内皮素2
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- CAS号:
- 123562-20-9
- 英文名:
- H-CYS-SER-CYS-SER-SER-TRP-LEU-ASP-LYS-GLU-CYS-VAL-TYR-PHE-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH
- 英文别名:
- ET-2 (HUMAN);ENDOTHELIN 2;ENDOTHELIN 2 HUMAN;Human endothelin-2;ENDOTHELIN-II, HUMAN;Endothelin-2 (49-69);ET-2 (HUMAN, PIG, DOG);Endothelin 2 (huMan)(9CI);EDOTHELIN 2 HUMAN 50 UG;Endothelin-2 (49-69), human
- 中文名:
- 内皮素2
- 中文别名:
- 内皮素2;人内皮素-2;内皮素2, ≥97.0% (HPLC)
- CBNumber:
- CB5442638
- 分子式:
- C115H160N26O32S4
- 分子量:
- 2546.92
- MOL File:
- 123562-20-9.mol
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内皮素2化学性质
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储存条件:
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−20°C
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溶解度:
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Soluble to 1 mg/ml in DMSO
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形态:
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powder
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颜色:
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white
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水溶解性:
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Soluble in water (1 mg/ml)
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内皮素2性质、用途与生产工艺
内皮素具有内皮素1、内皮素2、内皮素3、和β-内皮素4种异形肽。体内分布十分广泛，在循环系统中静脉含量高于动脉，冠状动脉明显高于肺动脉；心房含量高于心室、心内膜高于心外膜；神经、消化、生殖等系统的组织中亦存在内皮素。内皮素的消除降解主要在肺、肾和血管平滑肌细胞，半衰期在1小时以上。
内皮素2被认为是如同CC趋化因子配体2(C-Cmotifchemokineligand2，CCL2)一样，是有效的炎症趋化因子，对中性粒细胞有低水平趋化作用，能够通过MAPK通路，由内皮素B受体介导在巨噬细胞的趋化作用。
Endothelin-2 (49-69), human (Endothelin-2 (human, canine)) 是由 21 个氨基酸组成的血管活性肽，可与 G 蛋白连接的跨膜受体，ET-RA 和 ET-RB 结合。
At nanomolar concentrations, Endothelin-2 exhibits a strong and long-lasting vasoconstrictor activity characteristic of endothelin (EC
50
=0.52 nM).
Endothelin-2 is a chemoattractant for macrophages and THP-1 monocytic cells, but not for freshly isolated monocytes. The chemotactic response to Endothelin-2 shows a typical bell-shaped response curve. Experiments with endothelin receptor antagonists shows that migration to Endothelin-2 is mediated via the ET-RB receptor. Endothelin-2 expression by tumors may modulate the behavior of macrophages such that activated cells accumulate in areas of hypoxia.
Two distinct phases of pressor effects are typically seen in response to Endothelin-2: the early phase immediately follows the depressor response and dominates during the next 3-10 min, whereas the late pressor effect develops 10-20 min after the injection and lasts >1 hr.
内皮素2
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2023/03/20 | HY-P0207 | 内皮素2
Endothelin-2 (49-69), human | 123562-20-9 | 500μg | 3120元 |
| 2023/03/20 | HY-P0207 | 内皮素2
Endothelin-2 (49-69), human | 123562-20-9 | 1mg | 5040元 |
内皮素2
生产厂家
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内皮素2国内生产厂家
123562-20-9, 内皮素2 相关搜索:
- Endothelin receptor
- Peptides for Cell Biology
- Endothelins
- Cell Signaling Enzymes
- Chymase and Related Products
- AgonistsApplication Index
- Peptide
- Cardiovescular
- 多肽
- 目录肽
- 细胞信号和神经生物学
- 细胞生物学
- Agonist
- BioChemical
- Biochemicals and Reagents
- Amino Acids and Peptides
- Peptides
- Endothelins
- C115H160N26O32S4
- 内皮素2, ≥97.0% (HPLC)
- 人内皮素-2
- 内皮素2
- 123562-20-9
- peptide,21-amino,inhibit,Human endothelin 2,vasoactive,acid,ET-RB,Endothelin 2 (49 69), human,Endothelin2 (4969), human,Human endothelin2,ET-RA,Inhibitor,transmembrane
- Endothelin-2 (49-69)
- Endothelin-2 (49-69), human
- H-CYS-SER-CYS-SER-SER-TRP-LEU-ASP-LYS-GLU-CYS-VAL-TYR-PHE-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH USP/EP/BP
- Endothelin 1 (swine), 6-L-tryptophan-7-L-leucine-
- Endothelin 2, human, ≥97.0% (HPLC)
- EDOTHELIN 2 HUMAN 50 UG
- Endothelin 2 (huMan)(9CI)
- Human endothelin-2
- Endothelin 2 (Canis familiaris)
- Endothelin 2, huManEndotheli
- M.W. 2546.92 C115H160N26O32S4
- ET-2 (huMan, canine), VIC (huMan, canine)
- Cys-Ser-Cys-Ser-Ser-Trp-Leu-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp (Disulfide bridges Cys1-Cys15 and Cys3-Cys11)
- Endothelin-2 (huMan, canine)
ET-2 (huMan, canine), VIC (huMan, canine)
- CYS-SER-CYS-SER-SER-TRP-LEU-ASP-LYS-GLU-CYS-VAL-TYR-PHE-CYS-HIS-LEU-ASP-ILE-ILE-TRP: CSCSSWLDKECVYFCHLDIIW DISULFIDE BRIDGES CYS1-CYS15, CYS3-CYS11
- CYS-SER-CYS-SER-SER-TRP-LEU-ASP-LYS-GLU-CYS-VAL-TYR- PHE-CYS-HIS-LEU-ASP-ILE-ILE-TRP(DISULFIDE BRIDGE:CYS1-CYS15, CYS3-CYS11)
- CSCSSWLDKECVYFCHLDIIW (DISULFIDE BRIDGE: 1-15 AND 3-11)
- CYS-SER-CYS-SER-SER-TRP-LEU-ASP-LYS-GLU-CYS-VAL-TYR-PHE-CYS-HIS-LEU-ASP-ILE-ILE-TRP HUMAN
- CYS-SER-CYS-SER-SER-TRP-LEU-ASP-LYS-GLU-CYS-VAL-TYR-PHE-CYS-HIS-LEU-ASP-ILE-ILE-TRP
- ENDOTHELIN-2 (HUMAN, PIG, DOG)
- ENDOTHELIN-2 (HUMAN, CANINE)
- ENDOTHELIN 2 HUMAN
- ENDOTHELIN 2
- ENDOTHELIN-II, HUMAN
- H-CYS-SER-CYS-SER-SER-TRP-LEU-ASP-LYS-GLU-CYS-VAL-TYR-PHE-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH (DISULFIDE BRIDGE: 1-15 AND 3-11)
- H-CYS-SER-CYS-SER-SER-TRP-LEU-ASP-LYS-GLU-CYS-VAL-TYR-PHE-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH
- ET-2 (HUMAN, PIG, DOG)
- ET-2 (HUMAN)