BIQ
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- CAS号:
- 223387-75-5
- 英文名:
- FG 2216
- 英文别名:
- BIQ;IOX-3;YM 311;FG2216;FG-2216;FG 2216;CS-1687;FG-2216(IOX3;FG-2216 - YM 311;FG2216;FG-2216;FG 2216
- 中文名:
- BIQ
- 中文别名:
- FG-2216 游离;化合物FG-2216;2-(1-氯-4-羟基异喹啉-3-甲酰胺)乙酸;2-(1-氯-4-羟基异喹啉-3-甲酰氨基)乙酸;[[(1-氯-4-羟基异喹啉-3-基)羰基]氨基]乙酸
- CBNumber:
- CB62666905
- 分子式:
- C12H9ClN2O4
- 分子量:
- 280.66
- MOL File:
- 223387-75-5.mol
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BIQ化学性质
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沸点:
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670.6±55.0 °C(Predicted)
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密度:
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1.571±0.06 g/cm3(Predicted)
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储存条件:
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-20°C
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溶解度:
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insoluble in H2O; ≥14.05 mg/mL in DMSO; ≥5.12 mg/mL in EtOH with ultrasonic
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形态:
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powder
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酸度系数(pKa):
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3.20±0.10(Predicted)
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颜色:
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white to beige
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BIQ性质、用途与生产工艺
FG-2216是一种有效的，口服具有活性的 HIF 脯氨酰4-羟化酶抑制剂，对PHD2的 IC50 为 3.9 μM。Phase 2。
| Target | Value |
PHD2
(Cell-free assay)
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3.9 μM
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在雄性恒河猴中，FG-2216 (60 mg/kg, p.o.)诱导显著且可逆的Epo诱导，并诱导HbF表达小幅增高。
FG-2216 (40-60 mg/kg; p.o. twice a week for 150 d) induces erythropoiesis and a small elevation of hemoglobin (HbF) expression, and is well tolerated in rhesus macaques.
FG-2216 (50 mg/kg; p.o. once daily for 4 or 12 d) increases hematocrit, red blood cell counts, and hemoglobin levels in mice.
FG-2216 (40-60 mg/kg; a single p.o) reversibly induces endogenous Epo in rhesus macaques.
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Animal Model:
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Male rhesus macaques (3-6 years; 4-7 kg) mice are treated with large-volume phlebotomy with iron supplementation
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Dosage:
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40, 60 mg/kg
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Administration:
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P.o. (40 mg/kg) twice a week for 6-8 weeks
P.o. (60 mg/kg) twice a week for 6-8 weeks
P.o. (60 mg/kg) twice a week for 6-8 weeks
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Result:
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Exhibited reticulocytosis within 1-2 weeks of dosing.
Increased total hemoglobin levels at the end of the study duration.
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BIQ
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-15641 | BIQ
FG-2216 | 223387-75-5 | 2mg | 900元 |
| 2024/04/30 | HY-15641 | BIQ
FG-2216 | 223387-75-5 | 5 mg | 1300元 |
BIQ
生产厂家
全球有 84家供应商
BIQ国内生产厂家
223387-75-5, BIQ 相关搜索:
- Inhibitors
- 药靶配体
- 小分子抑制剂
- 小分子抑制剂，天然产物
- FG-2216 游离
- 化合物FG-2216
- 2-(1-氯-4-羟基异喹啉-3-甲酰胺)乙酸
- 2-(1-氯-4-羟基异喹啉-3-甲酰氨基)乙酸
- [[(1-氯-4-羟基异喹啉-3-基)羰基]氨基]乙酸
- 223387-75-5
- IOX-3
- (1-Chloro-4-hydroxyisoquinoline-3-carbonyl)glycine
- 2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido)acetic acid
- BIQ
- FG-2216 - YM 311
- FG-2216(IOX3
- CS-1687
- Glycine, N-[(1-chloro-4-hydroxy-3-isoquinolinyl)carbonyl]-
- FG2216;FG-2216;FG 2216
- (N-(1-chloro-4-hydroxy-isoquinoline-3-carbonyl)-amino)-acetic acid
- N-[(1-Chloro-4-hydroxy-3-isoquinolinyl)carbonyl]glycine
- (Z)-2-(((1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)(HYDROXY)METHYLENE)AMINO)ACETIC ACID
- YM 311
- FG 2216 (erythropoietic agent)
- [[(1-Chloro-4-hydroxyisoquinolin-3-yl)carbonyl]amino]acetic acid
- FG-2216
- FG2216
- FG 2216