TAI-1
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- CAS号:
- 1334921-03-7
- 英文名:
- TAI-1
- 英文别名:
- TAI 1;TAI1;TAI-1 USP/EP/BP;TAI 1,TAI1,inhibit,Inhibitor,Apoptosis,TAI-1;N-(4-(4-(4-methoxyphenoxy)-2,6-dimethylphenyl)thiazol-2-yl)isonicotinamide;4-Pyridinecarboxamide, N-[4-[4-(4-methoxyphenoxy)-2,6-dimethylphenyl]-2-thiazolyl]-
- 中文名:
- TAI-1
- 中文别名:
- 化合物TAI1
- CBNumber:
- CB62744616
- 分子式:
- C24H21N3O3S
- 分子量:
- 431.51
- MOL File:
- 1334921-03-7.mol
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TAI-1化学性质
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密度:
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1.281±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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≥43.2 mg/mL in DMSO; insoluble in H2O; ≥3.17 mg/mL in EtOH
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形态:
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solid
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酸度系数(pKa):
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5.38±0.70(Predicted)
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TAI-1性质、用途与生产工艺
TAI-1是一个有效的特异Hec1抑制剂，会打乱Hec1-Nek2蛋白质相互作用。
TAI-1 disrupts the binding of Nek2 to Hec1, which leads to degradation of Nek2 and chromosomal misalignment. TAI-1 shows strong growth inhibitory potency at nM levels across a broad spectrum of tumor cells, and produces synergistic activity with doxorubicin, topotecan and paclitaxel in leukemia, breast and liver cancer cells.
TAI-1 (20 mg/kg i.v. or 150 mg/kg p.o.) causes significant tumor growth delay in Huh-7 model and modest tumor inhibition in Colo205 and MDA-MB-231 models.
TAI-1
上下游产品信息
上游原料
下游产品
1334921-03-7, TAI-1 相关搜索:
- Inhibitors
- 药靶配体
- 小分子抑制剂，天然产物
- 化合物TAI1
- 1334921-03-7
- TAI 1,TAI1,inhibit,Inhibitor,Apoptosis,TAI-1
- TAI-1 USP/EP/BP
- 4-Pyridinecarboxamide, N-[4-[4-(4-methoxyphenoxy)-2,6-dimethylphenyl]-2-thiazolyl]-
- TAI 1;TAI1
- N-(4-(4-(4-methoxyphenoxy)-2,6-dimethylphenyl)thiazol-2-yl)isonicotinamide