aspergillimide
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- CAS号:
- 195966-93-9
- 英文名:
- aspergillimide
- 英文别名:
- aspergillimide;(rel)-Asperparaline A;Spiro[5H,6H-5a,9a-(iminomethano)-1H-cyclopent[f]indolizine-7(8H),3'-pyrrolidine]-2',5',10-trione, tetrahydro-1,1',8,8,11-pentamethyl-, (1R,3'R,5aR,8aR,9aS)-rel-(-)-
- 中文名:
- aspergillimide
- 中文别名:
- 曲霉酰亚胺
- CBNumber:
- CB51371818
- 分子式:
- C20H29N3O3
- 分子量:
- 359.46256
- MOL File:
- 195966-93-9.mol
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aspergillimide化学性质
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沸点:
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546.1±50.0 °C(Predicted)
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密度:
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1.30±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO: soluble; Ethanol: soluble; Methanol: soluble
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形态:
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A solid
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酸度系数(pKa):
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8.68±0.60(Predicted)
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颜色:
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White
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aspergillimide性质、用途与生产工艺
(rel)-Asperparaline A ((rel)-Aspergillimide)，是一种从 Aspergillus japonicas JV-23 发酵的豆渣中分离得到的驱虫代谢产物。(rel)-Asperparaline A 也是一种有效和选择性的 nAChR 拮抗剂。(rel)-Asperparaline A 在蚕中表现出麻痹作用。
Asperparaline A (1 μM; 1 min) markedly and reversibly blocks the acetylcholine (Ach; 10 µM)-induced current in the silkworm larval neurons.
Asperparaline A (1-1000 nM; 1 min) differentially blocks the peak and slowly desensitizing currents, with IC
50
s of 20.2 and 39.6 nM, respectively.
Asperparaline A (10 μM; 1 min) reduces the peak current amplitude of the ACh (100 µM)-induced response of α3β4 nAChR by 33.4%, while barely influencing the amplitudes of the responses to ACh of the α4β2 and α7 nAChRs in
X. laevis
oocytes.
Asperparaline A (10 μg/g; p.o.) exhibits paralysis against silk worms within 1 h and lasts for 7 to 10 h.
Asperparaline A (3 μg/g; injection with a micro-syringe) exhibits paralysis activity against silk worms within 20 min and lasts for 4 to 5 h.
aspergillimide
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| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-124874 | 曲霉酰亚胺
(rel)-Asperparaline A | 195966-93-9 | 5mg | 8748元 |
195966-93-9, aspergillimide 相关搜索:
- 曲霉酰亚胺
- 195966-93-9
- (rel)-Asperparaline A
- Spiro[5H,6H-5a,9a-(iminomethano)-1H-cyclopent[f]indolizine-7(8H),3'-pyrrolidine]-2',5',10-trione, tetrahydro-1,1',8,8,11-pentamethyl-, (1R,3'R,5aR,8aR,9aS)-rel-(-)-
- aspergillimide