CS-2692
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- CAS号:
- 87134-87-0
- 英文名:
- R(+)-7-CHLORO-8-HYDROXY-3-METHYL-1-PHENYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE HYDROCHLORIDE
- 英文别名:
- CS-2692;SCH 23390;SCH23390HCl;SCH-23390 maleate;R-(+)-SCH-23390 maleate;R(+)-SCH-23390 HYDROCHLORIDE;(R)-8-chloro-3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ol;R-(+)-7-CHLORO-8-HYDROXY-3-METHYL-1-PHENYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE HCL;8-Chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepin-7-ol, hydrochloride, (R);1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl-, hydrochloride, (5R)-
- 中文名:
- CS-2692
- 中文别名:
- 化合物 T12865;化合物SCH-23390 MALEATE
- CBNumber:
- CB5335703
- 分子式:
- C17H19Cl2NO
- 分子量:
- 324.24
- MOL File:
- 87134-87-0.mol
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CS-2692化学性质
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溶解度:
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H2O: ≥5 mg/mL
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形态:
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solid
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颜色:
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white
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CS-2692性质、用途与生产工艺
SCH-23390 maleate (R-(+)-SCH-23390 maleate) 是一种有效的选择性的多巴胺 D1 样受体拮抗剂,其对 D1 和 D5 受体的 Ki 分别为 0.2 nM 和 0.3 nM。SCH-23390 maleate 也是一种有效的人 5-HT2C 受体激动剂,Ki 为 9.3 nM。SCH-23390 maleate 与 5-HT2 和 5-HT1C 受体具有高亲和力。SCH-23390 maleate 还抑制 G 蛋白偶联的内向整流钾 (GIRK) 通道,IC50 为 268 nM。
D
1
Receptor
0.2 nM (Ki)
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D
5
Receptor
0.3 nM (Ki)
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5-HT
2C
Receptor
9.3 nM (Ki)
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GIRK
268 nM (IC
50
)
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SCH-23390 (1 μM) treatment reverses the inhibitory effects of Isosibiricin on NLRP3 expression and the cleavages of caspase-1 and IL-1β in the LPS-induced BV-2 cells. SCH-23390 could reverse the Isosibiricin-mediated inhibition of the NLRP3/caspase-1 inflammasome pathway.
SCH-23390 can abolish generalized seizures evoked by the chemoconvulsants: pilocarpine and soman. SCH-23390 has also been used in studies of other neurological disorders in which the dopamine system has been implicated, such as psychosis and Parkinson's disease. Apart from the study of neurological disorders, SCH-23390 has been extensively used as a tool in the topographical determination of brain D
1
receptors in rodents, nonhuman primates, and humans.
SCH-23390 is a very short-acting compound with an elimination half-life of around 25 min following administration of 0.3 mg/kg i.p. in the rat.
SCH-23390 augments dopamine-induced ductus constriction in CD-1 mouse vessels under newborn O
2
conditions.
CS-2692
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2021/03/30 | S2834 | CS-2692 SCH-23390 maleate | 87134-87-0 | 25mg | 7199.01元 |
87134-87-0, CS-2692 相关搜索:
- Dopamine receptor
- C17H19Cl2NO
- C17H18ClNOHCl
- 化合物SCH-23390 MALEATE
- 化合物 T12865
- 87134-87-0
- 5-HT Receptor,constriction,Dopamine Receptor,5‐HT1C,SCH 23390,Potassium Channel,DA1-like,GIRK,SCH 23390 maleate,ductus,SCH-23390,D5-receptor,inhibit,SCH23390,neurological,SCH23390 maleate,Inhibitor,5-hydroxytryptamine Receptor,KcsA,enantioselective,5‐HT2,Serotonin Receptor,epileptiform
- SCH-23390 maleate
- R-(+)-SCH-23390 maleate
- CS-2692
- (R)-8-chloro-3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ol
- SCH23390HCl
- SCH 23390
- R(+)-SCH-23390 HYDROCHLORIDE
- R-(+)-7-CHLORO-8-HYDROXY-3-METHYL-1-PHENYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE HCL
- 8-Chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepin-7-ol, hydrochloride, (R)
- 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl-, hydrochloride, (5R)-