(E)-位变异烟碱
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- CAS号:
- 15585-43-0
- 英文名:
- rivanicline
- 英文别名:
- rivanicline;Unii-6H35lf645a;(E)-Metanicotine;trans-Metanicotine;RIVANICLINE;METANICOTINE;RJR 2403;(E)-N-methyl-4-(3-pyridinyl)-3-butene-1-amine;(3E)-N-Methyl-4-(3-pyridinyl)-3-buten-1-amine;(E)-N-methyl-4-(pyridin-3-yl)but-3-en-1-amine;3-Buten-1-amine, N-methyl-4-(3-pyridinyl)-, (3E)-;But-3-en-1-amine, N-methyl-4-(pyridin-3-yl)-, (E)-
- 中文名:
- (E)-位变异烟碱
- 中文别名:
- (E)-位变异烟碱;化合物 T12738L
- CBNumber:
- CB51508612
- 分子式:
- C10H14N2
- 分子量:
- 162.23156
- MOL File:
- 15585-43-0.mol
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(E)-位变异烟碱化学性质
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沸点:
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99-101°C/0.4mm Hg
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密度:
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0.980
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闪点:
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130℃
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储存条件:
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2-8°C(protect from light)
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溶解度:
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Soluble in DMSO
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形态:
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Powder
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酸度系数(pKa):
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10.03±0.10(Predicted)
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稳定性:
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Hygroscopic
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(E)-位变异烟碱性质、用途与生产工艺
Rivanicline (RJR-2403; (E)-Metanicotine) 是神经元烟碱受体(neuronal nicotinic receptor) 的抑制剂,对 α4β2 亚型有高度选择性,Ki 为 26 nM,比对 α7 受体的抑制性高超过1000倍。
用途
An alkaloid found in the leaves of Duboisia Hopwoodii, and a constitutent of tobacco smoke. Also used a potential drug for the treatment of senile dementia of the Alzheimer鈥檚 type and currently being
investigated as a nicotinic agonist with CNS selectivity. Metanicotine may have clinical potential due to its high selectivity for CNS nicotinic acetylcholine receptor subtypes relative to periphera
l ganglionic and muscle-type nicotinic acetylcholine receptors.
(E)-位变异烟碱
上下游产品信息
上游原料
下游产品
15585-43-0, (E)-位变异烟碱 相关搜索:
- Nicotine Derivatives
- 神经信号
- 化合物 T12738L
- (E)-位变异烟碱
- 15585-43-0
- (E)-N-methyl-4-(pyridin-3-yl)but-3-en-1-amine
- 3-Buten-1-amine, N-methyl-4-(3-pyridinyl)-, (3E)-
- (E)-N-methyl-4-(3-pyridinyl)-3-butene-1-amine
- RIVANICLINE;METANICOTINE;RJR 2403
- trans-Metanicotine
- (3E)-N-Methyl-4-(3-pyridinyl)-3-buten-1-amine
- (E)-N-[Methyl]-4-(3-pyridinyl)-3-buten-1-aMine, RJR 2403
- (E)-Metanicotine
- Unii-6H35lf645a
- But-3-en-1-amine, N-methyl-4-(pyridin-3-yl)-, (E)-
- rivanicline