RWJ 50271
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- CAS号:
- 162112-37-0
- 英文名:
- RWJ 50271
- 英文别名:
- RWJ 50271;N-(3-Hydroxypropyl)-5-methyl-1-(4-(3-(trifluoromethyl)phenyl)thiazol-2-yl)-1H-pyrazole-4-carboxamide;N-(3-hydroxypropyl)-5-methyl-1-[4-[3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]pyrazole-4-carboxamide;1H-Pyrazole-4-carboxamide, N-(3-hydroxypropyl)-5-methyl-1-[4-[3-(trifluoromethyl)phenyl]-2-thiazolyl]-;N-(3-Hydroxypropyl)-5-methyl-1-[-4-[3-(trifluoromethyl)phenyl)]-2-thiazolyl]-1H-pyrazole-4-carboxamide;inhibit,RWJ 50271,arthritis,RWJ-50271,organ,Inhibitor,transplantation,cell,Integrin,RWJ50271,rheumatoid,adhesion,molecules
- 中文名:
- RWJ 50271
- 中文别名:
- 化合物RWJ 50271;RWJ 50271,LFA-1 / ICAM介导的细胞粘附抑制剂;N-(3-羟丙基)-5-甲基-1-(4-(3-(三氟甲基)苯基)噻唑-2-基)-1H-吡唑-4-甲酰胺
- CBNumber:
- CB62538284
- 分子式:
- C18H17F3N4O2S
- 分子量:
- 410.41
- MOL File:
- 162112-37-0.mol
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RWJ 50271化学性质
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密度:
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1.44±0.1 g/cm3(Predicted)
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储存条件:
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Store at RT
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溶解度:
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<41.04mg/ml in DMSO
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酸度系数(pKa):
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14.28±0.46(Predicted)
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RWJ 50271性质、用途与生产工艺
RWJ 50271 是一种选择性的，具有口服活性的 LFA-1/ICAM-1 相互作用抑制剂，IC50 值为 5.0 μM (HL60 cells)。RWJ 50271 抑制 LFA-1/ICAM-1 介导的细胞粘附。
IC50: 5.0 μM (LFA-1/ICAM-1, HL60 cells)
RWJ 50271 inhibits adhesion of peripheral blood lymphocytes to plastic immobilized SICAM-1.
RWJ 50271 inhibits both human and murine NK activity (IC
50
=5.0 μM) in an LFA-1/ICAM-1-dependent natural killer [NK] cytotoxicity assay.
RWJ 50271 does not inhibit Mac-1/ICAM-1, E-selectidsialyl Lewis X or VLA-4/VCAM-1-mediated cell adhesion up to 20 μM concentrations.
RWJ 50271 does not alter the LFA-1 expression levels on HL60 cells.
RWJ 50271 inhibits adhesion of peripheral blood lymphocytes to plastic immobilized SICAM-1.
RWJ 50271 does not exhibit any toxic activity up to 100 μM concentrations.
RWJ 50271 (50 mg/kg; p.o.) is effective in animal model of inflammation.
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Animal Model:
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Mice, the delayed-type hypersensitivity [DTH] reaction model
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Dosage:
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50 mg/kg
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Administration:
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Oral administration
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Result:
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Significantly reduced foot pad swelling (>50%) 48 h after the challenge.
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RWJ 50271
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-110086 | RWJ 50271 | | 1 mg | 900元 |
| 2024/04/30 | HY-110086 | RWJ 50271
RWJ 50271 | 162112-37-0 | 5mg | 1800元 |
162112-37-0, RWJ 50271 相关搜索:
- 酶
- 对照品
- C18H17F3N4O2S
- RWJ 50271,LFA-1 / ICAM介导的细胞粘附抑制剂
- N-(3-羟丙基)-5-甲基-1-(4-(3-(三氟甲基)苯基)噻唑-2-基)-1H-吡唑-4-甲酰胺
- 化合物RWJ 50271
- 162112-37-0
- inhibit,RWJ 50271,arthritis,RWJ-50271,organ,Inhibitor,transplantation,cell,Integrin,RWJ50271,rheumatoid,adhesion,molecules
- N-(3-Hydroxypropyl)-5-methyl-1-(4-(3-(trifluoromethyl)phenyl)thiazol-2-yl)-1H-pyrazole-4-carboxamide
- 1H-Pyrazole-4-carboxamide, N-(3-hydroxypropyl)-5-methyl-1-[4-[3-(trifluoromethyl)phenyl]-2-thiazolyl]-
- N-(3-Hydroxypropyl)-5-methyl-1-[-4-[3-(trifluoromethyl)phenyl)]-2-thiazolyl]-1H-pyrazole-4-carboxamide
- N-(3-hydroxypropyl)-5-methyl-1-[4-[3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]pyrazole-4-carboxamide
- RWJ 50271