3-[[5-(2,3-二氯苯基)-1H-四唑-1-基]甲基]吡啶
|
|
|
- CAS号:
- 899507-36-9
- 英文名:
- 3-[[5-(2,3-DICHLOROPHENYL)-1H-TETRAZOL-1-YL]METHYL]PYRIDINE HYDROCHLORIDE
- 英文别名:
- A 438079;A 438079 HCI;A 438079 hydrochlori;A 438079 HYDROCHLORIDE;3-[[5-(2,3-Dichlorophenyl)-1H-tetrazol-1-yl]methyl]pyridine;Inhibitor,P2X Receptor,A438079,inhibit,A 438079,P2XRs,A-438079;Pyridine, 3-[[5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl]methyl]-;3-{[5-(2,3-DICHLOROPHENYL)-1H-1,2,3,4-TETRAZOL-1-YL]METHYL}PYRIDINE;3-[[5-(2,3-DICHLOROPHENYL)-1H-TETRAZOL-1-YL]METHYL]PYRIDINE HYDROCHLORIDE;3-[[5-(2,3-Dichlorophenyl)-1H-tetrazol-1-yl]methyl]pyridine CAS NO.899507-36-9
- 中文名:
- 3-[[5-(2,3-二氯苯基)-1H-四唑-1-基]甲基]吡啶
- 中文别名:
- 化合物A 438079;3-[[5-(2,3-二氯苯基)-1H-四唑-1-基]甲基]吡啶
- CBNumber:
- CB62453448
- 分子式:
- C13H9Cl2N5
- 分子量:
- 306.15
- MOL File:
- 899507-36-9.mol
|
|
|
3-[[5-(2,3-二氯苯基)-1H-四唑-1-基]甲基]吡啶化学性质
-
储存条件:
-
Desiccate at RT
-
|
-
溶解度:
-
Soluble in DMSO
-
|
-
形态:
-
Powder
-
|
3-[[5-(2,3-二氯苯基)-1H-四唑-1-基]甲基]吡啶性质、用途与生产工艺
A 438079 是一种有效的，选择性的 P2X7 受体拮抗剂，pIC50 值为 6.9。
pIC50: 6.9 (P2X
7
receptor)
In 1321N1 cells stably expressing rat P2X
7
receptors, A 438079 blocks BzATP-(10 μM) evoked changes in intracellular calcium concentrations with an IC
50
of 321 nM. A 438079 is also selective for the P2X
7
receptor, at concentrations up to 100 μM.
A 438079 (80 μmol/kg, i.v.) reduces noxious and innocuous evoked activity of different classes of spinal neurons in neuropathic rats. A 438079 (100 and 300 μmol/kg, i.p.) significantly raises withdrawal thresh-olds in both the SNL and CCI models. Intraperitoneal injection of A 438079 (5 and 15 mg/kg) 60 min after triggering seizures reduces seizure severity and neuronal death within the hippocampus. A 438079 has superior neuroprotective effects compared with an equally dose of phenobarbital (25 mg/kg). A 438079 partially but significantly prevents the 6-OHDA-induced depletion of striatal DA stores. Pretreatment with A 438079 reduces nociceptive behaviour scores in the HC model.
3-[[5-(2,3-二氯苯基)-1H-四唑-1-基]甲基]吡啶
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-15488A | A 438079 hydrochloride | | 1 mg | 316元 |
| 2024/04/30 | HY-15488A | A 438079 hydrochloride | | 5 mg | 697元 |
3-[[5-(2,3-二氯苯基)-1H-四唑-1-基]甲基]吡啶
生产厂家
899507-36-9, 3-[[5-(2,3-二氯苯基)-1H-四唑-1-基]甲基]吡啶 相关搜索:
- C13H9Cl2N5HCl
- C13H10Cl3N5
- C13H9Cl2N5
- 化合物A 438079
- 3-[[5-(2,3-二氯苯基)-1H-四唑-1-基]甲基]吡啶
- 899507-36-9
- Inhibitor,P2X Receptor,A438079,inhibit,A 438079,P2XRs,A-438079
- 3-[[5-(2,3-Dichlorophenyl)-1H-tetrazol-1-yl]methyl]pyridine CAS NO.899507-36-9
- A 438079 HCI
- Pyridine, 3-[[5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl]methyl]-
- 3-{[5-(2,3-DICHLOROPHENYL)-1H-1,2,3,4-TETRAZOL-1-YL]METHYL}PYRIDINE
- A 438079 hydrochlori
- 3-[[5-(2,3-Dichlorophenyl)-1H-tetrazol-1-yl]methyl]pyridine
- A 438079
- A 438079 HYDROCHLORIDE
- 3-[[5-(2,3-DICHLOROPHENYL)-1H-TETRAZOL-1-YL]METHYL]PYRIDINE HYDROCHLORIDE