸裂解酶 (ACLY) 的有效特异性抑制剂。
SB204990 (SB) is a specific inhibitor of ACLY enzyme. SB204990 treatment leads to a decrease in cytosolic Ac-CoA level and is thus expected to decrease acetylated and active β-catenin levels.
SB 204990, when administered orally to rats, is absorbed into the systemic circulation. When administered in the diet (0.05-0.25%, w/w) for 1 week, SB 204990 causes a dose-related decrease in plasma cholesterol (by up to 46%) and triglyceride levels (by up to 80%) in rats. SB 204990 (25 mg/kg per day) also decreases plasma cholesterol levels (by up to 23%) and triglyceride levels (by up to 38%) in the dog, preferentially decreasing low-density lipoprotein compared with high-density lipoprotein cholesterol levels.
化合物SB 204990
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/04/30 | HY-16450 | 化合物SB 204990 SB 204990 | 154566-12-8 | 10mM * 1mLin DMSO | 1320元 |
2024/04/30 | HY-16450 | 化合物SB 204990 SB 204990 | 154566-12-8 | 10mg | 2040元 |
154566-12-8, 化合物SB 204990 相关搜索:
- 酶
- 化学试剂
- C18H22Cl2O5
- SB 204990,ATP柠檬酸裂解酶(ACLY)抑制剂
- SB-204990(消旋)
- 化合物SB 204990
- 154566-12-8
- SB204990,Inhibitor,inhibit,ACLY,SB 204990,ATP Citrate Lyase,SB-204990
- SB-204990(racemic)
- YTRNLFYTHYWDAU-KDOFPFPSSA-N
- (3R,5S)-rel-5-[6-(2,4-Dichlorophenyl)hexyl]tetrahydro-3-hydroxy-2-oxo-3-furanacetic acid
- 2-((3R,5S)-5-(6-(2,4-dichlorophenyl)hexyl)-3-hydroxy-2-oxotetrahydrofuran-3-yl)acetic acid
- 3-Furanacetic acid, 5-[6-(2,4-dichlorophenyl)hexyl]tetrahydro-3-hydroxy-2-oxo-, (3R,5S)-rel-
- SB 204990