CPD1578
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- CAS号:
- 125079-83-6
- 英文名:
- CU-CPT-8m
- 英文别名:
- CPD1578;CU-CPT-8m;cas 125079-83-6;TLR8-specific antagonist;CU-CPT-8M;CAS 125079-83-6 ;TLR8 INHIBITOR;7-(m-tolyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;CU CPT 8m,inhibit,Toll-like Receptor (TLR),CUCPT8m,Inhibitor;Pyrazolo[1,5-a]pyrimidine-3-carboxamide, 7-(3-methylphenyl)-
- 中文名:
- CPD1578
- 中文别名:
- 化合物CU-CPT-8M;7-(间甲苯基)吡唑并[1,5-A]嘧啶-3-甲酰胺
- CBNumber:
- CB63369601
- 分子式:
- C14H12N4O
- 分子量:
- 252.27
- MOL File:
- 125079-83-6.mol
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CPD1578化学性质
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密度:
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1.35±0.1 g/cm3(Predicted)
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储存条件:
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Sealed in dry,Room Temperature
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溶解度:
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Chloroform: 5 mg/ml; DMF: 0.2 mg/ml; DMSO: 0.2 mg/ml; Ethanol: slightly soluble
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形态:
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A crystalline solid
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酸度系数(pKa):
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12.41±0.50(Predicted)
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InChI:
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InChI=1S/C14H12N4O/c1-9-3-2-4-10(7-9)12-5-6-16-14-11(13(15)19)8-17-18(12)14/h2-8H,1H3,(H2,15,19)
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InChIKey:
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HNKGGVGQAVODNJ-UHFFFAOYSA-N
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SMILES:
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C12=C(C(N)=O)C=NN1C(C1=CC=CC(C)=C1)=CC=N2
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CPD1578性质、用途与生产工艺
CU-CPT-8m 是 TLR8 的特异性拮抗剂，其 IC50 值为 67 nM。
CU-CPT-8m is a specific
TLR8
antagonist, with an
IC
50
of 67±10 nM and negligible cytotoxicity. The K
d
value of CU-CPT-8m is determined to be 220 nM. CU-CPT-8m only reduces the proinflammatory response in the TLR8-overexpressing cells strongly supports that CU-CPT-8m directly recognizes TLR8 in cells. It is particularly notable that TLR7 signaling is not affected at concentrations up to 75 μM. TLR7 and TLR8 are closely related and share many common ligands. Treatment of 1 μM CU-CPT-8m completely abolishes the elevation of TNF-α and IL-8 mRNA levels induced by R848. CU-CPT-8m inhibits R848-induced TNF-α production in the differentiated THP-1 monocytes cells in a dose-dependent manner with an IC
50
of 90±10 nM, which is in good agreement with its IC
50
value determined in HEK-Blue TLR8 cells.
CPD1578
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-112050 | CU-CPT-8m | | 1 mg | 502元 |
| 2024/04/30 | HY-112050 | CPD1578
CU-CPT-8m | 125079-83-6 | 10mM * 1mLin DMSO | 1393元 |
125079-83-6, CPD1578 相关搜索:
- 合成有机化合物配体
- 化工试剂
- 化合物CU-CPT-8M
- 7-(间甲苯基)吡唑并[1,5-A]嘧啶-3-甲酰胺
- 125079-83-6
- CU CPT 8m,inhibit,Toll-like Receptor (TLR),CUCPT8m,Inhibitor
- Pyrazolo[1,5-a]pyrimidine-3-carboxamide, 7-(3-methylphenyl)-
- 7-(m-tolyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide
- TLR8-specific antagonist
- CU-CPT-8M;CAS 125079-83-6 ;TLR8 INHIBITOR
- cas 125079-83-6
- CU-CPT-8m
- CPD1578