CVT 313
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- CAS号:
- 199986-75-9
- 英文名:
- 2(BIS-(HYDROXYETHYL)AMINO)-6-(4-METHOXYBENZYLAMINO)-9-ISOPROPYL-PURINE
- 英文别名:
- BAT5;NG 26;D6S82E;CVT-313;CS-2441;CVT-313, >98%;CVT-313(NG-26);CDK2 INHIBITOR III;CVT 313;NG 26;CVT313;NG26;CVT-313 (CDK2 INHIBITOR III)
- 中文名:
- CVT 313
- 中文别名:
- 化合物CVT313;CVT-313游离态;CVT-313,CDK2抑制剂;CDK2抑制剂(CVT-313);2,2'-((9-异丙基-6-((4-甲氧基苄基)氨基)-9H-嘌呤-2-基)氮烷二基)二乙醇;2,2'-((9-异丙基-6-((4-甲氧基苄基)氨基)-9H-嘌呤-2-基)氮烷二基)二乙醇
- CBNumber:
- CB5143133
- 分子式:
- C20H28N6O3
- 分子量:
- 400.47
- MOL File:
- 199986-75-9.mol
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CVT 313化学性质
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沸点:
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652.3±65.0 °C(Predicted)
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密度:
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1.30±0.1 g/cm3(Predicted)
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储存条件:
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Sealed in dry,Store in freezer, under -20°C
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溶解度:
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≥20 mg/mL in DMSO; insoluble in H2O; ≥51.1 mg/mL in EtOH with gentle warming
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形态:
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White solid
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酸度系数(pKa):
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13.95±0.10(Predicted)
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InChIKey:
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NQVIIUBWMBHLOZ-UHFFFAOYSA-N
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CVT 313性质、用途与生产工艺
CVT-313是有效的CDK2抑制剂，在体外的IC50值为0.5 μM。它对其他非相关的、依赖于ATP的丝氨酸/苏氨酸激酶没有作用。
| Target | Value |
CDK2
(Cell-free assay)
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0.5 μM
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CVT-313 (Cdk2 Inhibitor III) has been shown to inhibit other kinases, but at much higher IC
50
values, i.e., CDK1 (IC
50
=4.2 μM), CDK4 D1 (IC
50
=215 μM), and MAPK/PKA/PKC (IC
50
>1.25 mM), compared to CDK2 (IC
50
=0.5 μM). CVT-313 has been shown to have profound effects on cell proliferation at concentrations of 5-20 μM. CVT-313 is a potent CDK2 inhibitor, which is identified from a purine analog library with an IC
50
of 0.5 μM in vitro. Inhibition is competitive with respect to ATP (K
i
=95 nM), and selective CVT-313 has no effect on other, nonrelated ATP-dependent serine/threonine kinases. When added to CDK1 or CDK4, a 8.5- and 430-fold higher concentration of CVT-313 is required for half-maximal inhibition of the enzyme activity. Using normal and tumor human/murine cell lines, the effects of CVT-313 on cell proliferation is measured. The IC
50
for growth inhibition ranged from 1.25 to 20 μM.
CVT 313
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-15339 | CVT 313
CVT-313 | 199986-75-9 | 5mg | 818元 |
| 2024/04/30 | HY-15339 | CVT 313
CVT-313 | 199986-75-9 | 10mM * 1mLin DMSO | 900元 |
199986-75-9, CVT 313 相关搜索:
- 合成有机化合物配体
- 细胞生物学试剂
- C20H28N6O3
- 2,2'-((9-异丙基-6-((4-甲氧基苄基)氨基)-9H-嘌呤-2-基)氮烷二基)二乙醇
- CVT-313,CDK2抑制剂
- 2,2'-((9-异丙基-6-((4-甲氧基苄基)氨基)-9H-嘌呤-2-基)氮烷二基)二乙醇
- 化合物CVT313
- CVT-313游离态
- CDK2抑制剂(CVT-313)
- 199986-75-9
- 2,2'-((9-isopropyl-6-((4-methoxybenzyl)amino)-9H-purin-2-yl)azanediyl)diethanol
- inhibit,CDK,Cyclin dependent kinase,CVT-313,Inhibitor
- Cdk2 Inhibitor III - CAS 199986-75-9 - Calbiochem
- CVT 313;NG 26;CVT313;NG26
- CVT-313, >98%
- CS-2441
- CVT 313;NG 26;CVT313;NG26;NG-26
- CVT-313 (CDK2 INHIBITOR III)
- Ethanol,2,2'-[[6-[[(4-methoxyphenyl)methyl]amino]-9-(1-methylethyl)-9H-purin-2-yl]imino]bis-
- 2,2'-[[6-[[(4-Methoxyphenyl)methyl]amino]-9-(1-methylethyl)-9H-purin-2-yl]imino]bisethanol
- NG 26
- CVT-313(NG-26)
- 2,2'-(9-isopropyl-6-(4-methoxybenzylamino)-9H-purin-2-ylazanediyl)diethanol
- D6S82E
- BAT5
- Anti-ABHD16A antibody produced in rabbit
- 2(BIS-(HYDROXYETHYL)AMINO)-6-(4-METHOXYBENZYLAMINO)-9-ISOPROPYL-PURINE
- CDK2 INHIBITOR III
- CVT-313